Association of Merkel cell polyomavirus infection with clinicopathological differences in Merkel cell carcinoma

Summary Merkel cell polyomavirus is a novel polyomavirus that is monoclonally integrated into genomes of up to 80% of human Merkel cell carcinomas. Merkel cell polyomavirus–positive Merkel cell carcinomas showed less metastatic tendency and better prognosis according to some reports, whereas others...

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Veröffentlicht in:	Human pathology 2012-12, Vol.43 (12), p.2282-2291
Hauptverfasser:	Higaki-Mori, Hiromi, MD, Kuwamoto, Satoshi, MD, PhD, Iwasaki, Takeshi, Kato, Masako, MD, PhD, Murakami, Ichiro, MD, PhD, Nagata, Keiko, MD, PhD, Sano, Hitoshi, MD, Horie, Yasushi, MD, PhD, Yoshida, Yuichi, MD, PhD, Yamamoto, Osamu, MD, PhD, Adachi, Kaori, Nanba, Eiji, MD, PhD, Hayashi, Kazuhiko, MD, PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Biological and medical sciences Carcinoma, Merkel Cell - metabolism Carcinoma, Merkel Cell - pathology Carcinoma, Merkel Cell - virology Cell cycle Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Clinicopathological differences Dermatology DNA Methylation Female Genes Hospitals Humans Immunohistochemistry Infections Investigative techniques, diagnostic techniques (general aspects) Male Medical sciences Merkel cell carcinoma Merkel cell polyomavirus Middle Aged Mutation Pathology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Polymerase chain reaction Polyomavirus Infections - metabolism Polyomavirus Infections - pathology Polyomavirus Infections - virology Promoter Regions, Genetic Proteins Skin Neoplasms - metabolism Skin Neoplasms - pathology Skin Neoplasms - virology TP53 mutation Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism Tumors of the skin and soft tissue. Premalignant lesions
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