5-aza-CdR induces the demethylation of Syk promoter in nasopharyngeal carcinoma cell

The present study employed 5-aza-2′-deoxycytidine (5-aza-CdR) to treat nasopharyngeal carcinoma cell line CNE-1, CNE-2 and non-cancerous human nasopharyngeal epithelial cell line NP-69 to understand the effects on spleen tyrosine kinase (Syk) gene promoter methylation. The results showed that the me...

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Veröffentlicht in:	Gene 2012-12, Vol.511 (2), p.224-226
Hauptverfasser:	Jin, Qiaozhi, Liu, Chibo, Yan, Chong, Tao, Baohong, Li, Zhihai, Cai, Zhiyi
Format:	Artikel
Sprache:	eng
Schlagworte:	5-aza-2'-deoxycytidine 5-aza-CdR Antimetabolites, Antineoplastic - pharmacology Azacitidine - analogs & derivatives Azacitidine - pharmacology Base Sequence Blotting, Western carcinoma cell differentiation Cell Line, Tumor Demethylation Differentiation DNA Methylation DNA Primers Drugs Epithelial cells genes Humans Intracellular Signaling Peptides and Proteins - genetics methylation Nasopharyngeal carcinoma Nasopharyngeal Neoplasms - genetics Nasopharyngeal Neoplasms - pathology Promoter Regions, Genetic Promoters Protein-tyrosine kinase Protein-Tyrosine Kinases - genetics Real-Time Polymerase Chain Reaction RNA, Messenger - genetics Spleen Syk Syk Kinase Syk protein Tumor cell lines
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