FK506 alleviates proteinuria in rats with adriamycin-induced nephropathy by down-regulating TRPC6 and CaN expression

To investigate the roles of transient receptor potential cation channel 6 (TRPC6) and calcineurin (CaN) in proteinuria pathogenesis and the mechanism of action of the calcineurin inhibitor tacrolimus (FK506) in adriamycin-induced nephropathy. The adriamycin-induced nephropathy rats were established...

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Veröffentlicht in:	Journal of nephrology 2012-11, Vol.25 (6), p.918-925
Hauptverfasser:	Liu, Yaqing, Ji, Zequan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomarkers - blood Biomarkers - urine Blotting, Western Calcineurin - genetics Calcineurin - metabolism Calcineurin Inhibitors Cytoprotection Disease Models, Animal Dose-Response Relationship, Drug Down-Regulation Doxorubicin Enzyme Inhibitors - pharmacology Immunohistochemistry Kidney - drug effects Kidney - metabolism Kidney - pathology Kidney Diseases - chemically induced Kidney Diseases - drug therapy Kidney Diseases - genetics Kidney Diseases - metabolism Kidney Diseases - pathology Male Proteinuria - chemically induced Proteinuria - genetics Proteinuria - metabolism Proteinuria - prevention & control Rats Rats, Sprague-Dawley Real-Time Polymerase Chain Reaction Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - metabolism Tacrolimus - pharmacology Time Factors TRPC Cation Channels - drug effects TRPC Cation Channels - genetics TRPC Cation Channels - metabolism
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