Decrease in central venous catheter placement due to use of ultrasound guidance for peripheral intravenous catheters
Abstract Study Objectives Obtaining intravenous (IV) access in the emergency department (ED) can be especially challenging, and physicians often resort to placement of central venous catheters (CVCs). Use of ultrasound-guided peripheral IV catheters (USGPIVs) can prevent many “unnecessary” CVCs, but...
Gespeichert in:
Veröffentlicht in: | The American journal of emergency medicine 2012-11, Vol.30 (9), p.1950-1954 |
---|---|
Hauptverfasser: | , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | 1954 |
---|---|
container_issue | 9 |
container_start_page | 1950 |
container_title | The American journal of emergency medicine |
container_volume | 30 |
creator | Au, Arthur K., MD Rotte, Masashi J., MD Grzybowski, Robert J Ku, Bon S., MD, MPP Fields, J. Matthew, MD |
description | Abstract Study Objectives Obtaining intravenous (IV) access in the emergency department (ED) can be especially challenging, and physicians often resort to placement of central venous catheters (CVCs). Use of ultrasound-guided peripheral IV catheters (USGPIVs) can prevent many “unnecessary” CVCs, but the true impact of USGPIVs has never been quantified. This study set out to determine the reduction in CVCs by USGPIV placement. Methods This was a prospective, observational study conducted in 2 urban EDs. Patients who were to undergo placement of a CVC due to inability to establish IV access by other methods were enrolled. Ultrasound-trained physicians then attempted USGPIV placement. Patients were followed up for up to 7 days to assess for CVC placement and related complications. Results One hundred patients were enrolled and underwent USGPIV placement. Ultrasound-guided peripheral IV catheters were initially successfully placed in all patients but failed in 12 patients (12.0%; 95 confidence interval [CI], 7.0%-19.8%) before ED disposition, resulting in 4 central lines, 7 repeated USGPIVs, and 1 patient requiring no further intervention. Through the inpatient follow-up period, another 11 patients underwent CVC placement, resulting in a total of 15 CVCs (15.0%; 95 CI, 9.3%-23.3%) placed. Of the 15 patients who did receive a CVC, 1 patient developed a catheter-related infection, resulting in a 6.7% (95 CI, 1.2%-29.8%) complication rate. Conclusion Ultrasound prevented the need for CVC placement in 85% of patients with difficult IV access. This suggests that USGPIVs have the potential to reduce morbidity in this patient population. |
doi_str_mv | 10.1016/j.ajem.2012.04.016 |
format | Article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1178667970</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S0735675712001805</els_id><sourcerecordid>2824671951</sourcerecordid><originalsourceid>FETCH-LOGICAL-c469t-5cf39369a17b0cc055403bc9e33a9fc8b218e4c574fbb30bd97f4be4a6de83713</originalsourceid><addsrcrecordid>eNp9kkuLFTEQhYMozp3RP-BCAiK46TbpvDogAzKODxhwoa5DOl3tpO3HNekemH9vNffqwF24ClS-c1KpU4S84KzkjOu3fel7GMuK8apkssTSI7LjSlRFzQ1_THbMCFVoo8wZOc-5Z4xzqeRTclZVxipb1zuyfICQwGegcaIBpiX5gd7BNK-ZBr_cwgKJ7gcfYMRL2q5Al5muyM8dXQfE87xOLf25xtZPAWg3Iw8p7m9hs4qb44lffkaedH7I8Px4XpAfH6-_X30ubr5--nL1_qYIUtulUKETVmjruWlYCEwpyUQTLAjhbRfqpuI1yKCM7JpGsKa1ppMNSK9bqIXh4oK8Ofju0_x7hby4MeYAw-AnwIYc56bW2ljDEH11gvbzmibsDilrtFCVNkhVByqkOecEndunOPp07zhzWyaud1smbsvEMemwhKKXR-u1GaH9J_kbAgKvj4DPwQ9dwkHG_MBpXTNmBXLvDhzgzO4iJJdDBBx6GxOExbVz_H8flyfyMMQp4ou_4B7yw39dRo37tm3Ptjy8wsWpmRJ_AMeawIE</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1197635267</pqid></control><display><type>article</type><title>Decrease in central venous catheter placement due to use of ultrasound guidance for peripheral intravenous catheters</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><source>ProQuest Central UK/Ireland</source><creator>Au, Arthur K., MD ; Rotte, Masashi J., MD ; Grzybowski, Robert J ; Ku, Bon S., MD, MPP ; Fields, J. Matthew, MD</creator><creatorcontrib>Au, Arthur K., MD ; Rotte, Masashi J., MD ; Grzybowski, Robert J ; Ku, Bon S., MD, MPP ; Fields, J. Matthew, MD</creatorcontrib><description>Abstract Study Objectives Obtaining intravenous (IV) access in the emergency department (ED) can be especially challenging, and physicians often resort to placement of central venous catheters (CVCs). Use of ultrasound-guided peripheral IV catheters (USGPIVs) can prevent many “unnecessary” CVCs, but the true impact of USGPIVs has never been quantified. This study set out to determine the reduction in CVCs by USGPIV placement. Methods This was a prospective, observational study conducted in 2 urban EDs. Patients who were to undergo placement of a CVC due to inability to establish IV access by other methods were enrolled. Ultrasound-trained physicians then attempted USGPIV placement. Patients were followed up for up to 7 days to assess for CVC placement and related complications. Results One hundred patients were enrolled and underwent USGPIV placement. Ultrasound-guided peripheral IV catheters were initially successfully placed in all patients but failed in 12 patients (12.0%; 95 confidence interval [CI], 7.0%-19.8%) before ED disposition, resulting in 4 central lines, 7 repeated USGPIVs, and 1 patient requiring no further intervention. Through the inpatient follow-up period, another 11 patients underwent CVC placement, resulting in a total of 15 CVCs (15.0%; 95 CI, 9.3%-23.3%) placed. Of the 15 patients who did receive a CVC, 1 patient developed a catheter-related infection, resulting in a 6.7% (95 CI, 1.2%-29.8%) complication rate. Conclusion Ultrasound prevented the need for CVC placement in 85% of patients with difficult IV access. This suggests that USGPIVs have the potential to reduce morbidity in this patient population.</description><identifier>ISSN: 0735-6757</identifier><identifier>EISSN: 1532-8171</identifier><identifier>DOI: 10.1016/j.ajem.2012.04.016</identifier><identifier>PMID: 22795988</identifier><identifier>CODEN: AJEMEN</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Biological and medical sciences ; Catheter-Related Infections - epidemiology ; Catheterization, Central Venous - adverse effects ; Catheterization, Central Venous - statistics & numerical data ; Catheterization, Peripheral - methods ; Catheterization, Peripheral - statistics & numerical data ; Catheters ; Emergency ; Emergency and intensive care: techniques, logistics ; Emergency medical care ; Emergency Service, Hospital - statistics & numerical data ; Humans ; Intensive care medicine ; Male ; Medical instruments ; Medical sciences ; Observational studies ; Patients ; Perfusions. Catheterizations. Hyperbaric oxygenotherapy ; Physicians ; Prospective Studies ; Treatment Failure ; Ultrasonic imaging ; Ultrasonography, Interventional - methods</subject><ispartof>The American journal of emergency medicine, 2012-11, Vol.30 (9), p.1950-1954</ispartof><rights>Elsevier Inc.</rights><rights>2012 Elsevier Inc.</rights><rights>2014 INIST-CNRS</rights><rights>Copyright © 2012 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c469t-5cf39369a17b0cc055403bc9e33a9fc8b218e4c574fbb30bd97f4be4a6de83713</citedby><cites>FETCH-LOGICAL-c469t-5cf39369a17b0cc055403bc9e33a9fc8b218e4c574fbb30bd97f4be4a6de83713</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1197635267?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,45974,64362,64364,64366,72216</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26680093$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22795988$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Au, Arthur K., MD</creatorcontrib><creatorcontrib>Rotte, Masashi J., MD</creatorcontrib><creatorcontrib>Grzybowski, Robert J</creatorcontrib><creatorcontrib>Ku, Bon S., MD, MPP</creatorcontrib><creatorcontrib>Fields, J. Matthew, MD</creatorcontrib><title>Decrease in central venous catheter placement due to use of ultrasound guidance for peripheral intravenous catheters</title><title>The American journal of emergency medicine</title><addtitle>Am J Emerg Med</addtitle><description>Abstract Study Objectives Obtaining intravenous (IV) access in the emergency department (ED) can be especially challenging, and physicians often resort to placement of central venous catheters (CVCs). Use of ultrasound-guided peripheral IV catheters (USGPIVs) can prevent many “unnecessary” CVCs, but the true impact of USGPIVs has never been quantified. This study set out to determine the reduction in CVCs by USGPIV placement. Methods This was a prospective, observational study conducted in 2 urban EDs. Patients who were to undergo placement of a CVC due to inability to establish IV access by other methods were enrolled. Ultrasound-trained physicians then attempted USGPIV placement. Patients were followed up for up to 7 days to assess for CVC placement and related complications. Results One hundred patients were enrolled and underwent USGPIV placement. Ultrasound-guided peripheral IV catheters were initially successfully placed in all patients but failed in 12 patients (12.0%; 95 confidence interval [CI], 7.0%-19.8%) before ED disposition, resulting in 4 central lines, 7 repeated USGPIVs, and 1 patient requiring no further intervention. Through the inpatient follow-up period, another 11 patients underwent CVC placement, resulting in a total of 15 CVCs (15.0%; 95 CI, 9.3%-23.3%) placed. Of the 15 patients who did receive a CVC, 1 patient developed a catheter-related infection, resulting in a 6.7% (95 CI, 1.2%-29.8%) complication rate. Conclusion Ultrasound prevented the need for CVC placement in 85% of patients with difficult IV access. This suggests that USGPIVs have the potential to reduce morbidity in this patient population.</description><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Biological and medical sciences</subject><subject>Catheter-Related Infections - epidemiology</subject><subject>Catheterization, Central Venous - adverse effects</subject><subject>Catheterization, Central Venous - statistics & numerical data</subject><subject>Catheterization, Peripheral - methods</subject><subject>Catheterization, Peripheral - statistics & numerical data</subject><subject>Catheters</subject><subject>Emergency</subject><subject>Emergency and intensive care: techniques, logistics</subject><subject>Emergency medical care</subject><subject>Emergency Service, Hospital - statistics & numerical data</subject><subject>Humans</subject><subject>Intensive care medicine</subject><subject>Male</subject><subject>Medical instruments</subject><subject>Medical sciences</subject><subject>Observational studies</subject><subject>Patients</subject><subject>Perfusions. Catheterizations. Hyperbaric oxygenotherapy</subject><subject>Physicians</subject><subject>Prospective Studies</subject><subject>Treatment Failure</subject><subject>Ultrasonic imaging</subject><subject>Ultrasonography, Interventional - methods</subject><issn>0735-6757</issn><issn>1532-8171</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kkuLFTEQhYMozp3RP-BCAiK46TbpvDogAzKODxhwoa5DOl3tpO3HNekemH9vNffqwF24ClS-c1KpU4S84KzkjOu3fel7GMuK8apkssTSI7LjSlRFzQ1_THbMCFVoo8wZOc-5Z4xzqeRTclZVxipb1zuyfICQwGegcaIBpiX5gd7BNK-ZBr_cwgKJ7gcfYMRL2q5Al5muyM8dXQfE87xOLf25xtZPAWg3Iw8p7m9hs4qb44lffkaedH7I8Px4XpAfH6-_X30ubr5--nL1_qYIUtulUKETVmjruWlYCEwpyUQTLAjhbRfqpuI1yKCM7JpGsKa1ppMNSK9bqIXh4oK8Ofju0_x7hby4MeYAw-AnwIYc56bW2ljDEH11gvbzmibsDilrtFCVNkhVByqkOecEndunOPp07zhzWyaud1smbsvEMemwhKKXR-u1GaH9J_kbAgKvj4DPwQ9dwkHG_MBpXTNmBXLvDhzgzO4iJJdDBBx6GxOExbVz_H8flyfyMMQp4ou_4B7yw39dRo37tm3Ptjy8wsWpmRJ_AMeawIE</recordid><startdate>20121101</startdate><enddate>20121101</enddate><creator>Au, Arthur K., MD</creator><creator>Rotte, Masashi J., MD</creator><creator>Grzybowski, Robert J</creator><creator>Ku, Bon S., MD, MPP</creator><creator>Fields, J. Matthew, MD</creator><general>Elsevier Inc</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20121101</creationdate><title>Decrease in central venous catheter placement due to use of ultrasound guidance for peripheral intravenous catheters</title><author>Au, Arthur K., MD ; Rotte, Masashi J., MD ; Grzybowski, Robert J ; Ku, Bon S., MD, MPP ; Fields, J. Matthew, MD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c469t-5cf39369a17b0cc055403bc9e33a9fc8b218e4c574fbb30bd97f4be4a6de83713</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Biological and medical sciences</topic><topic>Catheter-Related Infections - epidemiology</topic><topic>Catheterization, Central Venous - adverse effects</topic><topic>Catheterization, Central Venous - statistics & numerical data</topic><topic>Catheterization, Peripheral - methods</topic><topic>Catheterization, Peripheral - statistics & numerical data</topic><topic>Catheters</topic><topic>Emergency</topic><topic>Emergency and intensive care: techniques, logistics</topic><topic>Emergency medical care</topic><topic>Emergency Service, Hospital - statistics & numerical data</topic><topic>Humans</topic><topic>Intensive care medicine</topic><topic>Male</topic><topic>Medical instruments</topic><topic>Medical sciences</topic><topic>Observational studies</topic><topic>Patients</topic><topic>Perfusions. Catheterizations. Hyperbaric oxygenotherapy</topic><topic>Physicians</topic><topic>Prospective Studies</topic><topic>Treatment Failure</topic><topic>Ultrasonic imaging</topic><topic>Ultrasonography, Interventional - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Au, Arthur K., MD</creatorcontrib><creatorcontrib>Rotte, Masashi J., MD</creatorcontrib><creatorcontrib>Grzybowski, Robert J</creatorcontrib><creatorcontrib>Ku, Bon S., MD, MPP</creatorcontrib><creatorcontrib>Fields, J. Matthew, MD</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of emergency medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Au, Arthur K., MD</au><au>Rotte, Masashi J., MD</au><au>Grzybowski, Robert J</au><au>Ku, Bon S., MD, MPP</au><au>Fields, J. Matthew, MD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Decrease in central venous catheter placement due to use of ultrasound guidance for peripheral intravenous catheters</atitle><jtitle>The American journal of emergency medicine</jtitle><addtitle>Am J Emerg Med</addtitle><date>2012-11-01</date><risdate>2012</risdate><volume>30</volume><issue>9</issue><spage>1950</spage><epage>1954</epage><pages>1950-1954</pages><issn>0735-6757</issn><eissn>1532-8171</eissn><coden>AJEMEN</coden><abstract>Abstract Study Objectives Obtaining intravenous (IV) access in the emergency department (ED) can be especially challenging, and physicians often resort to placement of central venous catheters (CVCs). Use of ultrasound-guided peripheral IV catheters (USGPIVs) can prevent many “unnecessary” CVCs, but the true impact of USGPIVs has never been quantified. This study set out to determine the reduction in CVCs by USGPIV placement. Methods This was a prospective, observational study conducted in 2 urban EDs. Patients who were to undergo placement of a CVC due to inability to establish IV access by other methods were enrolled. Ultrasound-trained physicians then attempted USGPIV placement. Patients were followed up for up to 7 days to assess for CVC placement and related complications. Results One hundred patients were enrolled and underwent USGPIV placement. Ultrasound-guided peripheral IV catheters were initially successfully placed in all patients but failed in 12 patients (12.0%; 95 confidence interval [CI], 7.0%-19.8%) before ED disposition, resulting in 4 central lines, 7 repeated USGPIVs, and 1 patient requiring no further intervention. Through the inpatient follow-up period, another 11 patients underwent CVC placement, resulting in a total of 15 CVCs (15.0%; 95 CI, 9.3%-23.3%) placed. Of the 15 patients who did receive a CVC, 1 patient developed a catheter-related infection, resulting in a 6.7% (95 CI, 1.2%-29.8%) complication rate. Conclusion Ultrasound prevented the need for CVC placement in 85% of patients with difficult IV access. This suggests that USGPIVs have the potential to reduce morbidity in this patient population.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>22795988</pmid><doi>10.1016/j.ajem.2012.04.016</doi><tpages>5</tpages></addata></record> |
fulltext | fulltext |
identifier | ISSN: 0735-6757 |
ispartof | The American journal of emergency medicine, 2012-11, Vol.30 (9), p.1950-1954 |
issn | 0735-6757 1532-8171 |
language | eng |
recordid | cdi_proquest_miscellaneous_1178667970 |
source | MEDLINE; Elsevier ScienceDirect Journals; ProQuest Central UK/Ireland |
subjects | Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Catheter-Related Infections - epidemiology Catheterization, Central Venous - adverse effects Catheterization, Central Venous - statistics & numerical data Catheterization, Peripheral - methods Catheterization, Peripheral - statistics & numerical data Catheters Emergency Emergency and intensive care: techniques, logistics Emergency medical care Emergency Service, Hospital - statistics & numerical data Humans Intensive care medicine Male Medical instruments Medical sciences Observational studies Patients Perfusions. Catheterizations. Hyperbaric oxygenotherapy Physicians Prospective Studies Treatment Failure Ultrasonic imaging Ultrasonography, Interventional - methods |
title | Decrease in central venous catheter placement due to use of ultrasound guidance for peripheral intravenous catheters |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-22T11%3A08%3A54IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Decrease%20in%20central%20venous%20catheter%20placement%20due%20to%20use%20of%20ultrasound%20guidance%20for%20peripheral%20intravenous%20catheters&rft.jtitle=The%20American%20journal%20of%20emergency%20medicine&rft.au=Au,%20Arthur%20K.,%20MD&rft.date=2012-11-01&rft.volume=30&rft.issue=9&rft.spage=1950&rft.epage=1954&rft.pages=1950-1954&rft.issn=0735-6757&rft.eissn=1532-8171&rft.coden=AJEMEN&rft_id=info:doi/10.1016/j.ajem.2012.04.016&rft_dat=%3Cproquest_cross%3E2824671951%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1197635267&rft_id=info:pmid/22795988&rft_els_id=1_s2_0_S0735675712001805&rfr_iscdi=true |