Association of Dietary Copper and Zinc Levels with Hepatic Copper and Zinc Concentration in Labrador Retrievers
Background Copper‐associated hepatitis is an inherited disease in the Labrador Retriever. Apart from genetic factors, dietary intake of copper and zinc are suspected to play a role in the pathogenesis. Objectives To investigate whether dietary copper and zinc levels of commercially available dry die...
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| Veröffentlicht in: | Journal of veterinary internal medicine 2012-11, Vol.26 (6), p.1274-1280 |
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| creator | Fieten, H. Hooijer‐Nouwens, B.D. Biourge, V.C. Leegwater, P.A.J. Watson, A.L. den Ingh, T.S.G.A.M. Rothuizen, J. |
| description | Background
Copper‐associated hepatitis is an inherited disease in the Labrador Retriever. Apart from genetic factors, dietary intake of copper and zinc are suspected to play a role in the pathogenesis.
Objectives
To investigate whether dietary copper and zinc levels of commercially available dry diets are associated with hepatic copper and zinc concentrations in Labrador Retrievers.
Animals
Fifty‐five Labrador Retrievers that were fed a single brand and type of commercial dry food for at least 1 year. Of these, 44 dogs were family members of Labrador Retrievers with copper‐associated hepatitis.
Methods
Liver biopsies, blood samples, and diet samples were obtained. Liver specimens were scored histologically and copper and zinc concentrations were quantified. Dietary concentrations of copper and zinc were measured. The association between dietary intake of copper and zinc and hepatic copper and zinc concentrations was investigated by linear regression analysis.
Results
High dietary copper and low dietary zinc levels were significantly associated with high hepatic copper levels. No association between dietary intake and hepatic zinc was present.
Conclusions and Clinical Relevance
Dietary copper and zinc at current levels in commercially available dry dog food can influence hepatic copper and can be a risk factor for the development of copper‐associated hepatitis in Labrador Retrievers with a genetic susceptibility to copper. |
| doi_str_mv | 10.1111/j.1939-1676.2012.01001.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_24P</sourceid><recordid>TN_cdi_proquest_miscellaneous_1186923426</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3067664017</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4481-48b84a3283e6b155376c14d731a82270e20e0631f44d7bb76dcc70e6c211ce03</originalsourceid><addsrcrecordid>eNqNkU9P3DAQxa0KVJZtv0JlqRcuST124jiXSmhp-aNFSNWKAxfLcWZVr7JxsLMFvn2dLuUAF3wZa-Y3z9Z7hFBgOaTzbZNDLeoMZCVzzoDnDBiD_PEDmb0MDsiMqRoyKQt2RI5j3DDGy7KsPpIjzutaAa9mxJ_G6K0zo_M99Wt65nA04Yku_DBgoKZv6Z3rLV3iH-wifXDjb3qBQ-LtG2bhe4v9GPZirqdL0wTT-kB_4RhcUgjxEzlcmy7i5-c6J6ufP1aLi2x5c365OF1mtigUZIVqVGEEVwJlA2UpKmmhaCsBRnFeMeQMmRSwLlKzaSrZWpu60nIAi0zMycledgj-fodx1FsXLXad6dHvogZQsuai4DKhX1-hG78LffqcFiz5mOyDKlFqT9ngYwy41kNw2-SUBqanTPRGT9bryXo9ZaL_ZaIf0-qX5wd2zRbbl8X_ISTg-x54cB0-vVtYX91eXk9X8RcFXJmC</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3067664017</pqid></control><display><type>article</type><title>Association of Dietary Copper and Zinc Levels with Hepatic Copper and Zinc Concentration in Labrador Retrievers</title><source>Wiley Online Library Open Access</source><creator>Fieten, H. ; Hooijer‐Nouwens, B.D. ; Biourge, V.C. ; Leegwater, P.A.J. ; Watson, A.L. ; den Ingh, T.S.G.A.M. ; Rothuizen, J.</creator><creatorcontrib>Fieten, H. ; Hooijer‐Nouwens, B.D. ; Biourge, V.C. ; Leegwater, P.A.J. ; Watson, A.L. ; den Ingh, T.S.G.A.M. ; Rothuizen, J.</creatorcontrib><description>Background
Copper‐associated hepatitis is an inherited disease in the Labrador Retriever. Apart from genetic factors, dietary intake of copper and zinc are suspected to play a role in the pathogenesis.
Objectives
To investigate whether dietary copper and zinc levels of commercially available dry diets are associated with hepatic copper and zinc concentrations in Labrador Retrievers.
Animals
Fifty‐five Labrador Retrievers that were fed a single brand and type of commercial dry food for at least 1 year. Of these, 44 dogs were family members of Labrador Retrievers with copper‐associated hepatitis.
Methods
Liver biopsies, blood samples, and diet samples were obtained. Liver specimens were scored histologically and copper and zinc concentrations were quantified. Dietary concentrations of copper and zinc were measured. The association between dietary intake of copper and zinc and hepatic copper and zinc concentrations was investigated by linear regression analysis.
Results
High dietary copper and low dietary zinc levels were significantly associated with high hepatic copper levels. No association between dietary intake and hepatic zinc was present.
Conclusions and Clinical Relevance
Dietary copper and zinc at current levels in commercially available dry dog food can influence hepatic copper and can be a risk factor for the development of copper‐associated hepatitis in Labrador Retrievers with a genetic susceptibility to copper.</description><identifier>ISSN: 0891-6640</identifier><identifier>EISSN: 1939-1676</identifier><identifier>DOI: 10.1111/j.1939-1676.2012.01001.x</identifier><identifier>PMID: 22998127</identifier><language>eng</language><publisher>United States: John Wiley & Sons, Inc</publisher><subject>Animal Feed - analysis ; Animal Nutritional Physiological Phenomena ; Animals ; Biopsy ; Chemical and Drug Induced Liver Injury - genetics ; Chemical and Drug Induced Liver Injury - pathology ; Chemical and Drug Induced Liver Injury - veterinary ; Copper ; Copper - chemistry ; Copper - metabolism ; Diet ; Diet - veterinary ; Dog ; Dog Diseases - chemically induced ; Dog Diseases - genetics ; Dogs ; Female ; Hepatitis ; Liver ; Liver - chemistry ; Liver - metabolism ; Liver - pathology ; Liver cirrhosis ; Liver diseases ; Male ; Neutrons ; Wilson's disease ; Zinc - chemistry ; Zinc - metabolism</subject><ispartof>Journal of veterinary internal medicine, 2012-11, Vol.26 (6), p.1274-1280</ispartof><rights>Copyright © 2012 by the American College of Veterinary Internal Medicine</rights><rights>Copyright © 2012 by the American College of Veterinary Internal Medicine.</rights><rights>2012. This work is published under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4481-48b84a3283e6b155376c14d731a82270e20e0631f44d7bb76dcc70e6c211ce03</citedby><cites>FETCH-LOGICAL-c4481-48b84a3283e6b155376c14d731a82270e20e0631f44d7bb76dcc70e6c211ce03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1939-1676.2012.01001.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1939-1676.2012.01001.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,11541,27901,27902,45550,45551,46027,46451</link.rule.ids><linktorsrc>$$Uhttps://onlinelibrary.wiley.com/doi/abs/10.1111%2Fj.1939-1676.2012.01001.x$$EView_record_in_Wiley-Blackwell$$FView_record_in_$$GWiley-Blackwell</linktorsrc><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22998127$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fieten, H.</creatorcontrib><creatorcontrib>Hooijer‐Nouwens, B.D.</creatorcontrib><creatorcontrib>Biourge, V.C.</creatorcontrib><creatorcontrib>Leegwater, P.A.J.</creatorcontrib><creatorcontrib>Watson, A.L.</creatorcontrib><creatorcontrib>den Ingh, T.S.G.A.M.</creatorcontrib><creatorcontrib>Rothuizen, J.</creatorcontrib><title>Association of Dietary Copper and Zinc Levels with Hepatic Copper and Zinc Concentration in Labrador Retrievers</title><title>Journal of veterinary internal medicine</title><addtitle>J Vet Intern Med</addtitle><description>Background
Copper‐associated hepatitis is an inherited disease in the Labrador Retriever. Apart from genetic factors, dietary intake of copper and zinc are suspected to play a role in the pathogenesis.
Objectives
To investigate whether dietary copper and zinc levels of commercially available dry diets are associated with hepatic copper and zinc concentrations in Labrador Retrievers.
Animals
Fifty‐five Labrador Retrievers that were fed a single brand and type of commercial dry food for at least 1 year. Of these, 44 dogs were family members of Labrador Retrievers with copper‐associated hepatitis.
Methods
Liver biopsies, blood samples, and diet samples were obtained. Liver specimens were scored histologically and copper and zinc concentrations were quantified. Dietary concentrations of copper and zinc were measured. The association between dietary intake of copper and zinc and hepatic copper and zinc concentrations was investigated by linear regression analysis.
Results
High dietary copper and low dietary zinc levels were significantly associated with high hepatic copper levels. No association between dietary intake and hepatic zinc was present.
Conclusions and Clinical Relevance
Dietary copper and zinc at current levels in commercially available dry dog food can influence hepatic copper and can be a risk factor for the development of copper‐associated hepatitis in Labrador Retrievers with a genetic susceptibility to copper.</description><subject>Animal Feed - analysis</subject><subject>Animal Nutritional Physiological Phenomena</subject><subject>Animals</subject><subject>Biopsy</subject><subject>Chemical and Drug Induced Liver Injury - genetics</subject><subject>Chemical and Drug Induced Liver Injury - pathology</subject><subject>Chemical and Drug Induced Liver Injury - veterinary</subject><subject>Copper</subject><subject>Copper - chemistry</subject><subject>Copper - metabolism</subject><subject>Diet</subject><subject>Diet - veterinary</subject><subject>Dog</subject><subject>Dog Diseases - chemically induced</subject><subject>Dog Diseases - genetics</subject><subject>Dogs</subject><subject>Female</subject><subject>Hepatitis</subject><subject>Liver</subject><subject>Liver - chemistry</subject><subject>Liver - metabolism</subject><subject>Liver - pathology</subject><subject>Liver cirrhosis</subject><subject>Liver diseases</subject><subject>Male</subject><subject>Neutrons</subject><subject>Wilson's disease</subject><subject>Zinc - chemistry</subject><subject>Zinc - metabolism</subject><issn>0891-6640</issn><issn>1939-1676</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU9P3DAQxa0KVJZtv0JlqRcuST124jiXSmhp-aNFSNWKAxfLcWZVr7JxsLMFvn2dLuUAF3wZa-Y3z9Z7hFBgOaTzbZNDLeoMZCVzzoDnDBiD_PEDmb0MDsiMqRoyKQt2RI5j3DDGy7KsPpIjzutaAa9mxJ_G6K0zo_M99Wt65nA04Yku_DBgoKZv6Z3rLV3iH-wifXDjb3qBQ-LtG2bhe4v9GPZirqdL0wTT-kB_4RhcUgjxEzlcmy7i5-c6J6ufP1aLi2x5c365OF1mtigUZIVqVGEEVwJlA2UpKmmhaCsBRnFeMeQMmRSwLlKzaSrZWpu60nIAi0zMycledgj-fodx1FsXLXad6dHvogZQsuai4DKhX1-hG78LffqcFiz5mOyDKlFqT9ngYwy41kNw2-SUBqanTPRGT9bryXo9ZaL_ZaIf0-qX5wd2zRbbl8X_ISTg-x54cB0-vVtYX91eXk9X8RcFXJmC</recordid><startdate>201211</startdate><enddate>201211</enddate><creator>Fieten, H.</creator><creator>Hooijer‐Nouwens, B.D.</creator><creator>Biourge, V.C.</creator><creator>Leegwater, P.A.J.</creator><creator>Watson, A.L.</creator><creator>den Ingh, T.S.G.A.M.</creator><creator>Rothuizen, J.</creator><general>John Wiley & Sons, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201211</creationdate><title>Association of Dietary Copper and Zinc Levels with Hepatic Copper and Zinc Concentration in Labrador Retrievers</title><author>Fieten, H. ; Hooijer‐Nouwens, B.D. ; Biourge, V.C. ; Leegwater, P.A.J. ; Watson, A.L. ; den Ingh, T.S.G.A.M. ; Rothuizen, J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4481-48b84a3283e6b155376c14d731a82270e20e0631f44d7bb76dcc70e6c211ce03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Animal Feed - analysis</topic><topic>Animal Nutritional Physiological Phenomena</topic><topic>Animals</topic><topic>Biopsy</topic><topic>Chemical and Drug Induced Liver Injury - genetics</topic><topic>Chemical and Drug Induced Liver Injury - pathology</topic><topic>Chemical and Drug Induced Liver Injury - veterinary</topic><topic>Copper</topic><topic>Copper - chemistry</topic><topic>Copper - metabolism</topic><topic>Diet</topic><topic>Diet - veterinary</topic><topic>Dog</topic><topic>Dog Diseases - chemically induced</topic><topic>Dog Diseases - genetics</topic><topic>Dogs</topic><topic>Female</topic><topic>Hepatitis</topic><topic>Liver</topic><topic>Liver - chemistry</topic><topic>Liver - metabolism</topic><topic>Liver - pathology</topic><topic>Liver cirrhosis</topic><topic>Liver diseases</topic><topic>Male</topic><topic>Neutrons</topic><topic>Wilson's disease</topic><topic>Zinc - chemistry</topic><topic>Zinc - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fieten, H.</creatorcontrib><creatorcontrib>Hooijer‐Nouwens, B.D.</creatorcontrib><creatorcontrib>Biourge, V.C.</creatorcontrib><creatorcontrib>Leegwater, P.A.J.</creatorcontrib><creatorcontrib>Watson, A.L.</creatorcontrib><creatorcontrib>den Ingh, T.S.G.A.M.</creatorcontrib><creatorcontrib>Rothuizen, J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of veterinary internal medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Fieten, H.</au><au>Hooijer‐Nouwens, B.D.</au><au>Biourge, V.C.</au><au>Leegwater, P.A.J.</au><au>Watson, A.L.</au><au>den Ingh, T.S.G.A.M.</au><au>Rothuizen, J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of Dietary Copper and Zinc Levels with Hepatic Copper and Zinc Concentration in Labrador Retrievers</atitle><jtitle>Journal of veterinary internal medicine</jtitle><addtitle>J Vet Intern Med</addtitle><date>2012-11</date><risdate>2012</risdate><volume>26</volume><issue>6</issue><spage>1274</spage><epage>1280</epage><pages>1274-1280</pages><issn>0891-6640</issn><eissn>1939-1676</eissn><abstract>Background
Copper‐associated hepatitis is an inherited disease in the Labrador Retriever. Apart from genetic factors, dietary intake of copper and zinc are suspected to play a role in the pathogenesis.
Objectives
To investigate whether dietary copper and zinc levels of commercially available dry diets are associated with hepatic copper and zinc concentrations in Labrador Retrievers.
Animals
Fifty‐five Labrador Retrievers that were fed a single brand and type of commercial dry food for at least 1 year. Of these, 44 dogs were family members of Labrador Retrievers with copper‐associated hepatitis.
Methods
Liver biopsies, blood samples, and diet samples were obtained. Liver specimens were scored histologically and copper and zinc concentrations were quantified. Dietary concentrations of copper and zinc were measured. The association between dietary intake of copper and zinc and hepatic copper and zinc concentrations was investigated by linear regression analysis.
Results
High dietary copper and low dietary zinc levels were significantly associated with high hepatic copper levels. No association between dietary intake and hepatic zinc was present.
Conclusions and Clinical Relevance
Dietary copper and zinc at current levels in commercially available dry dog food can influence hepatic copper and can be a risk factor for the development of copper‐associated hepatitis in Labrador Retrievers with a genetic susceptibility to copper.</abstract><cop>United States</cop><pub>John Wiley & Sons, Inc</pub><pmid>22998127</pmid><doi>10.1111/j.1939-1676.2012.01001.x</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0891-6640 |
| ispartof | Journal of veterinary internal medicine, 2012-11, Vol.26 (6), p.1274-1280 |
| issn | 0891-6640 1939-1676 |
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| subjects | Animal Feed - analysis Animal Nutritional Physiological Phenomena Animals Biopsy Chemical and Drug Induced Liver Injury - genetics Chemical and Drug Induced Liver Injury - pathology Chemical and Drug Induced Liver Injury - veterinary Copper Copper - chemistry Copper - metabolism Diet Diet - veterinary Dog Dog Diseases - chemically induced Dog Diseases - genetics Dogs Female Hepatitis Liver Liver - chemistry Liver - metabolism Liver - pathology Liver cirrhosis Liver diseases Male Neutrons Wilson's disease Zinc - chemistry Zinc - metabolism |
| title | Association of Dietary Copper and Zinc Levels with Hepatic Copper and Zinc Concentration in Labrador Retrievers |
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