Generalized flare of pustular psoriasis induced by PEGylated interferon-α2b therapy for chronic hepatitis C
ABSTRACT New onset or exacerbation of psoriasis vulgaris has been reported in a small number of patients after interferon (IFN)‐α therapy. Herein, we report a case of generalized flare of pustular psoriasis induced by PEGylated IFN‐α2b (PEG‐IFN‐α2b) in a 59‐year‐old woman with a 15‐year history of p...
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| Veröffentlicht in: | Australasian journal of dermatology 2012-11, Vol.53 (4), p.e69-e72 |
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| container_title | Australasian journal of dermatology |
| container_volume | 53 |
| creator | Wu, Meng-Chi Lee, J Yu-Yun |
| description | ABSTRACT
New onset or exacerbation of psoriasis vulgaris has been reported in a small number of patients after interferon (IFN)‐α therapy. Herein, we report a case of generalized flare of pustular psoriasis induced by PEGylated IFN‐α2b (PEG‐IFN‐α2b) in a 59‐year‐old woman with a 15‐year history of pustular psoriasis and chronic hepatitis C. Interferon‐α therapy was discontinued and the rash resolved after treatment with cyclosporin and systemic methylprednisolone. The potential side effect of PEG‐IFN‐α2b in inducing or exacerbating psoriasis should be kept in mind when treating patients with a history of psoriasis or pustular psoriasis. |
| doi_str_mv | 10.1111/j.1440-0960.2011.00767.x |
| format | Article |
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New onset or exacerbation of psoriasis vulgaris has been reported in a small number of patients after interferon (IFN)‐α therapy. Herein, we report a case of generalized flare of pustular psoriasis induced by PEGylated IFN‐α2b (PEG‐IFN‐α2b) in a 59‐year‐old woman with a 15‐year history of pustular psoriasis and chronic hepatitis C. Interferon‐α therapy was discontinued and the rash resolved after treatment with cyclosporin and systemic methylprednisolone. The potential side effect of PEG‐IFN‐α2b in inducing or exacerbating psoriasis should be kept in mind when treating patients with a history of psoriasis or pustular psoriasis.</description><identifier>ISSN: 0004-8380</identifier><identifier>EISSN: 1440-0960</identifier><identifier>DOI: 10.1111/j.1440-0960.2011.00767.x</identifier><identifier>PMID: 23157789</identifier><language>eng</language><publisher>Melbourne, Australia: Blackwell Publishing Asia</publisher><subject>Antiviral Agents - adverse effects ; chronic hepatitis C ; Disease Progression ; Drug Eruptions - etiology ; Female ; generalized pustular psoriasis ; Hepatitis C, Chronic - drug therapy ; Humans ; Interferon-alpha - adverse effects ; interferon-α ; Middle Aged ; Polyethylene Glycols - adverse effects ; Psoriasis - chemically induced ; Recombinant Proteins - adverse effects</subject><ispartof>Australasian journal of dermatology, 2012-11, Vol.53 (4), p.e69-e72</ispartof><rights>2011 The Authors. Australasian Journal of Dermatology © 2011 The Australasian College of Dermatologists</rights><rights>2011 The Authors. Australasian Journal of Dermatology © 2011 The Australasian College of Dermatologists.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3547-f37109650bd23d83d31b06bd70c8892b5118d36647654c370e0246bed4de90eb3</citedby><cites>FETCH-LOGICAL-c3547-f37109650bd23d83d31b06bd70c8892b5118d36647654c370e0246bed4de90eb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1440-0960.2011.00767.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1440-0960.2011.00767.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23157789$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wu, Meng-Chi</creatorcontrib><creatorcontrib>Lee, J Yu-Yun</creatorcontrib><title>Generalized flare of pustular psoriasis induced by PEGylated interferon-α2b therapy for chronic hepatitis C</title><title>Australasian journal of dermatology</title><addtitle>Australas J Dermatol</addtitle><description>ABSTRACT
New onset or exacerbation of psoriasis vulgaris has been reported in a small number of patients after interferon (IFN)‐α therapy. Herein, we report a case of generalized flare of pustular psoriasis induced by PEGylated IFN‐α2b (PEG‐IFN‐α2b) in a 59‐year‐old woman with a 15‐year history of pustular psoriasis and chronic hepatitis C. Interferon‐α therapy was discontinued and the rash resolved after treatment with cyclosporin and systemic methylprednisolone. The potential side effect of PEG‐IFN‐α2b in inducing or exacerbating psoriasis should be kept in mind when treating patients with a history of psoriasis or pustular psoriasis.</description><subject>Antiviral Agents - adverse effects</subject><subject>chronic hepatitis C</subject><subject>Disease Progression</subject><subject>Drug Eruptions - etiology</subject><subject>Female</subject><subject>generalized pustular psoriasis</subject><subject>Hepatitis C, Chronic - drug therapy</subject><subject>Humans</subject><subject>Interferon-alpha - adverse effects</subject><subject>interferon-α</subject><subject>Middle Aged</subject><subject>Polyethylene Glycols - adverse effects</subject><subject>Psoriasis - chemically induced</subject><subject>Recombinant Proteins - adverse effects</subject><issn>0004-8380</issn><issn>1440-0960</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkM9u1DAQxi1ERbeFV0A-ckkYx4ntSFyqpWxbrQCJvzcrjidaL9kk2InY9K14EZ6pXrbsGV_G4_m-b-QfIZRByuJ5vU1ZnkMCpYA0A8ZSAClkun9CFqfBU7IAgDxRXME5uQhhC8A4K4pn5DyLVUpVLki7wg591bp7tLRpK4-0b-gwhXGKDR1C710VXKCus1MdNWamH69Xc1uNsXHdiL5B33fJn9-ZoeMmZg0zbXpP6018djXd4FCNbowRy-fkrKnagC8e6yX58u768_ImWX9Y3S6v1knNi1wmDZcs_qAAYzNuFbecGRDGSqiVKjNTMKYsFyKXoshrLgEhy4VBm1ssAQ2_JK-OuYPvf04YRr1zoca2rTrsp6AZk0qIUvEsStVRWvs-BI-NHrzbVX7WDPSBtd7qA1J9QKoPrPVf1nofrS8ft0xmh_Zk_Ac3Ct4cBb9ci_N_B-uru7fxEu3J0e7CiPuTvfI_dJzKQn97v9J5odTXm--f9Jo_AOYXnM0</recordid><startdate>201211</startdate><enddate>201211</enddate><creator>Wu, Meng-Chi</creator><creator>Lee, J Yu-Yun</creator><general>Blackwell Publishing Asia</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201211</creationdate><title>Generalized flare of pustular psoriasis induced by PEGylated interferon-α2b therapy for chronic hepatitis C</title><author>Wu, Meng-Chi ; Lee, J Yu-Yun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3547-f37109650bd23d83d31b06bd70c8892b5118d36647654c370e0246bed4de90eb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Antiviral Agents - adverse effects</topic><topic>chronic hepatitis C</topic><topic>Disease Progression</topic><topic>Drug Eruptions - etiology</topic><topic>Female</topic><topic>generalized pustular psoriasis</topic><topic>Hepatitis C, Chronic - drug therapy</topic><topic>Humans</topic><topic>Interferon-alpha - adverse effects</topic><topic>interferon-α</topic><topic>Middle Aged</topic><topic>Polyethylene Glycols - adverse effects</topic><topic>Psoriasis - chemically induced</topic><topic>Recombinant Proteins - adverse effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wu, Meng-Chi</creatorcontrib><creatorcontrib>Lee, J Yu-Yun</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Australasian journal of dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wu, Meng-Chi</au><au>Lee, J Yu-Yun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Generalized flare of pustular psoriasis induced by PEGylated interferon-α2b therapy for chronic hepatitis C</atitle><jtitle>Australasian journal of dermatology</jtitle><addtitle>Australas J Dermatol</addtitle><date>2012-11</date><risdate>2012</risdate><volume>53</volume><issue>4</issue><spage>e69</spage><epage>e72</epage><pages>e69-e72</pages><issn>0004-8380</issn><eissn>1440-0960</eissn><abstract>ABSTRACT
New onset or exacerbation of psoriasis vulgaris has been reported in a small number of patients after interferon (IFN)‐α therapy. Herein, we report a case of generalized flare of pustular psoriasis induced by PEGylated IFN‐α2b (PEG‐IFN‐α2b) in a 59‐year‐old woman with a 15‐year history of pustular psoriasis and chronic hepatitis C. Interferon‐α therapy was discontinued and the rash resolved after treatment with cyclosporin and systemic methylprednisolone. The potential side effect of PEG‐IFN‐α2b in inducing or exacerbating psoriasis should be kept in mind when treating patients with a history of psoriasis or pustular psoriasis.</abstract><cop>Melbourne, Australia</cop><pub>Blackwell Publishing Asia</pub><pmid>23157789</pmid><doi>10.1111/j.1440-0960.2011.00767.x</doi><tpages>4</tpages></addata></record> |
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| ispartof | Australasian journal of dermatology, 2012-11, Vol.53 (4), p.e69-e72 |
| issn | 0004-8380 1440-0960 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Antiviral Agents - adverse effects chronic hepatitis C Disease Progression Drug Eruptions - etiology Female generalized pustular psoriasis Hepatitis C, Chronic - drug therapy Humans Interferon-alpha - adverse effects interferon-α Middle Aged Polyethylene Glycols - adverse effects Psoriasis - chemically induced Recombinant Proteins - adverse effects |
| title | Generalized flare of pustular psoriasis induced by PEGylated interferon-α2b therapy for chronic hepatitis C |
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