Kinetics of serum brain-derived neurotrophic factor following low-intensity versus high-intensity exercise in men and women
Physical activity has been shown to enhance circulating brain-derived neurotrophic factor (BDNF) in animals and humans. However, the exact time course and sex-specific modulation of peripheral BDNF in response to exercise are still poorly understood. We examined the kinetics of BDNF serum concentrat...
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| Veröffentlicht in: | Neuroreport 2012-10, Vol.23 (15), p.889-893 |
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| creator | Schmidt-Kassow, Maren Schädle, Sarah Otterbein, Sascha Thiel, Christian Doehring, Alexandra Lötsch, Jörn Kaiser, Jochen |
| description | Physical activity has been shown to enhance circulating brain-derived neurotrophic factor (BDNF) in animals and humans. However, the exact time course and sex-specific modulation of peripheral BDNF in response to exercise are still poorly understood. We examined the kinetics of BDNF serum concentrations in response to perceived high-intensity and low-intensity exercise, and during a subsequent recovery period by taking several blood samples during each phase. Furthermore, we compared the BDNF concentration between young men and women taking oral contraceptives. We found transient BDNF elevations during physical activity only for the high-intensity condition. Here, BDNF reached its maximum serum concentration after 20 min of exercise, and returned to baseline after approximately 10 min of recovery. Although there were no sex differences during baselineor recovery, the increase in the BDNF concentration during the exercise phase was more pronounced in men than in women. |
| doi_str_mv | 10.1097/WNR.0b013e32835946ca |
| format | Article |
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However, the exact time course and sex-specific modulation of peripheral BDNF in response to exercise are still poorly understood. We examined the kinetics of BDNF serum concentrations in response to perceived high-intensity and low-intensity exercise, and during a subsequent recovery period by taking several blood samples during each phase. Furthermore, we compared the BDNF concentration between young men and women taking oral contraceptives. We found transient BDNF elevations during physical activity only for the high-intensity condition. Here, BDNF reached its maximum serum concentration after 20 min of exercise, and returned to baseline after approximately 10 min of recovery. 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Although there were no sex differences during baselineor recovery, the increase in the BDNF concentration during the exercise phase was more pronounced in men than in women.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Brain-Derived Neurotrophic Factor - blood</subject><subject>Contraceptives, Oral, Hormonal - administration & dosage</subject><subject>Exercise - physiology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Male</subject><subject>Sex Characteristics</subject><subject>Sex Factors</subject><subject>Surveys and Questionnaires</subject><subject>Vertebrates: body movement. Posture. Locomotion. Flight. Swimming. Physical exercise. Rest. 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| subjects | Adult Biological and medical sciences Brain-Derived Neurotrophic Factor - blood Contraceptives, Oral, Hormonal - administration & dosage Exercise - physiology Female Fundamental and applied biological sciences. Psychology Humans Male Sex Characteristics Sex Factors Surveys and Questionnaires Vertebrates: body movement. Posture. Locomotion. Flight. Swimming. Physical exercise. Rest. Sports |
| title | Kinetics of serum brain-derived neurotrophic factor following low-intensity versus high-intensity exercise in men and women |
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