MTHFR C677T, A1298C and ACE I/D polymorphisms as risk factors for diabetic nephropathy among type 2 diabetic patients
Background: Genetic variations have been proposed to play a role in the susceptibility to diabetic nephropathy. Objectives: To check for the association of genetic polymorphisms of methylenetetrahydrofolate reductase (MTHFR) and angiotensin converting enzyme (ACE) genes with the development of diabe...
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| Veröffentlicht in: | Journal of the renin-angiotensin-aldosterone system 2012-12, Vol.13 (4), p.472-477 |
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| container_end_page | 477 |
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| container_issue | 4 |
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| container_title | Journal of the renin-angiotensin-aldosterone system |
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| creator | El-Baz, Rizk Settin, Ahmad Ismaeel, Azza Khaleel, Abd Allah Abbas, Tarek Tolba, Wafaa Abd Allah, Wafaa Sobh, Mohammed Abd El-Kader |
| description | Background:
Genetic variations have been proposed to play a role in the susceptibility to diabetic nephropathy.
Objectives:
To check for the association of genetic polymorphisms of methylenetetrahydrofolate reductase (MTHFR) and angiotensin converting enzyme (ACE) genes with the development of diabetic nephropathy among type 2 diabetic patients.
Methods:
Participants comprised 202 patients with type 2 diabetes, of whom 102 were affected with diabetic nephropathy. Genetic variants corresponding to MTHFR C677T, A1298C and ACE I/D genotypes were determined using the PCR technique coupled with digestion and restriction analysis.
Results:
Cases with diabetic nephropathy had a significantly higher frequency of the MTHFR 677 TT, 677 CT, ACE DD mutant genotypes compared with diabetic cases without nephropathy. Analysis of the association of studied MTHFR C677T, A1298C and ACE I/D polymorphisms with albuminuria showed that the MTHFR 677 T polymorphism, in the recessive and dominant models, was a risk factor for both micro and macroalbuminuria, while the ACE DD mutant genotype was a risk factor for microalbuminuria and the MTHFR 1298C in the dominant model only was a risk factor for macroalbuminuria.
Conclusion:
These findings indicate that ACE and MTHFR genetic polymorphisms might be considered as genetic risk factors for diabetic nephropathy among patients with type 2 diabetes. |
| doi_str_mv | 10.1177/1470320312444651 |
| format | Article |
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Genetic variations have been proposed to play a role in the susceptibility to diabetic nephropathy.
Objectives:
To check for the association of genetic polymorphisms of methylenetetrahydrofolate reductase (MTHFR) and angiotensin converting enzyme (ACE) genes with the development of diabetic nephropathy among type 2 diabetic patients.
Methods:
Participants comprised 202 patients with type 2 diabetes, of whom 102 were affected with diabetic nephropathy. Genetic variants corresponding to MTHFR C677T, A1298C and ACE I/D genotypes were determined using the PCR technique coupled with digestion and restriction analysis.
Results:
Cases with diabetic nephropathy had a significantly higher frequency of the MTHFR 677 TT, 677 CT, ACE DD mutant genotypes compared with diabetic cases without nephropathy. Analysis of the association of studied MTHFR C677T, A1298C and ACE I/D polymorphisms with albuminuria showed that the MTHFR 677 T polymorphism, in the recessive and dominant models, was a risk factor for both micro and macroalbuminuria, while the ACE DD mutant genotype was a risk factor for microalbuminuria and the MTHFR 1298C in the dominant model only was a risk factor for macroalbuminuria.
Conclusion:
These findings indicate that ACE and MTHFR genetic polymorphisms might be considered as genetic risk factors for diabetic nephropathy among patients with type 2 diabetes.</description><identifier>ISSN: 1470-3203</identifier><identifier>EISSN: 1752-8976</identifier><identifier>DOI: 10.1177/1470320312444651</identifier><identifier>PMID: 22554825</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Albuminuria - complications ; Albuminuria - genetics ; Alleles ; Case-Control Studies ; Diabetes Mellitus, Type 2 - complications ; Diabetes Mellitus, Type 2 - enzymology ; Diabetes Mellitus, Type 2 - genetics ; Diabetic Nephropathies - complications ; Diabetic Nephropathies - enzymology ; Diabetic Nephropathies - genetics ; Female ; Genetic Predisposition to Disease ; Haplotypes - genetics ; Humans ; INDEL Mutation - genetics ; Male ; Methylenetetrahydrofolate Reductase (NADPH2) - genetics ; Middle Aged ; Peptidyl-Dipeptidase A - genetics ; Polymorphism, Single Nucleotide - genetics ; Risk Factors</subject><ispartof>Journal of the renin-angiotensin-aldosterone system, 2012-12, Vol.13 (4), p.472-477</ispartof><rights>The Author(s) 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c379t-f296be7bd6706e2c4671a55651aaa1eaf9711fb95628ffc4895a345c5aff0bc73</citedby><cites>FETCH-LOGICAL-c379t-f296be7bd6706e2c4671a55651aaa1eaf9711fb95628ffc4895a345c5aff0bc73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27929,27930</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22554825$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>El-Baz, Rizk</creatorcontrib><creatorcontrib>Settin, Ahmad</creatorcontrib><creatorcontrib>Ismaeel, Azza</creatorcontrib><creatorcontrib>Khaleel, Abd Allah</creatorcontrib><creatorcontrib>Abbas, Tarek</creatorcontrib><creatorcontrib>Tolba, Wafaa</creatorcontrib><creatorcontrib>Abd Allah, Wafaa</creatorcontrib><creatorcontrib>Sobh, Mohammed Abd El-Kader</creatorcontrib><title>MTHFR C677T, A1298C and ACE I/D polymorphisms as risk factors for diabetic nephropathy among type 2 diabetic patients</title><title>Journal of the renin-angiotensin-aldosterone system</title><addtitle>J Renin Angiotensin Aldosterone Syst</addtitle><description>Background:
Genetic variations have been proposed to play a role in the susceptibility to diabetic nephropathy.
Objectives:
To check for the association of genetic polymorphisms of methylenetetrahydrofolate reductase (MTHFR) and angiotensin converting enzyme (ACE) genes with the development of diabetic nephropathy among type 2 diabetic patients.
Methods:
Participants comprised 202 patients with type 2 diabetes, of whom 102 were affected with diabetic nephropathy. Genetic variants corresponding to MTHFR C677T, A1298C and ACE I/D genotypes were determined using the PCR technique coupled with digestion and restriction analysis.
Results:
Cases with diabetic nephropathy had a significantly higher frequency of the MTHFR 677 TT, 677 CT, ACE DD mutant genotypes compared with diabetic cases without nephropathy. Analysis of the association of studied MTHFR C677T, A1298C and ACE I/D polymorphisms with albuminuria showed that the MTHFR 677 T polymorphism, in the recessive and dominant models, was a risk factor for both micro and macroalbuminuria, while the ACE DD mutant genotype was a risk factor for microalbuminuria and the MTHFR 1298C in the dominant model only was a risk factor for macroalbuminuria.
Conclusion:
These findings indicate that ACE and MTHFR genetic polymorphisms might be considered as genetic risk factors for diabetic nephropathy among patients with type 2 diabetes.</description><subject>Albuminuria - complications</subject><subject>Albuminuria - genetics</subject><subject>Alleles</subject><subject>Case-Control Studies</subject><subject>Diabetes Mellitus, Type 2 - complications</subject><subject>Diabetes Mellitus, Type 2 - enzymology</subject><subject>Diabetes Mellitus, Type 2 - genetics</subject><subject>Diabetic Nephropathies - complications</subject><subject>Diabetic Nephropathies - enzymology</subject><subject>Diabetic Nephropathies - genetics</subject><subject>Female</subject><subject>Genetic Predisposition to Disease</subject><subject>Haplotypes - genetics</subject><subject>Humans</subject><subject>INDEL Mutation - genetics</subject><subject>Male</subject><subject>Methylenetetrahydrofolate Reductase (NADPH2) - genetics</subject><subject>Middle Aged</subject><subject>Peptidyl-Dipeptidase A - genetics</subject><subject>Polymorphism, Single Nucleotide - genetics</subject><subject>Risk Factors</subject><issn>1470-3203</issn><issn>1752-8976</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kMFLwzAYxYMoOqd3T5KjB6tJmjTNcdRNhYkg81y-Zomrrk1N2sP-ezM2FQRP3wfv9x68h9AFJTeUSnlLuSQpIyllnPNM0AM0olKwJFcyO4x_lJOtfoJOQ3gnJM05Z8fohDEheM7ECA1Pi4fZCy4yKRfXeEKZygsM7RJPiil-vL3DnVtvGue7VR2agCFgX4cPbEH3zgdsncfLGirT1xq3plt510G_2mBoXPuG-01nMPslolabtg9n6MjCOpjz_R2j19l0UTwk8-f7x2IyT3QqVZ9YprLKyGqZSZIZpnkmKQgRiwIANWCVpNRWSmQst1bzXAlIudACrCWVlukYXe1yO-8-BxP6sqmDNus1tMYNoYwjKq6EECSiZIdq70Lwxpadrxvwm5KSLSfLv2NHy-U-fagas_wxfK8bgWQHBHgz5bsbfBvb_h_4BSnRhHk</recordid><startdate>201212</startdate><enddate>201212</enddate><creator>El-Baz, Rizk</creator><creator>Settin, Ahmad</creator><creator>Ismaeel, Azza</creator><creator>Khaleel, Abd Allah</creator><creator>Abbas, Tarek</creator><creator>Tolba, Wafaa</creator><creator>Abd Allah, Wafaa</creator><creator>Sobh, Mohammed Abd El-Kader</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201212</creationdate><title>MTHFR C677T, A1298C and ACE I/D polymorphisms as risk factors for diabetic nephropathy among type 2 diabetic patients</title><author>El-Baz, Rizk ; Settin, Ahmad ; Ismaeel, Azza ; Khaleel, Abd Allah ; Abbas, Tarek ; Tolba, Wafaa ; Abd Allah, Wafaa ; Sobh, Mohammed Abd El-Kader</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c379t-f296be7bd6706e2c4671a55651aaa1eaf9711fb95628ffc4895a345c5aff0bc73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Albuminuria - complications</topic><topic>Albuminuria - genetics</topic><topic>Alleles</topic><topic>Case-Control Studies</topic><topic>Diabetes Mellitus, Type 2 - complications</topic><topic>Diabetes Mellitus, Type 2 - enzymology</topic><topic>Diabetes Mellitus, Type 2 - genetics</topic><topic>Diabetic Nephropathies - complications</topic><topic>Diabetic Nephropathies - enzymology</topic><topic>Diabetic Nephropathies - genetics</topic><topic>Female</topic><topic>Genetic Predisposition to Disease</topic><topic>Haplotypes - genetics</topic><topic>Humans</topic><topic>INDEL Mutation - genetics</topic><topic>Male</topic><topic>Methylenetetrahydrofolate Reductase (NADPH2) - genetics</topic><topic>Middle Aged</topic><topic>Peptidyl-Dipeptidase A - genetics</topic><topic>Polymorphism, Single Nucleotide - genetics</topic><topic>Risk Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>El-Baz, Rizk</creatorcontrib><creatorcontrib>Settin, Ahmad</creatorcontrib><creatorcontrib>Ismaeel, Azza</creatorcontrib><creatorcontrib>Khaleel, Abd Allah</creatorcontrib><creatorcontrib>Abbas, Tarek</creatorcontrib><creatorcontrib>Tolba, Wafaa</creatorcontrib><creatorcontrib>Abd Allah, Wafaa</creatorcontrib><creatorcontrib>Sobh, Mohammed Abd El-Kader</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the renin-angiotensin-aldosterone system</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>El-Baz, Rizk</au><au>Settin, Ahmad</au><au>Ismaeel, Azza</au><au>Khaleel, Abd Allah</au><au>Abbas, Tarek</au><au>Tolba, Wafaa</au><au>Abd Allah, Wafaa</au><au>Sobh, Mohammed Abd El-Kader</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>MTHFR C677T, A1298C and ACE I/D polymorphisms as risk factors for diabetic nephropathy among type 2 diabetic patients</atitle><jtitle>Journal of the renin-angiotensin-aldosterone system</jtitle><addtitle>J Renin Angiotensin Aldosterone Syst</addtitle><date>2012-12</date><risdate>2012</risdate><volume>13</volume><issue>4</issue><spage>472</spage><epage>477</epage><pages>472-477</pages><issn>1470-3203</issn><eissn>1752-8976</eissn><abstract>Background:
Genetic variations have been proposed to play a role in the susceptibility to diabetic nephropathy.
Objectives:
To check for the association of genetic polymorphisms of methylenetetrahydrofolate reductase (MTHFR) and angiotensin converting enzyme (ACE) genes with the development of diabetic nephropathy among type 2 diabetic patients.
Methods:
Participants comprised 202 patients with type 2 diabetes, of whom 102 were affected with diabetic nephropathy. Genetic variants corresponding to MTHFR C677T, A1298C and ACE I/D genotypes were determined using the PCR technique coupled with digestion and restriction analysis.
Results:
Cases with diabetic nephropathy had a significantly higher frequency of the MTHFR 677 TT, 677 CT, ACE DD mutant genotypes compared with diabetic cases without nephropathy. Analysis of the association of studied MTHFR C677T, A1298C and ACE I/D polymorphisms with albuminuria showed that the MTHFR 677 T polymorphism, in the recessive and dominant models, was a risk factor for both micro and macroalbuminuria, while the ACE DD mutant genotype was a risk factor for microalbuminuria and the MTHFR 1298C in the dominant model only was a risk factor for macroalbuminuria.
Conclusion:
These findings indicate that ACE and MTHFR genetic polymorphisms might be considered as genetic risk factors for diabetic nephropathy among patients with type 2 diabetes.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>22554825</pmid><doi>10.1177/1470320312444651</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Albuminuria - complications Albuminuria - genetics Alleles Case-Control Studies Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - enzymology Diabetes Mellitus, Type 2 - genetics Diabetic Nephropathies - complications Diabetic Nephropathies - enzymology Diabetic Nephropathies - genetics Female Genetic Predisposition to Disease Haplotypes - genetics Humans INDEL Mutation - genetics Male Methylenetetrahydrofolate Reductase (NADPH2) - genetics Middle Aged Peptidyl-Dipeptidase A - genetics Polymorphism, Single Nucleotide - genetics Risk Factors |
| title | MTHFR C677T, A1298C and ACE I/D polymorphisms as risk factors for diabetic nephropathy among type 2 diabetic patients |
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