Prospective Evaluation of NT‐proBNP Assay to Detect Occult Dilated Cardiomyopathy and Predict Survival in Doberman Pinschers
Background Occult (asymptomatic) dilated cardiomyopathy (ODCM) is highly prevalent in Doberman Pinschers. Hypothesis/Objectives Assess ability of NT‐proBNP assay to detect ODCM and predict death. Animals 155 asymptomatic Dobermans presenting for ODCM screening. Methods Echocardiography, 24‐hour Holt...
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| Veröffentlicht in: | Journal of veterinary internal medicine 2012-11, Vol.26 (6), p.1330-1336 |
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| creator | Singletary, G.E. Morris, N.A. Lynne O'Sullivan, M. Gordon, S.G. Oyama, M.A. |
| description | Background
Occult (asymptomatic) dilated cardiomyopathy (ODCM) is highly prevalent in Doberman Pinschers.
Hypothesis/Objectives
Assess ability of NT‐proBNP assay to detect ODCM and predict death.
Animals
155 asymptomatic Dobermans presenting for ODCM screening.
Methods
Echocardiography, 24‐hour Holter, and NT‐proBNP assay were performed prospectively. Diagnosis was based on increased left ventricular end‐systolic dimension, >50 ventricular premature complexes (VPCs), or both on Holter. Utility was evaluated using receiver‐operating characteristic curves. Effect of age, weight, sex, disease status, VPCs, and NT‐proBNP on survival was analyzed using Kaplan‐Meier and Cox‐proportional hazard analysis.
Results
Seventy‐three (47.1%) Dobermans were diagnosed with ODCM, including 31, 17, and 25 that met Holter, echocardiographic, or both criteria, respectively. Sensitivity of NT‐proBNP > 457 pmol/L to detect these groups was 45.2, 76.5, and 96.0%, respectively. Combination of NT‐proBNP and Holter to detect ODCM yielded sensitivity of 94.5%, specificity of 87.8%, and accuracy of 91.0%. Follow‐up data were available for 78 Dobermans. The median survival time of Dobermans with > 50 VPCs (469 days), NT‐proBNP > 900 pmol/L (284 days), or ODCM (474 days) was significantly (P |
| doi_str_mv | 10.1111/j.1939-1676.2012.1000.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_24P</sourceid><recordid>TN_cdi_proquest_miscellaneous_1186923387</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3067665929</sourcerecordid><originalsourceid>FETCH-LOGICAL-p2930-f223f31fe162fa532c80adf5ae0f48e4b0a55465b86f00366724e4d720a78e8f3</originalsourceid><addsrcrecordid>eNpdkcFu1DAQhi0EotuFVwBLXLgkjO3EiQ8cym5bikq7EoWr5U1s1askTu1k21yqPgLPyJPgqKUHfLE1_jT6Zz6E3hNISTyfdikRTCSEFzylQGhKACC9e4EWz_WXaAGlIAnnGRygwxB2ADTP8-I1OqBUiBIELND9xrvQ62qwe42P96oZ1WBdh53BF1d_Hn733n252OCjENSEB4fXeogwvqyqsRnw2jZq0DVeKV9b106uV8P1hFVX443XtY3kj9HvbeyLbYfXbqt9qzq8sV2orrUPb9Aro5qg3z7dS_Tz5Phq9TU5vzw9Wx2dJz0VDBJDKTOMGE04NSpntCpB1SZXGkxW6mwLKs8znm9LbgAY5wXNdFYXFFRR6tKwJfr42DfOczPqMMjWhko3jeq0G4MkpOSCMlYWEf3wH7pzo-9iOskg7pXnImZaondP1LhtdS17b1vlJ_lvsxH4_Ajc2kZPz_8E5CxQ7uQsSs6i5CxQzgLlnfz26-z7_GR_Adg2j3c</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3067665929</pqid></control><display><type>article</type><title>Prospective Evaluation of NT‐proBNP Assay to Detect Occult Dilated Cardiomyopathy and Predict Survival in Doberman Pinschers</title><source>Wiley Online Library Open Access</source><creator>Singletary, G.E. ; Morris, N.A. ; Lynne O'Sullivan, M. ; Gordon, S.G. ; Oyama, M.A.</creator><creatorcontrib>Singletary, G.E. ; Morris, N.A. ; Lynne O'Sullivan, M. ; Gordon, S.G. ; Oyama, M.A.</creatorcontrib><description>Background
Occult (asymptomatic) dilated cardiomyopathy (ODCM) is highly prevalent in Doberman Pinschers.
Hypothesis/Objectives
Assess ability of NT‐proBNP assay to detect ODCM and predict death.
Animals
155 asymptomatic Dobermans presenting for ODCM screening.
Methods
Echocardiography, 24‐hour Holter, and NT‐proBNP assay were performed prospectively. Diagnosis was based on increased left ventricular end‐systolic dimension, >50 ventricular premature complexes (VPCs), or both on Holter. Utility was evaluated using receiver‐operating characteristic curves. Effect of age, weight, sex, disease status, VPCs, and NT‐proBNP on survival was analyzed using Kaplan‐Meier and Cox‐proportional hazard analysis.
Results
Seventy‐three (47.1%) Dobermans were diagnosed with ODCM, including 31, 17, and 25 that met Holter, echocardiographic, or both criteria, respectively. Sensitivity of NT‐proBNP > 457 pmol/L to detect these groups was 45.2, 76.5, and 96.0%, respectively. Combination of NT‐proBNP and Holter to detect ODCM yielded sensitivity of 94.5%, specificity of 87.8%, and accuracy of 91.0%. Follow‐up data were available for 78 Dobermans. The median survival time of Dobermans with > 50 VPCs (469 days), NT‐proBNP > 900 pmol/L (284 days), or ODCM (474 days) was significantly (P < .0001) shorter than those with < 50 VPCs (1743 days), NT‐proBNP < 900 pmol/L (1743 days), or without disease (1743 days). NT‐proBNP concentration and disease status were independently predictive of all‐cause mortality.
Conclusions and Clinical Importance
The combination of NT‐proBNP assay and Holter detected ODCM with high accuracy. NT‐proBNP and disease status were independently associated with survival. NT‐proBNP assay identified Dobermans with high probability of increased LVIDs consistent with ODCM, and can facilitate pursuit of confirmatory diagnostic testing, such as echocardiography, in suspected Dobermans.</description><identifier>ISSN: 0891-6640</identifier><identifier>EISSN: 1939-1676</identifier><identifier>DOI: 10.1111/j.1939-1676.2012.1000.x</identifier><identifier>PMID: 22998090</identifier><language>eng</language><publisher>United States: John Wiley & Sons, Inc</publisher><subject>Animals ; Blood tests ; BNP ; Cardiology ; Cardiomyopathy ; Cardiomyopathy, Dilated - blood ; Cardiomyopathy, Dilated - diagnosis ; Cardiomyopathy, Dilated - mortality ; Cardiomyopathy, Dilated - veterinary ; Diagnostics ; Disease ; Dog Diseases - blood ; Dog Diseases - diagnosis ; Dog Diseases - mortality ; Dogs ; Epidemiology ; Female ; Heart disease ; Heart failure ; Kaplan-Meier Estimate ; Longevity ; Male ; Medical prognosis ; Natriuretic Peptide, Brain - blood ; Natriuretic peptides ; Peptide Fragments - blood ; Peptides ; Plasma ; Proportional Hazards Models ; Risk Factors ; Sensitivity and Specificity</subject><ispartof>Journal of veterinary internal medicine, 2012-11, Vol.26 (6), p.1330-1336</ispartof><rights>Copyright © 2012 by the American College of Veterinary Internal Medicine</rights><rights>Copyright © 2012 by the American College of Veterinary Internal Medicine.</rights><rights>2012. This work is published under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1939-1676.2012.1000.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1939-1676.2012.1000.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,11541,27901,27902,45550,45551,46027,46451</link.rule.ids><linktorsrc>$$Uhttps://onlinelibrary.wiley.com/doi/abs/10.1111%2Fj.1939-1676.2012.1000.x$$EView_record_in_Wiley-Blackwell$$FView_record_in_$$GWiley-Blackwell</linktorsrc><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22998090$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Singletary, G.E.</creatorcontrib><creatorcontrib>Morris, N.A.</creatorcontrib><creatorcontrib>Lynne O'Sullivan, M.</creatorcontrib><creatorcontrib>Gordon, S.G.</creatorcontrib><creatorcontrib>Oyama, M.A.</creatorcontrib><title>Prospective Evaluation of NT‐proBNP Assay to Detect Occult Dilated Cardiomyopathy and Predict Survival in Doberman Pinschers</title><title>Journal of veterinary internal medicine</title><addtitle>J Vet Intern Med</addtitle><description>Background
Occult (asymptomatic) dilated cardiomyopathy (ODCM) is highly prevalent in Doberman Pinschers.
Hypothesis/Objectives
Assess ability of NT‐proBNP assay to detect ODCM and predict death.
Animals
155 asymptomatic Dobermans presenting for ODCM screening.
Methods
Echocardiography, 24‐hour Holter, and NT‐proBNP assay were performed prospectively. Diagnosis was based on increased left ventricular end‐systolic dimension, >50 ventricular premature complexes (VPCs), or both on Holter. Utility was evaluated using receiver‐operating characteristic curves. Effect of age, weight, sex, disease status, VPCs, and NT‐proBNP on survival was analyzed using Kaplan‐Meier and Cox‐proportional hazard analysis.
Results
Seventy‐three (47.1%) Dobermans were diagnosed with ODCM, including 31, 17, and 25 that met Holter, echocardiographic, or both criteria, respectively. Sensitivity of NT‐proBNP > 457 pmol/L to detect these groups was 45.2, 76.5, and 96.0%, respectively. Combination of NT‐proBNP and Holter to detect ODCM yielded sensitivity of 94.5%, specificity of 87.8%, and accuracy of 91.0%. Follow‐up data were available for 78 Dobermans. The median survival time of Dobermans with > 50 VPCs (469 days), NT‐proBNP > 900 pmol/L (284 days), or ODCM (474 days) was significantly (P < .0001) shorter than those with < 50 VPCs (1743 days), NT‐proBNP < 900 pmol/L (1743 days), or without disease (1743 days). NT‐proBNP concentration and disease status were independently predictive of all‐cause mortality.
Conclusions and Clinical Importance
The combination of NT‐proBNP assay and Holter detected ODCM with high accuracy. NT‐proBNP and disease status were independently associated with survival. NT‐proBNP assay identified Dobermans with high probability of increased LVIDs consistent with ODCM, and can facilitate pursuit of confirmatory diagnostic testing, such as echocardiography, in suspected Dobermans.</description><subject>Animals</subject><subject>Blood tests</subject><subject>BNP</subject><subject>Cardiology</subject><subject>Cardiomyopathy</subject><subject>Cardiomyopathy, Dilated - blood</subject><subject>Cardiomyopathy, Dilated - diagnosis</subject><subject>Cardiomyopathy, Dilated - mortality</subject><subject>Cardiomyopathy, Dilated - veterinary</subject><subject>Diagnostics</subject><subject>Disease</subject><subject>Dog Diseases - blood</subject><subject>Dog Diseases - diagnosis</subject><subject>Dog Diseases - mortality</subject><subject>Dogs</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Heart disease</subject><subject>Heart failure</subject><subject>Kaplan-Meier Estimate</subject><subject>Longevity</subject><subject>Male</subject><subject>Medical prognosis</subject><subject>Natriuretic Peptide, Brain - blood</subject><subject>Natriuretic peptides</subject><subject>Peptide Fragments - blood</subject><subject>Peptides</subject><subject>Plasma</subject><subject>Proportional Hazards Models</subject><subject>Risk Factors</subject><subject>Sensitivity and Specificity</subject><issn>0891-6640</issn><issn>1939-1676</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkcFu1DAQhi0EotuFVwBLXLgkjO3EiQ8cym5bikq7EoWr5U1s1askTu1k21yqPgLPyJPgqKUHfLE1_jT6Zz6E3hNISTyfdikRTCSEFzylQGhKACC9e4EWz_WXaAGlIAnnGRygwxB2ADTP8-I1OqBUiBIELND9xrvQ62qwe42P96oZ1WBdh53BF1d_Hn733n252OCjENSEB4fXeogwvqyqsRnw2jZq0DVeKV9b106uV8P1hFVX443XtY3kj9HvbeyLbYfXbqt9qzq8sV2orrUPb9Aro5qg3z7dS_Tz5Phq9TU5vzw9Wx2dJz0VDBJDKTOMGE04NSpntCpB1SZXGkxW6mwLKs8znm9LbgAY5wXNdFYXFFRR6tKwJfr42DfOczPqMMjWhko3jeq0G4MkpOSCMlYWEf3wH7pzo-9iOskg7pXnImZaondP1LhtdS17b1vlJ_lvsxH4_Ajc2kZPz_8E5CxQ7uQsSs6i5CxQzgLlnfz26-z7_GR_Adg2j3c</recordid><startdate>201211</startdate><enddate>201211</enddate><creator>Singletary, G.E.</creator><creator>Morris, N.A.</creator><creator>Lynne O'Sullivan, M.</creator><creator>Gordon, S.G.</creator><creator>Oyama, M.A.</creator><general>John Wiley & Sons, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201211</creationdate><title>Prospective Evaluation of NT‐proBNP Assay to Detect Occult Dilated Cardiomyopathy and Predict Survival in Doberman Pinschers</title><author>Singletary, G.E. ; Morris, N.A. ; Lynne O'Sullivan, M. ; Gordon, S.G. ; Oyama, M.A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p2930-f223f31fe162fa532c80adf5ae0f48e4b0a55465b86f00366724e4d720a78e8f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Animals</topic><topic>Blood tests</topic><topic>BNP</topic><topic>Cardiology</topic><topic>Cardiomyopathy</topic><topic>Cardiomyopathy, Dilated - blood</topic><topic>Cardiomyopathy, Dilated - diagnosis</topic><topic>Cardiomyopathy, Dilated - mortality</topic><topic>Cardiomyopathy, Dilated - veterinary</topic><topic>Diagnostics</topic><topic>Disease</topic><topic>Dog Diseases - blood</topic><topic>Dog Diseases - diagnosis</topic><topic>Dog Diseases - mortality</topic><topic>Dogs</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Heart disease</topic><topic>Heart failure</topic><topic>Kaplan-Meier Estimate</topic><topic>Longevity</topic><topic>Male</topic><topic>Medical prognosis</topic><topic>Natriuretic Peptide, Brain - blood</topic><topic>Natriuretic peptides</topic><topic>Peptide Fragments - blood</topic><topic>Peptides</topic><topic>Plasma</topic><topic>Proportional Hazards Models</topic><topic>Risk Factors</topic><topic>Sensitivity and Specificity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Singletary, G.E.</creatorcontrib><creatorcontrib>Morris, N.A.</creatorcontrib><creatorcontrib>Lynne O'Sullivan, M.</creatorcontrib><creatorcontrib>Gordon, S.G.</creatorcontrib><creatorcontrib>Oyama, M.A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of veterinary internal medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Singletary, G.E.</au><au>Morris, N.A.</au><au>Lynne O'Sullivan, M.</au><au>Gordon, S.G.</au><au>Oyama, M.A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prospective Evaluation of NT‐proBNP Assay to Detect Occult Dilated Cardiomyopathy and Predict Survival in Doberman Pinschers</atitle><jtitle>Journal of veterinary internal medicine</jtitle><addtitle>J Vet Intern Med</addtitle><date>2012-11</date><risdate>2012</risdate><volume>26</volume><issue>6</issue><spage>1330</spage><epage>1336</epage><pages>1330-1336</pages><issn>0891-6640</issn><eissn>1939-1676</eissn><abstract>Background
Occult (asymptomatic) dilated cardiomyopathy (ODCM) is highly prevalent in Doberman Pinschers.
Hypothesis/Objectives
Assess ability of NT‐proBNP assay to detect ODCM and predict death.
Animals
155 asymptomatic Dobermans presenting for ODCM screening.
Methods
Echocardiography, 24‐hour Holter, and NT‐proBNP assay were performed prospectively. Diagnosis was based on increased left ventricular end‐systolic dimension, >50 ventricular premature complexes (VPCs), or both on Holter. Utility was evaluated using receiver‐operating characteristic curves. Effect of age, weight, sex, disease status, VPCs, and NT‐proBNP on survival was analyzed using Kaplan‐Meier and Cox‐proportional hazard analysis.
Results
Seventy‐three (47.1%) Dobermans were diagnosed with ODCM, including 31, 17, and 25 that met Holter, echocardiographic, or both criteria, respectively. Sensitivity of NT‐proBNP > 457 pmol/L to detect these groups was 45.2, 76.5, and 96.0%, respectively. Combination of NT‐proBNP and Holter to detect ODCM yielded sensitivity of 94.5%, specificity of 87.8%, and accuracy of 91.0%. Follow‐up data were available for 78 Dobermans. The median survival time of Dobermans with > 50 VPCs (469 days), NT‐proBNP > 900 pmol/L (284 days), or ODCM (474 days) was significantly (P < .0001) shorter than those with < 50 VPCs (1743 days), NT‐proBNP < 900 pmol/L (1743 days), or without disease (1743 days). NT‐proBNP concentration and disease status were independently predictive of all‐cause mortality.
Conclusions and Clinical Importance
The combination of NT‐proBNP assay and Holter detected ODCM with high accuracy. NT‐proBNP and disease status were independently associated with survival. NT‐proBNP assay identified Dobermans with high probability of increased LVIDs consistent with ODCM, and can facilitate pursuit of confirmatory diagnostic testing, such as echocardiography, in suspected Dobermans.</abstract><cop>United States</cop><pub>John Wiley & Sons, Inc</pub><pmid>22998090</pmid><doi>10.1111/j.1939-1676.2012.1000.x</doi><tpages>7</tpages></addata></record> |
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| subjects | Animals Blood tests BNP Cardiology Cardiomyopathy Cardiomyopathy, Dilated - blood Cardiomyopathy, Dilated - diagnosis Cardiomyopathy, Dilated - mortality Cardiomyopathy, Dilated - veterinary Diagnostics Disease Dog Diseases - blood Dog Diseases - diagnosis Dog Diseases - mortality Dogs Epidemiology Female Heart disease Heart failure Kaplan-Meier Estimate Longevity Male Medical prognosis Natriuretic Peptide, Brain - blood Natriuretic peptides Peptide Fragments - blood Peptides Plasma Proportional Hazards Models Risk Factors Sensitivity and Specificity |
| title | Prospective Evaluation of NT‐proBNP Assay to Detect Occult Dilated Cardiomyopathy and Predict Survival in Doberman Pinschers |
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