Mucormycosis of the head and neck
Abstract Introduction Mucormycosis of the head and neck is a rare disease increasingly occurring in immunocompromised patients. We report on two cases with different outcomes. Case reports A 63-year-old female presented with a recently developed deformation of her right cheek and nose combined with...
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| Veröffentlicht in: | Journal of cranio-maxillo-facial surgery 2012-12, Vol.40 (8), p.e321-e327 |
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| container_issue | 8 |
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| container_title | Journal of cranio-maxillo-facial surgery |
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| creator | Metzen, Daniela Böhm, Hartmut Zimmermann, Marc Reuther, Tobias Kübler, Alexander C Müller-Richter, Urs D.A |
| description | Abstract Introduction Mucormycosis of the head and neck is a rare disease increasingly occurring in immunocompromised patients. We report on two cases with different outcomes. Case reports A 63-year-old female presented with a recently developed deformation of her right cheek and nose combined with a loosening of the teeth. Further examination revealed mucormycosis of the maxilla. Hemimaxillectomy and secondary bony reconstruction with oral rehabilitation were performed. The second patient was a 54-year-old male who suffered from multiple myeloma. After receiving an allogeneic haematopoietic stem cell transplant, he developed a necrotizing infection of the right midface. Histopathological investigation confirmed the diagnosis of mucormycosis. The patient died one day after radical surgical resection. Discussion These two cases demonstrate the variability of mucormycosis. Although slow progression of the disease is possible, a high level of attentiveness and expedient treatment are necessary due to the high risk of a devastating course. |
| doi_str_mv | 10.1016/j.jcms.2012.01.015 |
| format | Article |
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We report on two cases with different outcomes. Case reports A 63-year-old female presented with a recently developed deformation of her right cheek and nose combined with a loosening of the teeth. Further examination revealed mucormycosis of the maxilla. Hemimaxillectomy and secondary bony reconstruction with oral rehabilitation were performed. The second patient was a 54-year-old male who suffered from multiple myeloma. After receiving an allogeneic haematopoietic stem cell transplant, he developed a necrotizing infection of the right midface. Histopathological investigation confirmed the diagnosis of mucormycosis. The patient died one day after radical surgical resection. Discussion These two cases demonstrate the variability of mucormycosis. 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All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c444t-5db386ed7603180449846d3417a91cd67e7731279e06d865561c53a767fcf5c53</citedby><cites>FETCH-LOGICAL-c444t-5db386ed7603180449846d3417a91cd67e7731279e06d865561c53a767fcf5c53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1010518212000297$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22425500$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Metzen, Daniela</creatorcontrib><creatorcontrib>Böhm, Hartmut</creatorcontrib><creatorcontrib>Zimmermann, Marc</creatorcontrib><creatorcontrib>Reuther, Tobias</creatorcontrib><creatorcontrib>Kübler, Alexander C</creatorcontrib><creatorcontrib>Müller-Richter, Urs D.A</creatorcontrib><title>Mucormycosis of the head and neck</title><title>Journal of cranio-maxillo-facial surgery</title><addtitle>J Craniomaxillofac Surg</addtitle><description>Abstract Introduction Mucormycosis of the head and neck is a rare disease increasingly occurring in immunocompromised patients. We report on two cases with different outcomes. Case reports A 63-year-old female presented with a recently developed deformation of her right cheek and nose combined with a loosening of the teeth. Further examination revealed mucormycosis of the maxilla. Hemimaxillectomy and secondary bony reconstruction with oral rehabilitation were performed. The second patient was a 54-year-old male who suffered from multiple myeloma. After receiving an allogeneic haematopoietic stem cell transplant, he developed a necrotizing infection of the right midface. Histopathological investigation confirmed the diagnosis of mucormycosis. The patient died one day after radical surgical resection. Discussion These two cases demonstrate the variability of mucormycosis. Although slow progression of the disease is possible, a high level of attentiveness and expedient treatment are necessary due to the high risk of a devastating course.</description><subject>Dentistry</subject><subject>Dermatomycoses - diagnosis</subject><subject>Facial Dermatoses - microbiology</subject><subject>Fatal Outcome</subject><subject>Female</subject><subject>Head</subject><subject>Hematopoietic Stem Cell Transplantation</subject><subject>Humans</subject><subject>Immunocompromised Host</subject><subject>Infection</subject><subject>Lymphoma, B-Cell - drug therapy</subject><subject>Male</subject><subject>Maxillary Diseases - microbiology</subject><subject>Middle Aged</subject><subject>Mucormycosis</subject><subject>Mucormycosis - diagnosis</subject><subject>Multiple Myeloma - surgery</subject><subject>Nasal Septum - microbiology</subject><subject>Necrosis</subject><subject>Nose Diseases - microbiology</subject><subject>Reconstructive Surgical Procedures - methods</subject><subject>Surgery</subject><issn>1010-5182</issn><issn>1878-4119</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kUtr3EAQhIcQ41f8B3Iwys0XbbpH8xKEQDC2E7DJwc550M608Mh62DOrwP77jNi1Dz4EGroPVQX9FWOfEVYIqL52q84NacUB-Qowj_zAjtFoUwrE-mO-AaGUaPgRO0mpAwAFpj5kR5wLLiXAMftyN7spDls3pZCKqS02j1Q8UuOLZvTFSO7pEztomz7R2X6fsj_XVw-XP8vb3ze_Ln_clk4IsSmlX1dGkdcKKjQgRG2E8pVA3dTovNKkdYVc1wTKGyWlQierRivdulbm85Rd7HKf4_QyU9rYISRHfd-MNM3JImqjlJJcZCnfSV2cUorU2ucYhiZuLYJd0NjOLmjsgsYC5lnyz_f583og_2Z5ZZEF33YCyl_-DRRtcoFGRz5Echvrp_D__O_v7K4PY3BN_0RbSt00xzHzs2hT9tj7pZylG-S5F17r6h9_MIXy</recordid><startdate>20121201</startdate><enddate>20121201</enddate><creator>Metzen, Daniela</creator><creator>Böhm, Hartmut</creator><creator>Zimmermann, Marc</creator><creator>Reuther, Tobias</creator><creator>Kübler, Alexander C</creator><creator>Müller-Richter, Urs D.A</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20121201</creationdate><title>Mucormycosis of the head and neck</title><author>Metzen, Daniela ; Böhm, Hartmut ; Zimmermann, Marc ; Reuther, Tobias ; Kübler, Alexander C ; Müller-Richter, Urs D.A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c444t-5db386ed7603180449846d3417a91cd67e7731279e06d865561c53a767fcf5c53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Dentistry</topic><topic>Dermatomycoses - diagnosis</topic><topic>Facial Dermatoses - microbiology</topic><topic>Fatal Outcome</topic><topic>Female</topic><topic>Head</topic><topic>Hematopoietic Stem Cell Transplantation</topic><topic>Humans</topic><topic>Immunocompromised Host</topic><topic>Infection</topic><topic>Lymphoma, B-Cell - drug therapy</topic><topic>Male</topic><topic>Maxillary Diseases - microbiology</topic><topic>Middle Aged</topic><topic>Mucormycosis</topic><topic>Mucormycosis - diagnosis</topic><topic>Multiple Myeloma - surgery</topic><topic>Nasal Septum - microbiology</topic><topic>Necrosis</topic><topic>Nose Diseases - microbiology</topic><topic>Reconstructive Surgical Procedures - methods</topic><topic>Surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Metzen, Daniela</creatorcontrib><creatorcontrib>Böhm, Hartmut</creatorcontrib><creatorcontrib>Zimmermann, Marc</creatorcontrib><creatorcontrib>Reuther, Tobias</creatorcontrib><creatorcontrib>Kübler, Alexander C</creatorcontrib><creatorcontrib>Müller-Richter, Urs D.A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cranio-maxillo-facial surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Metzen, Daniela</au><au>Böhm, Hartmut</au><au>Zimmermann, Marc</au><au>Reuther, Tobias</au><au>Kübler, Alexander C</au><au>Müller-Richter, Urs D.A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mucormycosis of the head and neck</atitle><jtitle>Journal of cranio-maxillo-facial surgery</jtitle><addtitle>J Craniomaxillofac Surg</addtitle><date>2012-12-01</date><risdate>2012</risdate><volume>40</volume><issue>8</issue><spage>e321</spage><epage>e327</epage><pages>e321-e327</pages><issn>1010-5182</issn><eissn>1878-4119</eissn><abstract>Abstract Introduction Mucormycosis of the head and neck is a rare disease increasingly occurring in immunocompromised patients. We report on two cases with different outcomes. Case reports A 63-year-old female presented with a recently developed deformation of her right cheek and nose combined with a loosening of the teeth. Further examination revealed mucormycosis of the maxilla. Hemimaxillectomy and secondary bony reconstruction with oral rehabilitation were performed. The second patient was a 54-year-old male who suffered from multiple myeloma. After receiving an allogeneic haematopoietic stem cell transplant, he developed a necrotizing infection of the right midface. Histopathological investigation confirmed the diagnosis of mucormycosis. The patient died one day after radical surgical resection. Discussion These two cases demonstrate the variability of mucormycosis. Although slow progression of the disease is possible, a high level of attentiveness and expedient treatment are necessary due to the high risk of a devastating course.</abstract><cop>Scotland</cop><pub>Elsevier Ltd</pub><pmid>22425500</pmid><doi>10.1016/j.jcms.2012.01.015</doi></addata></record> |
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| subjects | Dentistry Dermatomycoses - diagnosis Facial Dermatoses - microbiology Fatal Outcome Female Head Hematopoietic Stem Cell Transplantation Humans Immunocompromised Host Infection Lymphoma, B-Cell - drug therapy Male Maxillary Diseases - microbiology Middle Aged Mucormycosis Mucormycosis - diagnosis Multiple Myeloma - surgery Nasal Septum - microbiology Necrosis Nose Diseases - microbiology Reconstructive Surgical Procedures - methods Surgery |
| title | Mucormycosis of the head and neck |
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