Ezetimibe inhibits PMA-induced monocyte/macrophage differentiation by altering microRNA expression: A novel anti-atherosclerotic mechanism

Ezetimibe, a selective inhibitor of intestinal cholesterol absorption, effectively reduces plasma cholesterol both in monotherapy or combined with a statin. However, its effect on atherosclerosis plaque progression is certainly unknown. MicroRNAs are short non-encoding RNA molecules dynamically impl...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Pharmacological research 2012-12, Vol.66 (6), p.536-543
Hauptverfasser:	Muñoz-Pacheco, Paloma, Ortega-Hernández, Adriana, Miana, María, Cachofeiro, Victoria, Fernández-Cruz, Arturo, Gómez-Garre, Dulcenombre
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticholesteremic Agents - pharmacology Atherosclerosis - prevention & control Azetidines - pharmacology Cell Adhesion - drug effects Cell Culture Techniques Cell Differentiation - drug effects Cell Line Differentiation Ezetimibe Flow Cytometry Humans Macrophages - cytology Macrophages - drug effects Macrophages - metabolism MicroRNAs MicroRNAs - biosynthesis Monocyte/macrophage Monocytes - cytology Monocytes - drug effects Monocytes - metabolism NF-kappa B - metabolism Reactive Oxygen Species - metabolism Real-Time Polymerase Chain Reaction Tetradecanoylphorbol Acetate - analogs & derivatives Tetradecanoylphorbol Acetate - pharmacology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!