Comparison of protein, microRNA, and mRNA yields using different methods of urinary exosome isolation for the discovery of kidney disease biomarkers

Urinary exosomes are 40–100nm vesicles containing protein, mRNA, and microRNA that may serve as biomarkers of renal dysfunction and structural injury. Currently, there is a need for more sensitive and specific biomarkers of renal injury and disease progression. Here we sought to identify the best ex...

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Veröffentlicht in:	Kidney international 2012-11, Vol.82 (9), p.1024-1032
Hauptverfasser:	Alvarez, M. Lucrecia, Khosroheidari, Mahdieh, Kanchi Ravi, Rupesh, DiStefano, Johanna K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Associated diseases and complications Biological and medical sciences biomarkers Biomarkers - urine chronic kidney disease Diabetes. Impaired glucose tolerance Diabetic Nephropathies - diagnosis Diabetic Nephropathies - genetics Diabetic Nephropathies - urine diabetic nephropathy Electrophoresis - methods Endocrine pancreas. Apud cells (diseases) Endocrinopathies exosome Exosome Multienzyme Ribonuclease Complex - genetics Exosome Multienzyme Ribonuclease Complex - isolation & purification Exosome Multienzyme Ribonuclease Complex - urine exosomes Genetic Testing - methods Humans Injuries Kidney diseases Kidneys Medical sciences MicroRNAs - genetics MicroRNAs - isolation & purification MicroRNAs - urine miRNA mRNA Nephrology. Urinary tract diseases Precipitation proteomics Proteomics - methods Renal function Renal Insufficiency, Chronic - diagnosis Renal Insufficiency, Chronic - genetics Renal Insufficiency, Chronic - urine RNA, Messenger - genetics RNA, Messenger - isolation & purification RNA, Messenger - urine Ultracentrifugation Ultracentrifugation - methods Urinary system involvement in other diseases. Miscellaneous Urine Uromodulin - urine Vesicles
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