TGF-β Signaling, Activated Stromal Fibroblasts, and Cysteine Cathepsins B and L Drive the Invasive Growth of Human Melanoma Cells

Accumulating evidence indicates that interactions between cancer cells and stromal cells are important for the development/progression of many cancers. Herein, we found that the invasive growth of melanoma cells in three-dimensional–Matrigel/collagen-I matrices is dramatically increased on their co-...

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Veröffentlicht in:	The American journal of pathology 2012-12, Vol.181 (6), p.2202-2216
Hauptverfasser:	Yin, Miao, Soikkeli, Johanna, Jahkola, Tiina, Virolainen, Susanna, Saksela, Olli, Hölttä, Erkki
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Biological and medical sciences Cathepsin B - antagonists & inhibitors Cathepsin B - metabolism Cathepsin L - antagonists & inhibitors Cathepsin L - metabolism Cell Line, Tumor Cell Proliferation - drug effects Dermatology Embryo, Mammalian - pathology Fibroblasts - drug effects Fibroblasts - enzymology Fibroblasts - pathology Fluorescent Dyes - metabolism Gene Expression Profiling Gene Expression Regulation, Neoplastic - drug effects Humans Investigative techniques, diagnostic techniques (general aspects) Matrix Metalloproteinases - metabolism Medical sciences Melanoma - enzymology Melanoma - genetics Melanoma - pathology Neoplasm Invasiveness Nevus - enzymology Nevus - pathology Oligonucleotide Array Sequence Analysis Pathology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Protease Inhibitors - pharmacology Protein-Serine-Threonine Kinases - antagonists & inhibitors Protein-Serine-Threonine Kinases - metabolism Receptor, Transforming Growth Factor-beta Type I Receptors, Transforming Growth Factor beta - antagonists & inhibitors Receptors, Transforming Growth Factor beta - metabolism Signal Transduction - drug effects Signal Transduction - genetics Skin - pathology Skin Neoplasms - enzymology Skin Neoplasms - genetics Skin Neoplasms - pathology Stromal Cells - drug effects Stromal Cells - enzymology Stromal Cells - pathology Transforming Growth Factor beta - metabolism Tumors of the skin and soft tissue. Premalignant lesions
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