Executive function in early- and adult onset schizophrenia
Abstract Background The goal of this study was to investigate differences in executive functioning between patients with early-onset and adult-onset schizophrenia spectrum psychoses at the time of first treatment. Methods Neuropsychological tests covering executive functioning domains were performed...
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| Veröffentlicht in: | Schizophrenia research 2012-12, Vol.142 (1), p.177-182 |
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| creator | Holmén, Aina Juuhl-Langseth, Monica Thormodsen, Rune Ueland, Torill Agartz, Ingrid Sundet, Kjetil Andreassen, Ole A Rund, Bjørn Rishovd Melle, Ingrid |
| description | Abstract Background The goal of this study was to investigate differences in executive functioning between patients with early-onset and adult-onset schizophrenia spectrum psychoses at the time of first treatment. Methods Neuropsychological tests covering executive functioning domains were performed for 20 adolescents with early-onset schizophrenia (EOS) close to first treatment and 90 first episode patients with adult onset schizophrenia (AOS) in addition to 66 adolescent- and 127 adult age and gender matched healthy controls. Results Both EOS and AOS patients had significantly poorer executive performance than their age- and gender matched healthy counterparts. Both healthy adolescent controls and EOS patients had poorer executive performance than their adult counterparts. However, there were no differences in executive functioning between EOS and AOS patients after controlling for the levels of their age matched healthy control groups. Substituting EOS/AOS status with other age-at-onset thresholds had no effect. Conclusions We find the same relative levels of executive dysfunction in EOS- and AOS groups at the time of first treatment. This does not necessarily contradict previous findings of more severe dysfunction in EOS patients over time, but indicates an interaction between the disorder and the maturational processes that only can be investigated through longitudinal studies. |
| doi_str_mv | 10.1016/j.schres.2012.10.006 |
| format | Article |
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Methods Neuropsychological tests covering executive functioning domains were performed for 20 adolescents with early-onset schizophrenia (EOS) close to first treatment and 90 first episode patients with adult onset schizophrenia (AOS) in addition to 66 adolescent- and 127 adult age and gender matched healthy controls. Results Both EOS and AOS patients had significantly poorer executive performance than their age- and gender matched healthy counterparts. Both healthy adolescent controls and EOS patients had poorer executive performance than their adult counterparts. However, there were no differences in executive functioning between EOS and AOS patients after controlling for the levels of their age matched healthy control groups. Substituting EOS/AOS status with other age-at-onset thresholds had no effect. Conclusions We find the same relative levels of executive dysfunction in EOS- and AOS groups at the time of first treatment. This does not necessarily contradict previous findings of more severe dysfunction in EOS patients over time, but indicates an interaction between the disorder and the maturational processes that only can be investigated through longitudinal studies.</description><identifier>ISSN: 0920-9964</identifier><identifier>EISSN: 1573-2509</identifier><identifier>DOI: 10.1016/j.schres.2012.10.006</identifier><identifier>PMID: 23102692</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Adolescent ; Adult ; Adult and adolescent clinical studies ; Age of Onset ; Aged ; Analysis of Variance ; Biological and medical sciences ; Child ; Cognition Disorders - diagnosis ; Cognition Disorders - etiology ; Early onset ; Executive Function - physiology ; Executive functioning ; Female ; First episode psychosis ; Humans ; Male ; Medical sciences ; Middle Aged ; Neurocognition ; Psychiatric Status Rating Scales ; Psychiatry ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Psychoses ; Schizophrenia ; Schizophrenia - complications ; Schizophrenic Psychology ; Young Adult</subject><ispartof>Schizophrenia research, 2012-12, Vol.142 (1), p.177-182</ispartof><rights>Elsevier B.V.</rights><rights>2012 Elsevier B.V.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2012 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c447t-fd7279fccee1b5435db2f354c2a6f48071a4d27bac78ef6df406546f9c8575953</citedby><cites>FETCH-LOGICAL-c447t-fd7279fccee1b5435db2f354c2a6f48071a4d27bac78ef6df406546f9c8575953</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.schres.2012.10.006$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26680373$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23102692$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Holmén, Aina</creatorcontrib><creatorcontrib>Juuhl-Langseth, Monica</creatorcontrib><creatorcontrib>Thormodsen, Rune</creatorcontrib><creatorcontrib>Ueland, Torill</creatorcontrib><creatorcontrib>Agartz, Ingrid</creatorcontrib><creatorcontrib>Sundet, Kjetil</creatorcontrib><creatorcontrib>Andreassen, Ole A</creatorcontrib><creatorcontrib>Rund, Bjørn Rishovd</creatorcontrib><creatorcontrib>Melle, Ingrid</creatorcontrib><title>Executive function in early- and adult onset schizophrenia</title><title>Schizophrenia research</title><addtitle>Schizophr Res</addtitle><description>Abstract Background The goal of this study was to investigate differences in executive functioning between patients with early-onset and adult-onset schizophrenia spectrum psychoses at the time of first treatment. Methods Neuropsychological tests covering executive functioning domains were performed for 20 adolescents with early-onset schizophrenia (EOS) close to first treatment and 90 first episode patients with adult onset schizophrenia (AOS) in addition to 66 adolescent- and 127 adult age and gender matched healthy controls. Results Both EOS and AOS patients had significantly poorer executive performance than their age- and gender matched healthy counterparts. Both healthy adolescent controls and EOS patients had poorer executive performance than their adult counterparts. However, there were no differences in executive functioning between EOS and AOS patients after controlling for the levels of their age matched healthy control groups. Substituting EOS/AOS status with other age-at-onset thresholds had no effect. Conclusions We find the same relative levels of executive dysfunction in EOS- and AOS groups at the time of first treatment. This does not necessarily contradict previous findings of more severe dysfunction in EOS patients over time, but indicates an interaction between the disorder and the maturational processes that only can be investigated through longitudinal studies.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Age of Onset</subject><subject>Aged</subject><subject>Analysis of Variance</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Cognition Disorders - diagnosis</subject><subject>Cognition Disorders - etiology</subject><subject>Early onset</subject><subject>Executive Function - physiology</subject><subject>Executive functioning</subject><subject>Female</subject><subject>First episode psychosis</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neurocognition</subject><subject>Psychiatric Status Rating Scales</subject><subject>Psychiatry</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Psychoses</subject><subject>Schizophrenia</subject><subject>Schizophrenia - complications</subject><subject>Schizophrenic Psychology</subject><subject>Young Adult</subject><issn>0920-9964</issn><issn>1573-2509</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU2LFDEQhoMo7rj6D0T6Iuylx0o6Hx0PgizrKizsYfUcMkkFM_akx6R7cfz1m2bGFbx4Kiieqrd4ipDXFNYUqHy3XRf3PWNZM6CsttYA8glZUaG6lgnQT8kKNINWa8nPyItStgBABajn5Ix1FJjUbEXeX_1CN0_xHpswJzfFMTUxNWjzcGgbm3xj_TxMzZgKTk1NjL_HfY1N0b4kz4IdCr461XPy7dPV18vP7c3t9ZfLjzet41xNbfCKKR2cQ6QbwTvhNyx0gjtmZeA9KGq5Z2pjneoxSB84SMFl0K4XSmjRnZOL4959Hn_OWCazi8XhMNiE41wMpUpzLVnPK8qPqMtjKRmD2ee4s_lgKJjFmtmaozWzWFu61Vode3NKmDc79I9DfzRV4O0JsMXZIWSbXCx_OSl76FRXuQ9HDquP-4i5pkVMDn3M6Cbjx_i_S_5d4IaYYs38gQcs23HOqbo21BRmwNwtH14eTBmAUL3sHgDZ_aDm</recordid><startdate>20121201</startdate><enddate>20121201</enddate><creator>Holmén, Aina</creator><creator>Juuhl-Langseth, Monica</creator><creator>Thormodsen, Rune</creator><creator>Ueland, Torill</creator><creator>Agartz, Ingrid</creator><creator>Sundet, Kjetil</creator><creator>Andreassen, Ole A</creator><creator>Rund, Bjørn Rishovd</creator><creator>Melle, Ingrid</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20121201</creationdate><title>Executive function in early- and adult onset schizophrenia</title><author>Holmén, Aina ; Juuhl-Langseth, Monica ; Thormodsen, Rune ; Ueland, Torill ; Agartz, Ingrid ; Sundet, Kjetil ; Andreassen, Ole A ; Rund, Bjørn Rishovd ; Melle, Ingrid</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c447t-fd7279fccee1b5435db2f354c2a6f48071a4d27bac78ef6df406546f9c8575953</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>Age of Onset</topic><topic>Aged</topic><topic>Analysis of Variance</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Cognition Disorders - diagnosis</topic><topic>Cognition Disorders - etiology</topic><topic>Early onset</topic><topic>Executive Function - physiology</topic><topic>Executive functioning</topic><topic>Female</topic><topic>First episode psychosis</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neurocognition</topic><topic>Psychiatric Status Rating Scales</topic><topic>Psychiatry</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Psychoses</topic><topic>Schizophrenia</topic><topic>Schizophrenia - complications</topic><topic>Schizophrenic Psychology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Holmén, Aina</creatorcontrib><creatorcontrib>Juuhl-Langseth, Monica</creatorcontrib><creatorcontrib>Thormodsen, Rune</creatorcontrib><creatorcontrib>Ueland, Torill</creatorcontrib><creatorcontrib>Agartz, Ingrid</creatorcontrib><creatorcontrib>Sundet, Kjetil</creatorcontrib><creatorcontrib>Andreassen, Ole A</creatorcontrib><creatorcontrib>Rund, Bjørn Rishovd</creatorcontrib><creatorcontrib>Melle, Ingrid</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Schizophrenia research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Holmén, Aina</au><au>Juuhl-Langseth, Monica</au><au>Thormodsen, Rune</au><au>Ueland, Torill</au><au>Agartz, Ingrid</au><au>Sundet, Kjetil</au><au>Andreassen, Ole A</au><au>Rund, Bjørn Rishovd</au><au>Melle, Ingrid</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Executive function in early- and adult onset schizophrenia</atitle><jtitle>Schizophrenia research</jtitle><addtitle>Schizophr Res</addtitle><date>2012-12-01</date><risdate>2012</risdate><volume>142</volume><issue>1</issue><spage>177</spage><epage>182</epage><pages>177-182</pages><issn>0920-9964</issn><eissn>1573-2509</eissn><abstract>Abstract Background The goal of this study was to investigate differences in executive functioning between patients with early-onset and adult-onset schizophrenia spectrum psychoses at the time of first treatment. Methods Neuropsychological tests covering executive functioning domains were performed for 20 adolescents with early-onset schizophrenia (EOS) close to first treatment and 90 first episode patients with adult onset schizophrenia (AOS) in addition to 66 adolescent- and 127 adult age and gender matched healthy controls. Results Both EOS and AOS patients had significantly poorer executive performance than their age- and gender matched healthy counterparts. Both healthy adolescent controls and EOS patients had poorer executive performance than their adult counterparts. However, there were no differences in executive functioning between EOS and AOS patients after controlling for the levels of their age matched healthy control groups. Substituting EOS/AOS status with other age-at-onset thresholds had no effect. Conclusions We find the same relative levels of executive dysfunction in EOS- and AOS groups at the time of first treatment. This does not necessarily contradict previous findings of more severe dysfunction in EOS patients over time, but indicates an interaction between the disorder and the maturational processes that only can be investigated through longitudinal studies.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>23102692</pmid><doi>10.1016/j.schres.2012.10.006</doi><tpages>6</tpages></addata></record> |
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| subjects | Adolescent Adult Adult and adolescent clinical studies Age of Onset Aged Analysis of Variance Biological and medical sciences Child Cognition Disorders - diagnosis Cognition Disorders - etiology Early onset Executive Function - physiology Executive functioning Female First episode psychosis Humans Male Medical sciences Middle Aged Neurocognition Psychiatric Status Rating Scales Psychiatry Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychoses Schizophrenia Schizophrenia - complications Schizophrenic Psychology Young Adult |
| title | Executive function in early- and adult onset schizophrenia |
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