Renal Choriocarcinoma: Gestational or Germ Cell Origin?
Choriocarcinoma is a rare, highly malignant trophoblastic tumor with gestational or, rarely, germ cell origin. Primary extragenital localization is extremely rare. This report describes a choriocarcinoma case clinically mimicking a primary renal cell carcinoma with multiplex pulmonary metastases. Di...
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| Veröffentlicht in: | International journal of surgical pathology 2012-12, Vol.20 (6), p.623-628 |
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| container_title | International journal of surgical pathology |
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| creator | Vereczkey, Ildikó Csernák, Erzsébet Olasz, Judit Küronya, Zsófia Szentirmay, Zoltán Tóth, Erika |
| description | Choriocarcinoma is a rare, highly malignant trophoblastic tumor with gestational or, rarely, germ cell origin. Primary extragenital localization is extremely rare. This report describes a choriocarcinoma case clinically mimicking a primary renal cell carcinoma with multiplex pulmonary metastases. Differentiation from a sarcomatoid renal cell carcinoma with trophoblastic differentiation and identification of the exact origin, namely gestational or germ cell origin by molecular genetic methods is of great importance as it helps determine the prognosis and the most effective therapy of the disease. The Investigator Hexaplex ESS Kit was used for DNA polymorphism studies. This showed foreign alleles in the tumor DNA that confirmed the presence of paternal DNA and the gestational origin of the tumor. |
| doi_str_mv | 10.1177/1066896912444160 |
| format | Article |
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Primary extragenital localization is extremely rare. This report describes a choriocarcinoma case clinically mimicking a primary renal cell carcinoma with multiplex pulmonary metastases. Differentiation from a sarcomatoid renal cell carcinoma with trophoblastic differentiation and identification of the exact origin, namely gestational or germ cell origin by molecular genetic methods is of great importance as it helps determine the prognosis and the most effective therapy of the disease. The Investigator Hexaplex ESS Kit was used for DNA polymorphism studies. 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Primary extragenital localization is extremely rare. This report describes a choriocarcinoma case clinically mimicking a primary renal cell carcinoma with multiplex pulmonary metastases. Differentiation from a sarcomatoid renal cell carcinoma with trophoblastic differentiation and identification of the exact origin, namely gestational or germ cell origin by molecular genetic methods is of great importance as it helps determine the prognosis and the most effective therapy of the disease. The Investigator Hexaplex ESS Kit was used for DNA polymorphism studies. 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Csernák, Erzsébet ; Olasz, Judit ; Küronya, Zsófia ; Szentirmay, Zoltán ; Tóth, Erika</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c290t-524acceea6f9b9630a4448cc0785d2b586bf9f5d5fedd7c89d949256309d07c83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adult</topic><topic>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</topic><topic>Choriocarcinoma - drug therapy</topic><topic>Choriocarcinoma - genetics</topic><topic>Choriocarcinoma - secondary</topic><topic>Chorionic Gonadotropin, beta Subunit, Human - blood</topic><topic>Chromosomes, Human, Y - genetics</topic><topic>Combined Modality Therapy</topic><topic>Diagnosis, Differential</topic><topic>DNA, Neoplasm - analysis</topic><topic>Female</topic><topic>Genotype</topic><topic>Germ Cells - pathology</topic><topic>Humans</topic><topic>Kidney Neoplasms - drug therapy</topic><topic>Kidney Neoplasms - genetics</topic><topic>Kidney Neoplasms - pathology</topic><topic>Lung Neoplasms - drug therapy</topic><topic>Lung Neoplasms - genetics</topic><topic>Lung Neoplasms - secondary</topic><topic>Nephrectomy</topic><topic>Polymorphism, Genetic</topic><topic>Pregnancy</topic><topic>Pregnancy Complications, Neoplastic</topic><topic>Remission Induction</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vereczkey, Ildikó</creatorcontrib><creatorcontrib>Csernák, Erzsébet</creatorcontrib><creatorcontrib>Olasz, Judit</creatorcontrib><creatorcontrib>Küronya, Zsófia</creatorcontrib><creatorcontrib>Szentirmay, Zoltán</creatorcontrib><creatorcontrib>Tóth, Erika</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of surgical pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vereczkey, Ildikó</au><au>Csernák, Erzsébet</au><au>Olasz, Judit</au><au>Küronya, Zsófia</au><au>Szentirmay, Zoltán</au><au>Tóth, Erika</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Renal Choriocarcinoma: Gestational or Germ Cell Origin?</atitle><jtitle>International journal of surgical pathology</jtitle><addtitle>Int J Surg Pathol</addtitle><date>2012-12-01</date><risdate>2012</risdate><volume>20</volume><issue>6</issue><spage>623</spage><epage>628</epage><pages>623-628</pages><issn>1066-8969</issn><eissn>1940-2465</eissn><abstract>Choriocarcinoma is a rare, highly malignant trophoblastic tumor with gestational or, rarely, germ cell origin. Primary extragenital localization is extremely rare. This report describes a choriocarcinoma case clinically mimicking a primary renal cell carcinoma with multiplex pulmonary metastases. Differentiation from a sarcomatoid renal cell carcinoma with trophoblastic differentiation and identification of the exact origin, namely gestational or germ cell origin by molecular genetic methods is of great importance as it helps determine the prognosis and the most effective therapy of the disease. The Investigator Hexaplex ESS Kit was used for DNA polymorphism studies. This showed foreign alleles in the tumor DNA that confirmed the presence of paternal DNA and the gestational origin of the tumor.</abstract><cop>Los Angeles, CA</cop><pub>SAGE Publications</pub><pmid>23172164</pmid><doi>10.1177/1066896912444160</doi><tpages>6</tpages></addata></record> |
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| subjects | Adult Antineoplastic Combined Chemotherapy Protocols - therapeutic use Choriocarcinoma - drug therapy Choriocarcinoma - genetics Choriocarcinoma - secondary Chorionic Gonadotropin, beta Subunit, Human - blood Chromosomes, Human, Y - genetics Combined Modality Therapy Diagnosis, Differential DNA, Neoplasm - analysis Female Genotype Germ Cells - pathology Humans Kidney Neoplasms - drug therapy Kidney Neoplasms - genetics Kidney Neoplasms - pathology Lung Neoplasms - drug therapy Lung Neoplasms - genetics Lung Neoplasms - secondary Nephrectomy Polymorphism, Genetic Pregnancy Pregnancy Complications, Neoplastic Remission Induction Treatment Outcome |
| title | Renal Choriocarcinoma: Gestational or Germ Cell Origin? |
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