Anti-angiogenic effect of luteolin on retinal neovascularization via blockade of reactive oxygen species production

Oxidative stress-induced vascular endothelial growth factor (VEGF) is thought to play a critical role in the pathogenesis of retinopathy of prematurity (ROP). This study was performed to investigate the anti-angiogenic effect of luteolin against reactive oxygen species (ROS)-induced retinal neovascu...

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Veröffentlicht in:	Investigative ophthalmology & visual science 2012-11, Vol.53 (12), p.7718-7726
Hauptverfasser:	Park, Sung Wook, Cho, Chang Sik, Jun, Hyoung Oh, Ryu, Nam Hee, Kim, Jin Hyoung, Yu, Young Suk, Kim, Jin Sook, Kim, Jeong Hun
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Blotting, Western Cell Survival Cells, Cultured Disease Models, Animal Down-Regulation Fluorescein Angiography Fundus Oculi Humans In Situ Nick-End Labeling Luteolin - therapeutic use Mice Mice, Inbred BALB C Mice, Inbred C57BL Oxidative Stress Reactive Oxygen Species - antagonists & inhibitors Reactive Oxygen Species - metabolism Retina - drug effects Retina - metabolism Retina - pathology Retinal Neovascularization - drug therapy Retinal Neovascularization - metabolism Retinal Neovascularization - pathology RNA, Messenger - biosynthesis RNA, Messenger - genetics Vascular Endothelial Growth Factor A - biosynthesis Vascular Endothelial Growth Factor A - genetics
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