Evidence for the accumulation of Abeta immunoreactive material in the human brain and in transgenic animal models
In this review we highlight the evidence for an intracellular origin of Abeta (Aβ) amyloid peptides as well as the observations for a pathological accumulation of these peptides in Alzheimer's disease and Down syndrome, as well as in transgenic animal models. We deliberate on the controversy as...
Gespeichert in:
| Veröffentlicht in: | Life sciences (1973) 2012-12, Vol.91 (23-24), p.1141-1147 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1147 |
|---|---|
| container_issue | 23-24 |
| container_start_page | 1141 |
| container_title | Life sciences (1973) |
| container_volume | 91 |
| creator | Cuello, A. Claudio Allard, Simon Ferretti, Maria Teresa |
| description | In this review we highlight the evidence for an intracellular origin of Abeta (Aβ) amyloid peptides as well as the observations for a pathological accumulation of these peptides in Alzheimer's disease and Down syndrome, as well as in transgenic animal models. We deliberate on the controversy as to whether the intracellular Aβ immunoreactive material is simply an accumulation of unprocessed full length amyloid precursor protein (APP) or a mix of processed APP fragments including Aβ. Finally, we discuss the possible pathological significance of these intracellular APP fragments and the expected future research directions regarding this thought-provoking problem. |
| doi_str_mv | 10.1016/j.lfs.2012.05.020 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1178681550</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0024320512002949</els_id><sourcerecordid>1178681550</sourcerecordid><originalsourceid>FETCH-LOGICAL-c410t-ea0d42317b4b5240425d45f2186252abf66a9ed51f7e473a4cbc26276ec1ca693</originalsourceid><addsrcrecordid>eNp9kcFO3DAQhq2qqCy0D9BL62MvCWPHTnbVE0K0VELiQDlbE2cMXsUx2MlKvH29u7THHizLo-8f_frM2GcBtQDRXmzr0eVagpA16BokvGMrse42FbSNeM9WAFJVjQR9ys5y3gKA1l3zgZ1K2YFuYLNiL9c7P9BkibuY-PxEHK1dwjLi7OPEo-OXPc3IfQjLFBOhnf2OeMCZkseR--kQeloCTrxPWN44DYdxwik_0uRtmfhQ2BAHGvNHduJwzPTp7T5nDz-uf1_dVLd3P39dXd5WVgmYK0IYlGxE16teSwVK6kFpJ8W6lVpi79oWNzRo4TpSXYPK9la2smvJCovtpjln3457n1N8WSjPJvhsaRxxorhkI0S3btdCayioOKI2xZwTOfOcSuP0agSYvWmzNcW02Zs2oE0xXTJf3tYvfaDhX-Kv2gJ8PQIOo8HH5LN5uC8bNJQj5aHh9yNRrNDOUzLZ-v1fDD6Rnc0Q_X8K_AHwOZg4</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1178681550</pqid></control><display><type>article</type><title>Evidence for the accumulation of Abeta immunoreactive material in the human brain and in transgenic animal models</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Cuello, A. Claudio ; Allard, Simon ; Ferretti, Maria Teresa</creator><creatorcontrib>Cuello, A. Claudio ; Allard, Simon ; Ferretti, Maria Teresa</creatorcontrib><description>In this review we highlight the evidence for an intracellular origin of Abeta (Aβ) amyloid peptides as well as the observations for a pathological accumulation of these peptides in Alzheimer's disease and Down syndrome, as well as in transgenic animal models. We deliberate on the controversy as to whether the intracellular Aβ immunoreactive material is simply an accumulation of unprocessed full length amyloid precursor protein (APP) or a mix of processed APP fragments including Aβ. Finally, we discuss the possible pathological significance of these intracellular APP fragments and the expected future research directions regarding this thought-provoking problem.</description><identifier>ISSN: 0024-3205</identifier><identifier>EISSN: 1879-0631</identifier><identifier>DOI: 10.1016/j.lfs.2012.05.020</identifier><identifier>PMID: 22705309</identifier><language>eng</language><publisher>Netherlands: Elsevier Inc</publisher><subject>Abeta amyloid peptides ; Alzheimer disease ; Alzheimer Disease - metabolism ; Alzheimer Disease - pathology ; Alzheimer's disease ; amyloid ; Amyloid beta-Peptides - metabolism ; Amyloid precursor protein ; animal models ; Animals ; Animals, Genetically Modified ; brain ; Brain - metabolism ; Brain - pathology ; Down syndrome ; Down Syndrome - metabolism ; Down Syndrome - pathology ; Humans ; Intracellular Abeta ; Intracellular Signaling Peptides and Proteins - metabolism ; Mice ; peptides ; Rats ; transgenic animals</subject><ispartof>Life sciences (1973), 2012-12, Vol.91 (23-24), p.1141-1147</ispartof><rights>2012 Elsevier Inc.</rights><rights>Copyright © 2012 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c410t-ea0d42317b4b5240425d45f2186252abf66a9ed51f7e473a4cbc26276ec1ca693</citedby><cites>FETCH-LOGICAL-c410t-ea0d42317b4b5240425d45f2186252abf66a9ed51f7e473a4cbc26276ec1ca693</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0024320512002949$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22705309$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cuello, A. Claudio</creatorcontrib><creatorcontrib>Allard, Simon</creatorcontrib><creatorcontrib>Ferretti, Maria Teresa</creatorcontrib><title>Evidence for the accumulation of Abeta immunoreactive material in the human brain and in transgenic animal models</title><title>Life sciences (1973)</title><addtitle>Life Sci</addtitle><description>In this review we highlight the evidence for an intracellular origin of Abeta (Aβ) amyloid peptides as well as the observations for a pathological accumulation of these peptides in Alzheimer's disease and Down syndrome, as well as in transgenic animal models. We deliberate on the controversy as to whether the intracellular Aβ immunoreactive material is simply an accumulation of unprocessed full length amyloid precursor protein (APP) or a mix of processed APP fragments including Aβ. Finally, we discuss the possible pathological significance of these intracellular APP fragments and the expected future research directions regarding this thought-provoking problem.</description><subject>Abeta amyloid peptides</subject><subject>Alzheimer disease</subject><subject>Alzheimer Disease - metabolism</subject><subject>Alzheimer Disease - pathology</subject><subject>Alzheimer's disease</subject><subject>amyloid</subject><subject>Amyloid beta-Peptides - metabolism</subject><subject>Amyloid precursor protein</subject><subject>animal models</subject><subject>Animals</subject><subject>Animals, Genetically Modified</subject><subject>brain</subject><subject>Brain - metabolism</subject><subject>Brain - pathology</subject><subject>Down syndrome</subject><subject>Down Syndrome - metabolism</subject><subject>Down Syndrome - pathology</subject><subject>Humans</subject><subject>Intracellular Abeta</subject><subject>Intracellular Signaling Peptides and Proteins - metabolism</subject><subject>Mice</subject><subject>peptides</subject><subject>Rats</subject><subject>transgenic animals</subject><issn>0024-3205</issn><issn>1879-0631</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kcFO3DAQhq2qqCy0D9BL62MvCWPHTnbVE0K0VELiQDlbE2cMXsUx2MlKvH29u7THHizLo-8f_frM2GcBtQDRXmzr0eVagpA16BokvGMrse42FbSNeM9WAFJVjQR9ys5y3gKA1l3zgZ1K2YFuYLNiL9c7P9BkibuY-PxEHK1dwjLi7OPEo-OXPc3IfQjLFBOhnf2OeMCZkseR--kQeloCTrxPWN44DYdxwik_0uRtmfhQ2BAHGvNHduJwzPTp7T5nDz-uf1_dVLd3P39dXd5WVgmYK0IYlGxE16teSwVK6kFpJ8W6lVpi79oWNzRo4TpSXYPK9la2smvJCovtpjln3457n1N8WSjPJvhsaRxxorhkI0S3btdCayioOKI2xZwTOfOcSuP0agSYvWmzNcW02Zs2oE0xXTJf3tYvfaDhX-Kv2gJ8PQIOo8HH5LN5uC8bNJQj5aHh9yNRrNDOUzLZ-v1fDD6Rnc0Q_X8K_AHwOZg4</recordid><startdate>20121210</startdate><enddate>20121210</enddate><creator>Cuello, A. Claudio</creator><creator>Allard, Simon</creator><creator>Ferretti, Maria Teresa</creator><general>Elsevier Inc</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20121210</creationdate><title>Evidence for the accumulation of Abeta immunoreactive material in the human brain and in transgenic animal models</title><author>Cuello, A. Claudio ; Allard, Simon ; Ferretti, Maria Teresa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c410t-ea0d42317b4b5240425d45f2186252abf66a9ed51f7e473a4cbc26276ec1ca693</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Abeta amyloid peptides</topic><topic>Alzheimer disease</topic><topic>Alzheimer Disease - metabolism</topic><topic>Alzheimer Disease - pathology</topic><topic>Alzheimer's disease</topic><topic>amyloid</topic><topic>Amyloid beta-Peptides - metabolism</topic><topic>Amyloid precursor protein</topic><topic>animal models</topic><topic>Animals</topic><topic>Animals, Genetically Modified</topic><topic>brain</topic><topic>Brain - metabolism</topic><topic>Brain - pathology</topic><topic>Down syndrome</topic><topic>Down Syndrome - metabolism</topic><topic>Down Syndrome - pathology</topic><topic>Humans</topic><topic>Intracellular Abeta</topic><topic>Intracellular Signaling Peptides and Proteins - metabolism</topic><topic>Mice</topic><topic>peptides</topic><topic>Rats</topic><topic>transgenic animals</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cuello, A. Claudio</creatorcontrib><creatorcontrib>Allard, Simon</creatorcontrib><creatorcontrib>Ferretti, Maria Teresa</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Life sciences (1973)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cuello, A. Claudio</au><au>Allard, Simon</au><au>Ferretti, Maria Teresa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evidence for the accumulation of Abeta immunoreactive material in the human brain and in transgenic animal models</atitle><jtitle>Life sciences (1973)</jtitle><addtitle>Life Sci</addtitle><date>2012-12-10</date><risdate>2012</risdate><volume>91</volume><issue>23-24</issue><spage>1141</spage><epage>1147</epage><pages>1141-1147</pages><issn>0024-3205</issn><eissn>1879-0631</eissn><abstract>In this review we highlight the evidence for an intracellular origin of Abeta (Aβ) amyloid peptides as well as the observations for a pathological accumulation of these peptides in Alzheimer's disease and Down syndrome, as well as in transgenic animal models. We deliberate on the controversy as to whether the intracellular Aβ immunoreactive material is simply an accumulation of unprocessed full length amyloid precursor protein (APP) or a mix of processed APP fragments including Aβ. Finally, we discuss the possible pathological significance of these intracellular APP fragments and the expected future research directions regarding this thought-provoking problem.</abstract><cop>Netherlands</cop><pub>Elsevier Inc</pub><pmid>22705309</pmid><doi>10.1016/j.lfs.2012.05.020</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0024-3205 |
| ispartof | Life sciences (1973), 2012-12, Vol.91 (23-24), p.1141-1147 |
| issn | 0024-3205 1879-0631 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1178681550 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Abeta amyloid peptides Alzheimer disease Alzheimer Disease - metabolism Alzheimer Disease - pathology Alzheimer's disease amyloid Amyloid beta-Peptides - metabolism Amyloid precursor protein animal models Animals Animals, Genetically Modified brain Brain - metabolism Brain - pathology Down syndrome Down Syndrome - metabolism Down Syndrome - pathology Humans Intracellular Abeta Intracellular Signaling Peptides and Proteins - metabolism Mice peptides Rats transgenic animals |
| title | Evidence for the accumulation of Abeta immunoreactive material in the human brain and in transgenic animal models |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-28T13%3A11%3A05IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Evidence%20for%20the%20accumulation%20of%20Abeta%20immunoreactive%20material%20in%20the%20human%20brain%20and%20in%20transgenic%20animal%20models&rft.jtitle=Life%20sciences%20(1973)&rft.au=Cuello,%20A.%20Claudio&rft.date=2012-12-10&rft.volume=91&rft.issue=23-24&rft.spage=1141&rft.epage=1147&rft.pages=1141-1147&rft.issn=0024-3205&rft.eissn=1879-0631&rft_id=info:doi/10.1016/j.lfs.2012.05.020&rft_dat=%3Cproquest_cross%3E1178681550%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1178681550&rft_id=info:pmid/22705309&rft_els_id=S0024320512002949&rfr_iscdi=true |