Effects of selenium supplementation on antibodies of autoimmune thyroiditis
To evaluate the effects of selenium (Se) supplementation on concentrations of thyroid peroxidase antibodies (TPOAb) and TPOAb IgG subclasses in autoimmune thyroiditis (AIT) patients with different thyroid functional status. A blind and placebo-controlled prospective study was performed for a total o...
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| Veröffentlicht in: | Zhong hua yi xue za zhi 2012-08, Vol.92 (32), p.2256-2260 |
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| container_issue | 32 |
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| container_title | Zhong hua yi xue za zhi |
| container_volume | 92 |
| creator | Zhu, Lin Bai, Xue Teng, Wei-ping Shan, Zhong-yan Wang, Wei-wei Fan, Chen-ling Wang, Hong Zhang, Hong-mei |
| description | To evaluate the effects of selenium (Se) supplementation on concentrations of thyroid peroxidase antibodies (TPOAb) and TPOAb IgG subclasses in autoimmune thyroiditis (AIT) patients with different thyroid functional status.
A blind and placebo-controlled prospective study was performed for a total of 134 cases with AIT and thyroid peroxidase antibodies above 300 U/ml. Their mean age was 41 years (range: 15-70). All of them were recruited from Department of Endocrinology, First Affiliated Hospital of China Medical University from June 2008 to June 2009 and divided into 2 groups according to thyroid function: euthyroidism or subclinical hypothyroidism (n = 89) and hypothyroidism (n = 45). Then they were randomized into 2 groups: selenium-treated and placebo-treated. And 49 cases in subclinical autoimmune thyroiditis group and 28 cases in hypothyroidism group received 200 µg oral selenium yeast daily for 6 months while others placebo. Serum concentrations of TPOAb, TPOAb IgG subclasses, thyroid-stimulating hormo |
| doi_str_mv | 10.3760/cma.j.issn.0376-2491.2012.32.008 |
| format | Article |
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A blind and placebo-controlled prospective study was performed for a total of 134 cases with AIT and thyroid peroxidase antibodies above 300 U/ml. Their mean age was 41 years (range: 15-70). All of them were recruited from Department of Endocrinology, First Affiliated Hospital of China Medical University from June 2008 to June 2009 and divided into 2 groups according to thyroid function: euthyroidism or subclinical hypothyroidism (n = 89) and hypothyroidism (n = 45). Then they were randomized into 2 groups: selenium-treated and placebo-treated. And 49 cases in subclinical autoimmune thyroiditis group and 28 cases in hypothyroidism group received 200 µg oral selenium yeast daily for 6 months while others placebo. Serum concentrations of TPOAb, TPOAb IgG subclasses, thyroid-stimulating hormo</description><identifier>ISSN: 0376-2491</identifier><identifier>DOI: 10.3760/cma.j.issn.0376-2491.2012.32.008</identifier><identifier>PMID: 23158484</identifier><language>chi</language><publisher>China</publisher><subject>Adolescent ; Adult ; Aged ; Autoantibodies - blood ; Autoantibodies - classification ; Double-Blind Method ; Humans ; Iodide Peroxidase - immunology ; Middle Aged ; Selenium - therapeutic use ; Thyroiditis, Autoimmune - blood ; Thyroiditis, Autoimmune - drug therapy ; Young Adult</subject><ispartof>Zhong hua yi xue za zhi, 2012-08, Vol.92 (32), p.2256-2260</ispartof><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23158484$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhu, Lin</creatorcontrib><creatorcontrib>Bai, Xue</creatorcontrib><creatorcontrib>Teng, Wei-ping</creatorcontrib><creatorcontrib>Shan, Zhong-yan</creatorcontrib><creatorcontrib>Wang, Wei-wei</creatorcontrib><creatorcontrib>Fan, Chen-ling</creatorcontrib><creatorcontrib>Wang, Hong</creatorcontrib><creatorcontrib>Zhang, Hong-mei</creatorcontrib><title>Effects of selenium supplementation on antibodies of autoimmune thyroiditis</title><title>Zhong hua yi xue za zhi</title><addtitle>Zhonghua Yi Xue Za Zhi</addtitle><description>To evaluate the effects of selenium (Se) supplementation on concentrations of thyroid peroxidase antibodies (TPOAb) and TPOAb IgG subclasses in autoimmune thyroiditis (AIT) patients with different thyroid functional status.
A blind and placebo-controlled prospective study was performed for a total of 134 cases with AIT and thyroid peroxidase antibodies above 300 U/ml. Their mean age was 41 years (range: 15-70). All of them were recruited from Department of Endocrinology, First Affiliated Hospital of China Medical University from June 2008 to June 2009 and divided into 2 groups according to thyroid function: euthyroidism or subclinical hypothyroidism (n = 89) and hypothyroidism (n = 45). Then they were randomized into 2 groups: selenium-treated and placebo-treated. And 49 cases in subclinical autoimmune thyroiditis group and 28 cases in hypothyroidism group received 200 µg oral selenium yeast daily for 6 months while others placebo. Serum concentrations of TPOAb, TPOAb IgG subclasses, thyroid-stimulating hormo</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Autoantibodies - blood</subject><subject>Autoantibodies - classification</subject><subject>Double-Blind Method</subject><subject>Humans</subject><subject>Iodide Peroxidase - immunology</subject><subject>Middle Aged</subject><subject>Selenium - therapeutic use</subject><subject>Thyroiditis, Autoimmune - blood</subject><subject>Thyroiditis, Autoimmune - drug therapy</subject><subject>Young Adult</subject><issn>0376-2491</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kMtqwzAURLVoaUKaXyheZmNXupJtaVlC-qCBbtq1ubYkqmJZriUt8vcNfcHAwOEwiyFkx2jF24beDh6rj8rFOFX0DEoQilVAGVQcKkrlBVn_8xXZxuh6KlqugAK7IivgrJZCijV5PlhrhhSLYItoRjO57IuY53k03kwJkwtTcQ5OyfVBO_NtYk7BeZ8nU6T30xKcdsnFa3JpcYxm-9sb8nZ_eN0_lseXh6f93bGcGTSprG1To9QSJe-xVqKXCjUTlGrsW9HAoORgQUENzQCit3UjFEpsraHYcqb5hux-duclfGYTU-ddHMw44mRCjh1jrWwkCKnO6s2vmntvdDcvzuNy6v4O4F9iX2G4</recordid><startdate>20120828</startdate><enddate>20120828</enddate><creator>Zhu, Lin</creator><creator>Bai, Xue</creator><creator>Teng, Wei-ping</creator><creator>Shan, Zhong-yan</creator><creator>Wang, Wei-wei</creator><creator>Fan, Chen-ling</creator><creator>Wang, Hong</creator><creator>Zhang, Hong-mei</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20120828</creationdate><title>Effects of selenium supplementation on antibodies of autoimmune thyroiditis</title><author>Zhu, Lin ; Bai, Xue ; Teng, Wei-ping ; Shan, Zhong-yan ; Wang, Wei-wei ; Fan, Chen-ling ; Wang, Hong ; Zhang, Hong-mei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p126t-5f65a8d8a83ba594b89ad1400dab7462c98cf292526c24bf5649a8a7fe0a731d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>chi</language><creationdate>2012</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Autoantibodies - blood</topic><topic>Autoantibodies - classification</topic><topic>Double-Blind Method</topic><topic>Humans</topic><topic>Iodide Peroxidase - immunology</topic><topic>Middle Aged</topic><topic>Selenium - therapeutic use</topic><topic>Thyroiditis, Autoimmune - blood</topic><topic>Thyroiditis, Autoimmune - drug therapy</topic><topic>Young Adult</topic><toplevel>online_resources</toplevel><creatorcontrib>Zhu, Lin</creatorcontrib><creatorcontrib>Bai, Xue</creatorcontrib><creatorcontrib>Teng, Wei-ping</creatorcontrib><creatorcontrib>Shan, Zhong-yan</creatorcontrib><creatorcontrib>Wang, Wei-wei</creatorcontrib><creatorcontrib>Fan, Chen-ling</creatorcontrib><creatorcontrib>Wang, Hong</creatorcontrib><creatorcontrib>Zhang, Hong-mei</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Zhong hua yi xue za zhi</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhu, Lin</au><au>Bai, Xue</au><au>Teng, Wei-ping</au><au>Shan, Zhong-yan</au><au>Wang, Wei-wei</au><au>Fan, Chen-ling</au><au>Wang, Hong</au><au>Zhang, Hong-mei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of selenium supplementation on antibodies of autoimmune thyroiditis</atitle><jtitle>Zhong hua yi xue za zhi</jtitle><addtitle>Zhonghua Yi Xue Za Zhi</addtitle><date>2012-08-28</date><risdate>2012</risdate><volume>92</volume><issue>32</issue><spage>2256</spage><epage>2260</epage><pages>2256-2260</pages><issn>0376-2491</issn><abstract>To evaluate the effects of selenium (Se) supplementation on concentrations of thyroid peroxidase antibodies (TPOAb) and TPOAb IgG subclasses in autoimmune thyroiditis (AIT) patients with different thyroid functional status.
A blind and placebo-controlled prospective study was performed for a total of 134 cases with AIT and thyroid peroxidase antibodies above 300 U/ml. Their mean age was 41 years (range: 15-70). All of them were recruited from Department of Endocrinology, First Affiliated Hospital of China Medical University from June 2008 to June 2009 and divided into 2 groups according to thyroid function: euthyroidism or subclinical hypothyroidism (n = 89) and hypothyroidism (n = 45). Then they were randomized into 2 groups: selenium-treated and placebo-treated. And 49 cases in subclinical autoimmune thyroiditis group and 28 cases in hypothyroidism group received 200 µg oral selenium yeast daily for 6 months while others placebo. Serum concentrations of TPOAb, TPOAb IgG subclasses, thyroid-stimulating hormo</abstract><cop>China</cop><pmid>23158484</pmid><doi>10.3760/cma.j.issn.0376-2491.2012.32.008</doi><tpages>5</tpages></addata></record> |
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| ispartof | Zhong hua yi xue za zhi, 2012-08, Vol.92 (32), p.2256-2260 |
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| language | chi |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Adolescent Adult Aged Autoantibodies - blood Autoantibodies - classification Double-Blind Method Humans Iodide Peroxidase - immunology Middle Aged Selenium - therapeutic use Thyroiditis, Autoimmune - blood Thyroiditis, Autoimmune - drug therapy Young Adult |
| title | Effects of selenium supplementation on antibodies of autoimmune thyroiditis |
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