Quality of life in childhood immune thrombocytopenia: International validation of the kids' ITP tools
Background The Kids ITP Tools (KIT) is a disease‐specific measure of health‐related quality of life for children with immune thrombocytopenia (ITP). To facilitate use in international trials it has been cross‐culturally adapted for France, Germany, the United Kingdom and Uruguay. This study assessed...
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| Veröffentlicht in: | Pediatric blood & cancer 2013-01, Vol.60 (1), p.95-100 |
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| creator | Klaassen, Robert J. Blanchette, Victor Burke, Tricia A. Wakefield, Cindy Grainger, John D. Gaedicke, Gerhard Riedlinger, Arne Dufort, Gustavo Citrin, Estela Reguerre, Yves Pellier, Isabelle Curtis, Christine Young, Nancy L. |
| description | Background
The Kids ITP Tools (KIT) is a disease‐specific measure of health‐related quality of life for children with immune thrombocytopenia (ITP). To facilitate use in international trials it has been cross‐culturally adapted for France, Germany, the United Kingdom and Uruguay. This study assessed the validity and reliability of the translated KIT in comparison to generic quality of life measures.
Methods
Children 2–18 years of age with ITP and their parents were recruited in France, Germany, the United Kingdom and Uruguay. Participants completed the KIT, PedsQL and KINDL. We examined the Pearson's correlation between these measures for our pooled sample and estimated the reliability over a 2‐week time period. Findings were further explored by country.
Results
A total of 127 families (81 children self‐reported) participated. Mean child‐reported scores were: KIT 74.3 (SD = 15.3), PedsQL 81.3 (SD = 13.0), and KINDL 70.5 (SD = 14.3). Corresponding mean parent proxy‐reported scores were: 70.6 (SD = 18.1), 75.7 (SD = 16.8) and 72.3 (SD = 12.7), respectively. Correlation between KIT and the generic measures was consistent with our a priori hypothesis (PedsQL r = 0.54, KINDL r = 0.48, both P |
| doi_str_mv | 10.1002/pbc.24257 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1179494751</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2825436571</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3917-1750994088bcbd2980aa492020aa26d869e70a68ee680581260e0204fa20ae383</originalsourceid><addsrcrecordid>eNp1kMFO3DAURS1EVSh00R-oLLGgXQRsx4ltdjAqMNIIqDSFpeUkLxqDEw-xQzt_X8PALJBYPVvvvCPdi9A3So4oIex4WdVHjLNCbKFdWvAiKwgV25s3UTvoSwj3CS1JIT-jHcYkl4STXQS_R-NsXGHfYmdbwLbH9cK6ZuF9g23XjT3guBh8V_l6Ff0SemtO8LSPMPQmWt8bh5-Sonn5PGviAvCDbcIhns5vcPTehX30qTUuwNfXuYf-nP-aTy6z2fXFdHI6y-pcUZFRURClOJGyqquGKUmM4YoRliYrG1kqEMSUEqCUKQhNcSAteWsSAbnM99CPtXc5-McRQtSdDTU4Z3rwY9CUCsUVFwVN6ME79N6PKZJLFCMyz7nISaJ-rql68CEM0OrlYDszrDQl-rl7nbrXL90n9vurcaw6aDbkW9kJOF4Df62D1ccmfXM2eVNm6wsbIvzbXJjhQZciF4W-u7rQ8_NLdju7PdNX-X8qApsb</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1208334730</pqid></control><display><type>article</type><title>Quality of life in childhood immune thrombocytopenia: International validation of the kids' ITP tools</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Klaassen, Robert J. ; Blanchette, Victor ; Burke, Tricia A. ; Wakefield, Cindy ; Grainger, John D. ; Gaedicke, Gerhard ; Riedlinger, Arne ; Dufort, Gustavo ; Citrin, Estela ; Reguerre, Yves ; Pellier, Isabelle ; Curtis, Christine ; Young, Nancy L.</creator><creatorcontrib>Klaassen, Robert J. ; Blanchette, Victor ; Burke, Tricia A. ; Wakefield, Cindy ; Grainger, John D. ; Gaedicke, Gerhard ; Riedlinger, Arne ; Dufort, Gustavo ; Citrin, Estela ; Reguerre, Yves ; Pellier, Isabelle ; Curtis, Christine ; Young, Nancy L.</creatorcontrib><description>Background
The Kids ITP Tools (KIT) is a disease‐specific measure of health‐related quality of life for children with immune thrombocytopenia (ITP). To facilitate use in international trials it has been cross‐culturally adapted for France, Germany, the United Kingdom and Uruguay. This study assessed the validity and reliability of the translated KIT in comparison to generic quality of life measures.
Methods
Children 2–18 years of age with ITP and their parents were recruited in France, Germany, the United Kingdom and Uruguay. Participants completed the KIT, PedsQL and KINDL. We examined the Pearson's correlation between these measures for our pooled sample and estimated the reliability over a 2‐week time period. Findings were further explored by country.
Results
A total of 127 families (81 children self‐reported) participated. Mean child‐reported scores were: KIT 74.3 (SD = 15.3), PedsQL 81.3 (SD = 13.0), and KINDL 70.5 (SD = 14.3). Corresponding mean parent proxy‐reported scores were: 70.6 (SD = 18.1), 75.7 (SD = 16.8) and 72.3 (SD = 12.7), respectively. Correlation between KIT and the generic measures was consistent with our a priori hypothesis (PedsQL r = 0.54, KINDL r = 0.48, both P < 0.0001). Child KIT scores for newly diagnosed ITP patients were significantly lower than for chronic ITP patients (67.3 vs. 77.3; P = 0.005). There was a significant correlation (P < 0.001) between the child and parent proxy KIT scores (ICC = 0.52). Child KIT test‐retest reliability was acceptable at 0.71.
Conclusions
The cross‐culturally translated KIT is valid and reliable with acceptable correlation to the PedsQL and KINDL. There is a significant difference in child self‐reported KIT scores between newly diagnosed and chronic ITP. Pediatr Blood Cancer 2013; 60: 95–100. © 2012 Wiley Periodicals, Inc.</description><identifier>ISSN: 1545-5009</identifier><identifier>EISSN: 1545-5017</identifier><identifier>DOI: 10.1002/pbc.24257</identifier><identifier>PMID: 22848040</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adolescent ; Child ; Child, Preschool ; comparative study ; Hematology ; Humans ; idiopathic ; multicenter study ; Oncology ; parents ; Pediatrics ; purpura ; Purpura, Thrombocytopenic, Idiopathic - psychology ; Quality of Life ; questionnaires ; Reproducibility of Results ; thrombocytopenic</subject><ispartof>Pediatric blood & cancer, 2013-01, Vol.60 (1), p.95-100</ispartof><rights>Copyright © 2012 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3917-1750994088bcbd2980aa492020aa26d869e70a68ee680581260e0204fa20ae383</citedby><cites>FETCH-LOGICAL-c3917-1750994088bcbd2980aa492020aa26d869e70a68ee680581260e0204fa20ae383</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fpbc.24257$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fpbc.24257$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22848040$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Klaassen, Robert J.</creatorcontrib><creatorcontrib>Blanchette, Victor</creatorcontrib><creatorcontrib>Burke, Tricia A.</creatorcontrib><creatorcontrib>Wakefield, Cindy</creatorcontrib><creatorcontrib>Grainger, John D.</creatorcontrib><creatorcontrib>Gaedicke, Gerhard</creatorcontrib><creatorcontrib>Riedlinger, Arne</creatorcontrib><creatorcontrib>Dufort, Gustavo</creatorcontrib><creatorcontrib>Citrin, Estela</creatorcontrib><creatorcontrib>Reguerre, Yves</creatorcontrib><creatorcontrib>Pellier, Isabelle</creatorcontrib><creatorcontrib>Curtis, Christine</creatorcontrib><creatorcontrib>Young, Nancy L.</creatorcontrib><title>Quality of life in childhood immune thrombocytopenia: International validation of the kids' ITP tools</title><title>Pediatric blood & cancer</title><addtitle>Pediatr. Blood Cancer</addtitle><description>Background
The Kids ITP Tools (KIT) is a disease‐specific measure of health‐related quality of life for children with immune thrombocytopenia (ITP). To facilitate use in international trials it has been cross‐culturally adapted for France, Germany, the United Kingdom and Uruguay. This study assessed the validity and reliability of the translated KIT in comparison to generic quality of life measures.
Methods
Children 2–18 years of age with ITP and their parents were recruited in France, Germany, the United Kingdom and Uruguay. Participants completed the KIT, PedsQL and KINDL. We examined the Pearson's correlation between these measures for our pooled sample and estimated the reliability over a 2‐week time period. Findings were further explored by country.
Results
A total of 127 families (81 children self‐reported) participated. Mean child‐reported scores were: KIT 74.3 (SD = 15.3), PedsQL 81.3 (SD = 13.0), and KINDL 70.5 (SD = 14.3). Corresponding mean parent proxy‐reported scores were: 70.6 (SD = 18.1), 75.7 (SD = 16.8) and 72.3 (SD = 12.7), respectively. Correlation between KIT and the generic measures was consistent with our a priori hypothesis (PedsQL r = 0.54, KINDL r = 0.48, both P < 0.0001). Child KIT scores for newly diagnosed ITP patients were significantly lower than for chronic ITP patients (67.3 vs. 77.3; P = 0.005). There was a significant correlation (P < 0.001) between the child and parent proxy KIT scores (ICC = 0.52). Child KIT test‐retest reliability was acceptable at 0.71.
Conclusions
The cross‐culturally translated KIT is valid and reliable with acceptable correlation to the PedsQL and KINDL. There is a significant difference in child self‐reported KIT scores between newly diagnosed and chronic ITP. Pediatr Blood Cancer 2013; 60: 95–100. © 2012 Wiley Periodicals, Inc.</description><subject>Adolescent</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>comparative study</subject><subject>Hematology</subject><subject>Humans</subject><subject>idiopathic</subject><subject>multicenter study</subject><subject>Oncology</subject><subject>parents</subject><subject>Pediatrics</subject><subject>purpura</subject><subject>Purpura, Thrombocytopenic, Idiopathic - psychology</subject><subject>Quality of Life</subject><subject>questionnaires</subject><subject>Reproducibility of Results</subject><subject>thrombocytopenic</subject><issn>1545-5009</issn><issn>1545-5017</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kMFO3DAURS1EVSh00R-oLLGgXQRsx4ltdjAqMNIIqDSFpeUkLxqDEw-xQzt_X8PALJBYPVvvvCPdi9A3So4oIex4WdVHjLNCbKFdWvAiKwgV25s3UTvoSwj3CS1JIT-jHcYkl4STXQS_R-NsXGHfYmdbwLbH9cK6ZuF9g23XjT3guBh8V_l6Ff0SemtO8LSPMPQmWt8bh5-Sonn5PGviAvCDbcIhns5vcPTehX30qTUuwNfXuYf-nP-aTy6z2fXFdHI6y-pcUZFRURClOJGyqquGKUmM4YoRliYrG1kqEMSUEqCUKQhNcSAteWsSAbnM99CPtXc5-McRQtSdDTU4Z3rwY9CUCsUVFwVN6ME79N6PKZJLFCMyz7nISaJ-rql68CEM0OrlYDszrDQl-rl7nbrXL90n9vurcaw6aDbkW9kJOF4Df62D1ccmfXM2eVNm6wsbIvzbXJjhQZciF4W-u7rQ8_NLdju7PdNX-X8qApsb</recordid><startdate>201301</startdate><enddate>201301</enddate><creator>Klaassen, Robert J.</creator><creator>Blanchette, Victor</creator><creator>Burke, Tricia A.</creator><creator>Wakefield, Cindy</creator><creator>Grainger, John D.</creator><creator>Gaedicke, Gerhard</creator><creator>Riedlinger, Arne</creator><creator>Dufort, Gustavo</creator><creator>Citrin, Estela</creator><creator>Reguerre, Yves</creator><creator>Pellier, Isabelle</creator><creator>Curtis, Christine</creator><creator>Young, Nancy L.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>7TO</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>201301</creationdate><title>Quality of life in childhood immune thrombocytopenia: International validation of the kids' ITP tools</title><author>Klaassen, Robert J. ; Blanchette, Victor ; Burke, Tricia A. ; Wakefield, Cindy ; Grainger, John D. ; Gaedicke, Gerhard ; Riedlinger, Arne ; Dufort, Gustavo ; Citrin, Estela ; Reguerre, Yves ; Pellier, Isabelle ; Curtis, Christine ; Young, Nancy L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3917-1750994088bcbd2980aa492020aa26d869e70a68ee680581260e0204fa20ae383</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adolescent</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>comparative study</topic><topic>Hematology</topic><topic>Humans</topic><topic>idiopathic</topic><topic>multicenter study</topic><topic>Oncology</topic><topic>parents</topic><topic>Pediatrics</topic><topic>purpura</topic><topic>Purpura, Thrombocytopenic, Idiopathic - psychology</topic><topic>Quality of Life</topic><topic>questionnaires</topic><topic>Reproducibility of Results</topic><topic>thrombocytopenic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Klaassen, Robert J.</creatorcontrib><creatorcontrib>Blanchette, Victor</creatorcontrib><creatorcontrib>Burke, Tricia A.</creatorcontrib><creatorcontrib>Wakefield, Cindy</creatorcontrib><creatorcontrib>Grainger, John D.</creatorcontrib><creatorcontrib>Gaedicke, Gerhard</creatorcontrib><creatorcontrib>Riedlinger, Arne</creatorcontrib><creatorcontrib>Dufort, Gustavo</creatorcontrib><creatorcontrib>Citrin, Estela</creatorcontrib><creatorcontrib>Reguerre, Yves</creatorcontrib><creatorcontrib>Pellier, Isabelle</creatorcontrib><creatorcontrib>Curtis, Christine</creatorcontrib><creatorcontrib>Young, Nancy L.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatric blood & cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Klaassen, Robert J.</au><au>Blanchette, Victor</au><au>Burke, Tricia A.</au><au>Wakefield, Cindy</au><au>Grainger, John D.</au><au>Gaedicke, Gerhard</au><au>Riedlinger, Arne</au><au>Dufort, Gustavo</au><au>Citrin, Estela</au><au>Reguerre, Yves</au><au>Pellier, Isabelle</au><au>Curtis, Christine</au><au>Young, Nancy L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Quality of life in childhood immune thrombocytopenia: International validation of the kids' ITP tools</atitle><jtitle>Pediatric blood & cancer</jtitle><addtitle>Pediatr. Blood Cancer</addtitle><date>2013-01</date><risdate>2013</risdate><volume>60</volume><issue>1</issue><spage>95</spage><epage>100</epage><pages>95-100</pages><issn>1545-5009</issn><eissn>1545-5017</eissn><abstract>Background
The Kids ITP Tools (KIT) is a disease‐specific measure of health‐related quality of life for children with immune thrombocytopenia (ITP). To facilitate use in international trials it has been cross‐culturally adapted for France, Germany, the United Kingdom and Uruguay. This study assessed the validity and reliability of the translated KIT in comparison to generic quality of life measures.
Methods
Children 2–18 years of age with ITP and their parents were recruited in France, Germany, the United Kingdom and Uruguay. Participants completed the KIT, PedsQL and KINDL. We examined the Pearson's correlation between these measures for our pooled sample and estimated the reliability over a 2‐week time period. Findings were further explored by country.
Results
A total of 127 families (81 children self‐reported) participated. Mean child‐reported scores were: KIT 74.3 (SD = 15.3), PedsQL 81.3 (SD = 13.0), and KINDL 70.5 (SD = 14.3). Corresponding mean parent proxy‐reported scores were: 70.6 (SD = 18.1), 75.7 (SD = 16.8) and 72.3 (SD = 12.7), respectively. Correlation between KIT and the generic measures was consistent with our a priori hypothesis (PedsQL r = 0.54, KINDL r = 0.48, both P < 0.0001). Child KIT scores for newly diagnosed ITP patients were significantly lower than for chronic ITP patients (67.3 vs. 77.3; P = 0.005). There was a significant correlation (P < 0.001) between the child and parent proxy KIT scores (ICC = 0.52). Child KIT test‐retest reliability was acceptable at 0.71.
Conclusions
The cross‐culturally translated KIT is valid and reliable with acceptable correlation to the PedsQL and KINDL. There is a significant difference in child self‐reported KIT scores between newly diagnosed and chronic ITP. Pediatr Blood Cancer 2013; 60: 95–100. © 2012 Wiley Periodicals, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>22848040</pmid><doi>10.1002/pbc.24257</doi><tpages>6</tpages></addata></record> |
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| subjects | Adolescent Child Child, Preschool comparative study Hematology Humans idiopathic multicenter study Oncology parents Pediatrics purpura Purpura, Thrombocytopenic, Idiopathic - psychology Quality of Life questionnaires Reproducibility of Results thrombocytopenic |
| title | Quality of life in childhood immune thrombocytopenia: International validation of the kids' ITP tools |
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