Nesfatin-1 in newborns: relationship with endocrine and metabolic and anthropometric measures
To explore the relationship between nesfatin-1 and growth and development in newborns. Blood samples for nesfatin-1, ghrelin, insulin-like growth factor-1 (IGF-1), insulin and glucose were obtained from preterm (n=53) and term infants (n=60), including appropriate for gestational age (AGA) (n=32) an...
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| Veröffentlicht in: | Journal of Pediatric Endocrinology and Metabolism 2012-08, Vol.25 (7), p.727-732 |
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| container_title | Journal of Pediatric Endocrinology and Metabolism |
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| creator | Cheng, Ya-Ying Zhao, Xiu-Mian Cai, Bao-Ping Ma, Li-Na Yin, Jian-Ying Song, Guang-Yao |
| description | To explore the relationship between nesfatin-1 and growth and development in newborns.
Blood samples for nesfatin-1, ghrelin, insulin-like growth factor-1 (IGF-1), insulin and glucose were obtained from preterm (n=53) and term infants (n=60), including appropriate for gestational age (AGA) (n=32) and small for gestational age (SGA) infants (n=28). The relationship between nesfatin-1 and other metabolic hormones or anthropometric parameters was evaluated.
The concentrations of nesfatin-1, ghrelin and insulin and the homeostasis model assessment-insulin resistance index (HOMA-IR) were higher in SGA than AGA infants (p=0.0358, 0.0163, 0.0001 and 0.0051, respectively), but IGF-1 levels and homeostasis model assessment-insulin sensitivity index (HOMA-ISI) were lower (p=0.033 and 0.0001, respectively). Nesfatin-1 levels in SGA infants were higher on postnatal day 0 (PND0) than in AGA infants (p=0.0358) and lower on PND7 (p=0.0002) and PND28 (p=0.0488). A negative correlation showed between nesfatin-1 and oral calorie intake (r=–0.446; p=0.017) and HOMA-ISI (r=–0.398; p=0.036), and a positive correlation between nesfatin-1 and HOMA-IR (r=0.43; p=0.023) in SGA infants.
Nesfatin-1 is involved in the physiological regulation of intrauterine and postnatal growth and development in SGA infants. |
| doi_str_mv | 10.1515/jpem-2012-0095 |
| format | Article |
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Blood samples for nesfatin-1, ghrelin, insulin-like growth factor-1 (IGF-1), insulin and glucose were obtained from preterm (n=53) and term infants (n=60), including appropriate for gestational age (AGA) (n=32) and small for gestational age (SGA) infants (n=28). The relationship between nesfatin-1 and other metabolic hormones or anthropometric parameters was evaluated.
The concentrations of nesfatin-1, ghrelin and insulin and the homeostasis model assessment-insulin resistance index (HOMA-IR) were higher in SGA than AGA infants (p=0.0358, 0.0163, 0.0001 and 0.0051, respectively), but IGF-1 levels and homeostasis model assessment-insulin sensitivity index (HOMA-ISI) were lower (p=0.033 and 0.0001, respectively). Nesfatin-1 levels in SGA infants were higher on postnatal day 0 (PND0) than in AGA infants (p=0.0358) and lower on PND7 (p=0.0002) and PND28 (p=0.0488). A negative correlation showed between nesfatin-1 and oral calorie intake (r=–0.446; p=0.017) and HOMA-ISI (r=–0.398; p=0.036), and a positive correlation between nesfatin-1 and HOMA-IR (r=0.43; p=0.023) in SGA infants.
Nesfatin-1 is involved in the physiological regulation of intrauterine and postnatal growth and development in SGA infants.</description><identifier>ISSN: 0334-018X</identifier><identifier>EISSN: 2191-0251</identifier><identifier>DOI: 10.1515/jpem-2012-0095</identifier><identifier>PMID: 23155701</identifier><language>eng</language><publisher>Germany: De Gruyter</publisher><subject>Anthropometry ; Body Weights and Measures ; Calcium-Binding Proteins - blood ; Calcium-Binding Proteins - metabolism ; Calcium-Binding Proteins - physiology ; Child Development - physiology ; Cohort Studies ; DNA-Binding Proteins - blood ; DNA-Binding Proteins - metabolism ; DNA-Binding Proteins - physiology ; Endocrine System - metabolism ; Endocrine System - physiology ; energy homeostasis ; Female ; Gestational Age ; growth and development ; Humans ; Infant, Newborn - blood ; Infant, Newborn - growth & development ; Infant, Newborn - metabolism ; Infant, Premature - blood ; Infant, Premature - growth & development ; Infant, Premature - metabolism ; Infant, Premature - physiology ; Infant, Small for Gestational Age - blood ; Infant, Small for Gestational Age - growth & development ; Infant, Small for Gestational Age - metabolism ; Infant, Small for Gestational Age - physiology ; Male ; Metabolism - physiology ; Nerve Tissue Proteins - blood ; Nerve Tissue Proteins - metabolism ; Nerve Tissue Proteins - physiology ; nesfatin-1 ; newborn ; Term Birth - blood ; Term Birth - metabolism ; Term Birth - physiology</subject><ispartof>Journal of Pediatric Endocrinology and Metabolism, 2012-08, Vol.25 (7), p.727-732</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c350t-9893332cee9e5b1ea6e44a685695811070b332ed16e0d90cde221a19425afcd3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.degruyter.com/document/doi/10.1515/jpem-2012-0095/pdf$$EPDF$$P50$$Gwalterdegruyter$$H</linktopdf><linktohtml>$$Uhttps://www.degruyter.com/document/doi/10.1515/jpem-2012-0095/html$$EHTML$$P50$$Gwalterdegruyter$$H</linktohtml><link.rule.ids>315,781,785,27929,27930,66759,68543</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23155701$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cheng, Ya-Ying</creatorcontrib><creatorcontrib>Zhao, Xiu-Mian</creatorcontrib><creatorcontrib>Cai, Bao-Ping</creatorcontrib><creatorcontrib>Ma, Li-Na</creatorcontrib><creatorcontrib>Yin, Jian-Ying</creatorcontrib><creatorcontrib>Song, Guang-Yao</creatorcontrib><title>Nesfatin-1 in newborns: relationship with endocrine and metabolic and anthropometric measures</title><title>Journal of Pediatric Endocrinology and Metabolism</title><addtitle>J Pediatr Endocrinol Metab</addtitle><description>To explore the relationship between nesfatin-1 and growth and development in newborns.
Blood samples for nesfatin-1, ghrelin, insulin-like growth factor-1 (IGF-1), insulin and glucose were obtained from preterm (n=53) and term infants (n=60), including appropriate for gestational age (AGA) (n=32) and small for gestational age (SGA) infants (n=28). The relationship between nesfatin-1 and other metabolic hormones or anthropometric parameters was evaluated.
The concentrations of nesfatin-1, ghrelin and insulin and the homeostasis model assessment-insulin resistance index (HOMA-IR) were higher in SGA than AGA infants (p=0.0358, 0.0163, 0.0001 and 0.0051, respectively), but IGF-1 levels and homeostasis model assessment-insulin sensitivity index (HOMA-ISI) were lower (p=0.033 and 0.0001, respectively). Nesfatin-1 levels in SGA infants were higher on postnatal day 0 (PND0) than in AGA infants (p=0.0358) and lower on PND7 (p=0.0002) and PND28 (p=0.0488). A negative correlation showed between nesfatin-1 and oral calorie intake (r=–0.446; p=0.017) and HOMA-ISI (r=–0.398; p=0.036), and a positive correlation between nesfatin-1 and HOMA-IR (r=0.43; p=0.023) in SGA infants.
Nesfatin-1 is involved in the physiological regulation of intrauterine and postnatal growth and development in SGA infants.</description><subject>Anthropometry</subject><subject>Body Weights and Measures</subject><subject>Calcium-Binding Proteins - blood</subject><subject>Calcium-Binding Proteins - metabolism</subject><subject>Calcium-Binding Proteins - physiology</subject><subject>Child Development - physiology</subject><subject>Cohort Studies</subject><subject>DNA-Binding Proteins - blood</subject><subject>DNA-Binding Proteins - metabolism</subject><subject>DNA-Binding Proteins - physiology</subject><subject>Endocrine System - metabolism</subject><subject>Endocrine System - physiology</subject><subject>energy homeostasis</subject><subject>Female</subject><subject>Gestational Age</subject><subject>growth and development</subject><subject>Humans</subject><subject>Infant, Newborn - blood</subject><subject>Infant, Newborn - growth & development</subject><subject>Infant, Newborn - metabolism</subject><subject>Infant, Premature - blood</subject><subject>Infant, Premature - growth & development</subject><subject>Infant, Premature - metabolism</subject><subject>Infant, Premature - physiology</subject><subject>Infant, Small for Gestational Age - blood</subject><subject>Infant, Small for Gestational Age - growth & development</subject><subject>Infant, Small for Gestational Age - metabolism</subject><subject>Infant, Small for Gestational Age - physiology</subject><subject>Male</subject><subject>Metabolism - physiology</subject><subject>Nerve Tissue Proteins - blood</subject><subject>Nerve Tissue Proteins - metabolism</subject><subject>Nerve Tissue Proteins - physiology</subject><subject>nesfatin-1</subject><subject>newborn</subject><subject>Term Birth - blood</subject><subject>Term Birth - metabolism</subject><subject>Term Birth - physiology</subject><issn>0334-018X</issn><issn>2191-0251</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kL1PwzAQxS0EgqqwMqKMLIE7u05iBiSE-JIqWBhYkOUkV5oqsYOdqOp_j0uBjenZz8_vdD_GThEuUKK8XPXUpRyQpwBK7rEJR4UpcIn7bAJCzFLA4u2InYSwAgAEFCjFITviUWUOOGHvzxQWZmhsikljE0vr0nkbrhJPbbSdDcumT9bNsEzI1q7yjaXE2DrpaDCla5vq-2bssPSud9H10erIhNFTOGYHC9MGOvnRKXu9v3u9fUznLw9PtzfztBIShlQVSgjBKyJFskQyGc1mJitkpmSBCDmU8ZlqzAhqBVVNnKNBNePSLKpaTNn5rrb37nOkMOiuCRW1rbHkxqAR8yJTvIhjpuxiF628C8HTQve-6YzfaAS9haq3UPUWqt5CjR_OfrrHsqP6L_6LMAaud4G1aQfyNX34cRMPeuVGb-PW_zRzmesi57n4AnL8h8I</recordid><startdate>20120801</startdate><enddate>20120801</enddate><creator>Cheng, Ya-Ying</creator><creator>Zhao, Xiu-Mian</creator><creator>Cai, Bao-Ping</creator><creator>Ma, Li-Na</creator><creator>Yin, Jian-Ying</creator><creator>Song, Guang-Yao</creator><general>De Gruyter</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20120801</creationdate><title>Nesfatin-1 in newborns: relationship with endocrine and metabolic and anthropometric measures</title><author>Cheng, Ya-Ying ; Zhao, Xiu-Mian ; Cai, Bao-Ping ; Ma, Li-Na ; Yin, Jian-Ying ; Song, Guang-Yao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c350t-9893332cee9e5b1ea6e44a685695811070b332ed16e0d90cde221a19425afcd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Anthropometry</topic><topic>Body Weights and Measures</topic><topic>Calcium-Binding Proteins - blood</topic><topic>Calcium-Binding Proteins - metabolism</topic><topic>Calcium-Binding Proteins - physiology</topic><topic>Child Development - physiology</topic><topic>Cohort Studies</topic><topic>DNA-Binding Proteins - blood</topic><topic>DNA-Binding Proteins - metabolism</topic><topic>DNA-Binding Proteins - physiology</topic><topic>Endocrine System - metabolism</topic><topic>Endocrine System - physiology</topic><topic>energy homeostasis</topic><topic>Female</topic><topic>Gestational Age</topic><topic>growth and development</topic><topic>Humans</topic><topic>Infant, Newborn - blood</topic><topic>Infant, Newborn - growth & development</topic><topic>Infant, Newborn - metabolism</topic><topic>Infant, Premature - blood</topic><topic>Infant, Premature - growth & development</topic><topic>Infant, Premature - metabolism</topic><topic>Infant, Premature - physiology</topic><topic>Infant, Small for Gestational Age - blood</topic><topic>Infant, Small for Gestational Age - growth & development</topic><topic>Infant, Small for Gestational Age - metabolism</topic><topic>Infant, Small for Gestational Age - physiology</topic><topic>Male</topic><topic>Metabolism - physiology</topic><topic>Nerve Tissue Proteins - blood</topic><topic>Nerve Tissue Proteins - metabolism</topic><topic>Nerve Tissue Proteins - physiology</topic><topic>nesfatin-1</topic><topic>newborn</topic><topic>Term Birth - blood</topic><topic>Term Birth - metabolism</topic><topic>Term Birth - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cheng, Ya-Ying</creatorcontrib><creatorcontrib>Zhao, Xiu-Mian</creatorcontrib><creatorcontrib>Cai, Bao-Ping</creatorcontrib><creatorcontrib>Ma, Li-Na</creatorcontrib><creatorcontrib>Yin, Jian-Ying</creatorcontrib><creatorcontrib>Song, Guang-Yao</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of Pediatric Endocrinology and Metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cheng, Ya-Ying</au><au>Zhao, Xiu-Mian</au><au>Cai, Bao-Ping</au><au>Ma, Li-Na</au><au>Yin, Jian-Ying</au><au>Song, Guang-Yao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nesfatin-1 in newborns: relationship with endocrine and metabolic and anthropometric measures</atitle><jtitle>Journal of Pediatric Endocrinology and Metabolism</jtitle><addtitle>J Pediatr Endocrinol Metab</addtitle><date>2012-08-01</date><risdate>2012</risdate><volume>25</volume><issue>7</issue><spage>727</spage><epage>732</epage><pages>727-732</pages><issn>0334-018X</issn><eissn>2191-0251</eissn><abstract>To explore the relationship between nesfatin-1 and growth and development in newborns.
Blood samples for nesfatin-1, ghrelin, insulin-like growth factor-1 (IGF-1), insulin and glucose were obtained from preterm (n=53) and term infants (n=60), including appropriate for gestational age (AGA) (n=32) and small for gestational age (SGA) infants (n=28). The relationship between nesfatin-1 and other metabolic hormones or anthropometric parameters was evaluated.
The concentrations of nesfatin-1, ghrelin and insulin and the homeostasis model assessment-insulin resistance index (HOMA-IR) were higher in SGA than AGA infants (p=0.0358, 0.0163, 0.0001 and 0.0051, respectively), but IGF-1 levels and homeostasis model assessment-insulin sensitivity index (HOMA-ISI) were lower (p=0.033 and 0.0001, respectively). Nesfatin-1 levels in SGA infants were higher on postnatal day 0 (PND0) than in AGA infants (p=0.0358) and lower on PND7 (p=0.0002) and PND28 (p=0.0488). A negative correlation showed between nesfatin-1 and oral calorie intake (r=–0.446; p=0.017) and HOMA-ISI (r=–0.398; p=0.036), and a positive correlation between nesfatin-1 and HOMA-IR (r=0.43; p=0.023) in SGA infants.
Nesfatin-1 is involved in the physiological regulation of intrauterine and postnatal growth and development in SGA infants.</abstract><cop>Germany</cop><pub>De Gruyter</pub><pmid>23155701</pmid><doi>10.1515/jpem-2012-0095</doi><tpages>6</tpages></addata></record> |
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| identifier | ISSN: 0334-018X |
| ispartof | Journal of Pediatric Endocrinology and Metabolism, 2012-08, Vol.25 (7), p.727-732 |
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| source | MEDLINE; De Gruyter journals |
| subjects | Anthropometry Body Weights and Measures Calcium-Binding Proteins - blood Calcium-Binding Proteins - metabolism Calcium-Binding Proteins - physiology Child Development - physiology Cohort Studies DNA-Binding Proteins - blood DNA-Binding Proteins - metabolism DNA-Binding Proteins - physiology Endocrine System - metabolism Endocrine System - physiology energy homeostasis Female Gestational Age growth and development Humans Infant, Newborn - blood Infant, Newborn - growth & development Infant, Newborn - metabolism Infant, Premature - blood Infant, Premature - growth & development Infant, Premature - metabolism Infant, Premature - physiology Infant, Small for Gestational Age - blood Infant, Small for Gestational Age - growth & development Infant, Small for Gestational Age - metabolism Infant, Small for Gestational Age - physiology Male Metabolism - physiology Nerve Tissue Proteins - blood Nerve Tissue Proteins - metabolism Nerve Tissue Proteins - physiology nesfatin-1 newborn Term Birth - blood Term Birth - metabolism Term Birth - physiology |
| title | Nesfatin-1 in newborns: relationship with endocrine and metabolic and anthropometric measures |
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