Electrochemical and spectroscopic studies of the interaction between the neuroleptic drug, gabapentin, and DNA

► The interaction of the neuroleptic drug, gabapentin, and DNA is investigated for the first time. ► Several analytical methods are used in the study of interaction which their results are comparable. ► The interaction between gabapentin and DNA occurs through electrostatic and groove binding modes....

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Veröffentlicht in:	Journal of pharmaceutical and biomedical analysis 2012-11, Vol.70, p.598-601
Hauptverfasser:	Jalali, Fahimeh, Dorraji, Parisa S.
Format:	Artikel
Sprache:	eng
Schlagworte:	absorption Amines - chemistry Amines - metabolism Analysis Analytical, structural and metabolic biochemistry Antipsychotic Agents - chemistry Antipsychotic Agents - metabolism antipsychotics Binding constant Biological and medical sciences C.D Circular Dichroism Cyclic voltammetry Cyclohexanecarboxylic Acids - chemistry Cyclohexanecarboxylic Acids - metabolism DNA DNA - chemistry DNA - metabolism Drugs Electrochemical Techniques electrochemistry electrostatic interactions Electrostatic properties Fluorescence fluorescence emission spectroscopy Free energy Fundamental and applied biological sciences. Psychology Gabapentin gamma-Aminobutyric Acid - chemistry gamma-Aminobutyric Acid - metabolism General pharmacology Gibbs free energy Intercalating Agents - chemistry Intercalating Agents - metabolism Medical sciences Neuroleptics Oxidation Oxidation-Reduction Pharmacology. Drug treatments Spectrometry, Fluorescence Spectrophotometry Spectrophotometry, Ultraviolet Spectroscopy Static Electricity
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