Small, nonfunctioning, asymptomatic pancreatic neuroendocrine tumors (PNETs): Role for nonoperative management
Background Controversy exists regarding the optimal management of incidentally discovered, small pancreatic neuroendocrine tumors (PNETs). Our aim was to review the outcomes of patients who underwent nonoperative and operative management. Methods We retrospectively reviewed patients with nonfunction...
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| Veröffentlicht in: | Surgery 2012-12, Vol.152 (6), p.965-974 |
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| creator | Lee, Louis C., MD Grant, Clive S., MD Salomao, Diva R., MD Fletcher, Joel G., MD Takahashi, Naoki, MD Fidler, Jeff L., MD Levy, Michael J., MD Huebner, Marianne, PhD |
| description | Background Controversy exists regarding the optimal management of incidentally discovered, small pancreatic neuroendocrine tumors (PNETs). Our aim was to review the outcomes of patients who underwent nonoperative and operative management. Methods We retrospectively reviewed patients with nonfunctioning PNETs at our institution from January 1, 2000 to June 30, 2011. Patients were included if the tumor was sporadic and |
| doi_str_mv | 10.1016/j.surg.2012.08.038 |
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| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1178680503</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S003960601200493X</els_id><sourcerecordid>1178680503</sourcerecordid><originalsourceid>FETCH-LOGICAL-c540t-c838c7ce6aabca1f8cd4f57101147db979f4c10d1d4529f6371b017d1a8adb0a3</originalsourceid><addsrcrecordid>eNp9kk2L1TAUhosoznX0D7iQboQRpvWcpk3aQQQZxg8YVJwR3IU0Pb3k2iY1aQfuvzf1XhVcuEoWz_sm5-EkyVOEHAH5y10eFr_NC8AihzoHVt9LNlixIhOM4_1kA8CajAOHk-RRCDsAaEqsHyYnBUMouGg2ib0Z1TCcp9bZfrF6Ns4auz1PVdiP0-xGNRudTspqT7-ulhbvyHZOe2MpnZfR-ZCeff54dRteXKRf3EBp7_za5ybyMXNH6ais2tJIdn6cPOjVEOjJ8TxNvr69ur18n11_evfh8s11pqsS5kzXrNZCE1eq1Qr7WndlX4k4NZaiaxvR9KVG6LArq6LpORPYAooOVa26FhQ7Tc4OvZN3PxYKsxxN0DQMypJbgkQUNa-hAhbR4oBq70Lw1MvJm1H5vUSQq2e5k6tnuXqWUMvoOYaeHfuXdqTuT-S32Ag8PwIqaDX0Pio04S_HRQG8WIteHTiKNu4MeRm0IaupM570LDtn_v-P1__E9WCsiS9-pz2FnVu8jZ4lyhAz8mbdiHUhsAAoG_aN_QQ1v7KM</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1178680503</pqid></control><display><type>article</type><title>Small, nonfunctioning, asymptomatic pancreatic neuroendocrine tumors (PNETs): Role for nonoperative management</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Lee, Louis C., MD ; Grant, Clive S., MD ; Salomao, Diva R., MD ; Fletcher, Joel G., MD ; Takahashi, Naoki, MD ; Fidler, Jeff L., MD ; Levy, Michael J., MD ; Huebner, Marianne, PhD</creator><creatorcontrib>Lee, Louis C., MD ; Grant, Clive S., MD ; Salomao, Diva R., MD ; Fletcher, Joel G., MD ; Takahashi, Naoki, MD ; Fidler, Jeff L., MD ; Levy, Michael J., MD ; Huebner, Marianne, PhD</creatorcontrib><description>Background Controversy exists regarding the optimal management of incidentally discovered, small pancreatic neuroendocrine tumors (PNETs). Our aim was to review the outcomes of patients who underwent nonoperative and operative management. Methods We retrospectively reviewed patients with nonfunctioning PNETs at our institution from January 1, 2000 to June 30, 2011. Patients were included if the tumor was sporadic and <4 cm without radiographic evidence of local invasion or metastases. Results Nonoperative patients ( n = 77, median age, 67 years; range, 31–94) had a median tumor size of 1.0 cm (range, 0.3–3.2). Mean follow-up (F/U) was 45 months (max. 153 months). Median tumor size did not change throughout F/U; there was no disease progression or disease specific mortality. In the operative group ( n = 56, median age, 60 years; range, 27–82), median neoplasm size was 1.8 cm (range, 0.5–3.6). Mean F/U was 52 months (max. 138 months). A total of 46% of the operative patients had some type of complication, more than half due to a clinically significant pancreatic leak. No recurrence or disease specific mortality was seen in the operative group, including 5 patients with positive lymph nodes. Conclusion Small nonfunctioning PNETs usually exhibit minimal or no growth over many years. Nonoperative management may be advocated when serial imaging demonstrates minimal or no growth without suspicious features.</description><identifier>ISSN: 0039-6060</identifier><identifier>EISSN: 1532-7361</identifier><identifier>DOI: 10.1016/j.surg.2012.08.038</identifier><identifier>PMID: 23102679</identifier><identifier>CODEN: SURGAZ</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Asymptomatic Diseases - therapy ; Biological and medical sciences ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; General aspects ; Humans ; Liver. Biliary tract. Portal circulation. Exocrine pancreas ; Male ; Medical sciences ; Middle Aged ; Neuroendocrine Tumors - diagnosis ; Neuroendocrine Tumors - pathology ; Neuroendocrine Tumors - surgery ; Neuroendocrine Tumors - therapy ; Pancreatectomy ; Pancreatic Neoplasms - diagnosis ; Pancreatic Neoplasms - pathology ; Pancreatic Neoplasms - surgery ; Pancreatic Neoplasms - therapy ; Postoperative Complications ; Surgery ; Tumors</subject><ispartof>Surgery, 2012-12, Vol.152 (6), p.965-974</ispartof><rights>Mosby, Inc.</rights><rights>2012 Mosby, Inc.</rights><rights>2014 INIST-CNRS</rights><rights>Copyright © 2012 Mosby, Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c540t-c838c7ce6aabca1f8cd4f57101147db979f4c10d1d4529f6371b017d1a8adb0a3</citedby><cites>FETCH-LOGICAL-c540t-c838c7ce6aabca1f8cd4f57101147db979f4c10d1d4529f6371b017d1a8adb0a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S003960601200493X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26720628$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23102679$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, Louis C., MD</creatorcontrib><creatorcontrib>Grant, Clive S., MD</creatorcontrib><creatorcontrib>Salomao, Diva R., MD</creatorcontrib><creatorcontrib>Fletcher, Joel G., MD</creatorcontrib><creatorcontrib>Takahashi, Naoki, MD</creatorcontrib><creatorcontrib>Fidler, Jeff L., MD</creatorcontrib><creatorcontrib>Levy, Michael J., MD</creatorcontrib><creatorcontrib>Huebner, Marianne, PhD</creatorcontrib><title>Small, nonfunctioning, asymptomatic pancreatic neuroendocrine tumors (PNETs): Role for nonoperative management</title><title>Surgery</title><addtitle>Surgery</addtitle><description>Background Controversy exists regarding the optimal management of incidentally discovered, small pancreatic neuroendocrine tumors (PNETs). Our aim was to review the outcomes of patients who underwent nonoperative and operative management. Methods We retrospectively reviewed patients with nonfunctioning PNETs at our institution from January 1, 2000 to June 30, 2011. Patients were included if the tumor was sporadic and <4 cm without radiographic evidence of local invasion or metastases. Results Nonoperative patients ( n = 77, median age, 67 years; range, 31–94) had a median tumor size of 1.0 cm (range, 0.3–3.2). Mean follow-up (F/U) was 45 months (max. 153 months). Median tumor size did not change throughout F/U; there was no disease progression or disease specific mortality. In the operative group ( n = 56, median age, 60 years; range, 27–82), median neoplasm size was 1.8 cm (range, 0.5–3.6). Mean F/U was 52 months (max. 138 months). A total of 46% of the operative patients had some type of complication, more than half due to a clinically significant pancreatic leak. No recurrence or disease specific mortality was seen in the operative group, including 5 patients with positive lymph nodes. Conclusion Small nonfunctioning PNETs usually exhibit minimal or no growth over many years. Nonoperative management may be advocated when serial imaging demonstrates minimal or no growth without suspicious features.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Asymptomatic Diseases - therapy</subject><subject>Biological and medical sciences</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>General aspects</subject><subject>Humans</subject><subject>Liver. Biliary tract. Portal circulation. Exocrine pancreas</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neuroendocrine Tumors - diagnosis</subject><subject>Neuroendocrine Tumors - pathology</subject><subject>Neuroendocrine Tumors - surgery</subject><subject>Neuroendocrine Tumors - therapy</subject><subject>Pancreatectomy</subject><subject>Pancreatic Neoplasms - diagnosis</subject><subject>Pancreatic Neoplasms - pathology</subject><subject>Pancreatic Neoplasms - surgery</subject><subject>Pancreatic Neoplasms - therapy</subject><subject>Postoperative Complications</subject><subject>Surgery</subject><subject>Tumors</subject><issn>0039-6060</issn><issn>1532-7361</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kk2L1TAUhosoznX0D7iQboQRpvWcpk3aQQQZxg8YVJwR3IU0Pb3k2iY1aQfuvzf1XhVcuEoWz_sm5-EkyVOEHAH5y10eFr_NC8AihzoHVt9LNlixIhOM4_1kA8CajAOHk-RRCDsAaEqsHyYnBUMouGg2ib0Z1TCcp9bZfrF6Ns4auz1PVdiP0-xGNRudTspqT7-ulhbvyHZOe2MpnZfR-ZCeff54dRteXKRf3EBp7_za5ybyMXNH6ais2tJIdn6cPOjVEOjJ8TxNvr69ur18n11_evfh8s11pqsS5kzXrNZCE1eq1Qr7WndlX4k4NZaiaxvR9KVG6LArq6LpORPYAooOVa26FhQ7Tc4OvZN3PxYKsxxN0DQMypJbgkQUNa-hAhbR4oBq70Lw1MvJm1H5vUSQq2e5k6tnuXqWUMvoOYaeHfuXdqTuT-S32Ag8PwIqaDX0Pio04S_HRQG8WIteHTiKNu4MeRm0IaupM570LDtn_v-P1__E9WCsiS9-pz2FnVu8jZ4lyhAz8mbdiHUhsAAoG_aN_QQ1v7KM</recordid><startdate>20121201</startdate><enddate>20121201</enddate><creator>Lee, Louis C., MD</creator><creator>Grant, Clive S., MD</creator><creator>Salomao, Diva R., MD</creator><creator>Fletcher, Joel G., MD</creator><creator>Takahashi, Naoki, MD</creator><creator>Fidler, Jeff L., MD</creator><creator>Levy, Michael J., MD</creator><creator>Huebner, Marianne, PhD</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20121201</creationdate><title>Small, nonfunctioning, asymptomatic pancreatic neuroendocrine tumors (PNETs): Role for nonoperative management</title><author>Lee, Louis C., MD ; Grant, Clive S., MD ; Salomao, Diva R., MD ; Fletcher, Joel G., MD ; Takahashi, Naoki, MD ; Fidler, Jeff L., MD ; Levy, Michael J., MD ; Huebner, Marianne, PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c540t-c838c7ce6aabca1f8cd4f57101147db979f4c10d1d4529f6371b017d1a8adb0a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Asymptomatic Diseases - therapy</topic><topic>Biological and medical sciences</topic><topic>Female</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>General aspects</topic><topic>Humans</topic><topic>Liver. Biliary tract. Portal circulation. Exocrine pancreas</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neuroendocrine Tumors - diagnosis</topic><topic>Neuroendocrine Tumors - pathology</topic><topic>Neuroendocrine Tumors - surgery</topic><topic>Neuroendocrine Tumors - therapy</topic><topic>Pancreatectomy</topic><topic>Pancreatic Neoplasms - diagnosis</topic><topic>Pancreatic Neoplasms - pathology</topic><topic>Pancreatic Neoplasms - surgery</topic><topic>Pancreatic Neoplasms - therapy</topic><topic>Postoperative Complications</topic><topic>Surgery</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Louis C., MD</creatorcontrib><creatorcontrib>Grant, Clive S., MD</creatorcontrib><creatorcontrib>Salomao, Diva R., MD</creatorcontrib><creatorcontrib>Fletcher, Joel G., MD</creatorcontrib><creatorcontrib>Takahashi, Naoki, MD</creatorcontrib><creatorcontrib>Fidler, Jeff L., MD</creatorcontrib><creatorcontrib>Levy, Michael J., MD</creatorcontrib><creatorcontrib>Huebner, Marianne, PhD</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Louis C., MD</au><au>Grant, Clive S., MD</au><au>Salomao, Diva R., MD</au><au>Fletcher, Joel G., MD</au><au>Takahashi, Naoki, MD</au><au>Fidler, Jeff L., MD</au><au>Levy, Michael J., MD</au><au>Huebner, Marianne, PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Small, nonfunctioning, asymptomatic pancreatic neuroendocrine tumors (PNETs): Role for nonoperative management</atitle><jtitle>Surgery</jtitle><addtitle>Surgery</addtitle><date>2012-12-01</date><risdate>2012</risdate><volume>152</volume><issue>6</issue><spage>965</spage><epage>974</epage><pages>965-974</pages><issn>0039-6060</issn><eissn>1532-7361</eissn><coden>SURGAZ</coden><abstract>Background Controversy exists regarding the optimal management of incidentally discovered, small pancreatic neuroendocrine tumors (PNETs). Our aim was to review the outcomes of patients who underwent nonoperative and operative management. Methods We retrospectively reviewed patients with nonfunctioning PNETs at our institution from January 1, 2000 to June 30, 2011. Patients were included if the tumor was sporadic and <4 cm without radiographic evidence of local invasion or metastases. Results Nonoperative patients ( n = 77, median age, 67 years; range, 31–94) had a median tumor size of 1.0 cm (range, 0.3–3.2). Mean follow-up (F/U) was 45 months (max. 153 months). Median tumor size did not change throughout F/U; there was no disease progression or disease specific mortality. In the operative group ( n = 56, median age, 60 years; range, 27–82), median neoplasm size was 1.8 cm (range, 0.5–3.6). Mean F/U was 52 months (max. 138 months). A total of 46% of the operative patients had some type of complication, more than half due to a clinically significant pancreatic leak. No recurrence or disease specific mortality was seen in the operative group, including 5 patients with positive lymph nodes. Conclusion Small nonfunctioning PNETs usually exhibit minimal or no growth over many years. Nonoperative management may be advocated when serial imaging demonstrates minimal or no growth without suspicious features.</abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>23102679</pmid><doi>10.1016/j.surg.2012.08.038</doi><tpages>10</tpages></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Asymptomatic Diseases - therapy Biological and medical sciences Female Gastroenterology. Liver. Pancreas. Abdomen General aspects Humans Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Medical sciences Middle Aged Neuroendocrine Tumors - diagnosis Neuroendocrine Tumors - pathology Neuroendocrine Tumors - surgery Neuroendocrine Tumors - therapy Pancreatectomy Pancreatic Neoplasms - diagnosis Pancreatic Neoplasms - pathology Pancreatic Neoplasms - surgery Pancreatic Neoplasms - therapy Postoperative Complications Surgery Tumors |
| title | Small, nonfunctioning, asymptomatic pancreatic neuroendocrine tumors (PNETs): Role for nonoperative management |
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