Periodontal Pathogen Aggregatibacter actinomycetemcomitans Deteriorates Pressure Overload-Induced Myocardial Hypertrophy in Mice

Although a relationship between periodontitis and myocardial hypertrophy has been reported, the precise mechanism has not been clarified. The purpose of this study was to investigate the association between periodontal infection and myocardial hypertrophy. Transverse aortic constriction (TAC) was pe...

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Veröffentlicht in:	International Heart Journal 2012, Vol.53(5), pp.324-330
Hauptverfasser:	Sekinishi, Asuka, Suzuki, Jun-ichi, Aoyama, Norio, Ogawa, Masahito, Watanabe, Ryo, Kobayashi, Naho, Hanatani, Tomoya, Ashigaki, Norihiko, Hirata, Yasunobu, Nagai, Ryozo, Izumi, Yuichi, Isobe, Mitsuaki
Format:	Artikel
Sprache:	eng
Schlagworte:	Actinobacillus Infections - physiopathology Aggregatibacter actinomycetemcomitans - pathogenicity Animals Antibodies, Bacterial - blood Aorta Arteriosclerosis Arteriosclerosis - etiology Bacteria Body weight Cardiomegaly - enzymology Cardiomegaly - physiopathology Colony-forming cells Echocardiography Fibrosis Fibrosis - etiology Gelatinase A Gene Expression Heart Heart Ventricles - pathology Hypertrophy Immunohistochemistry Infection Male Matrix Metalloproteinases - genetics Matrix Metalloproteinases - metabolism Mice Mice, Inbred C57BL Myocardium - pathology Organ Size Pathogens Periodontal Diseases - microbiology Periodontitis Pressure Reverse Transcriptase Polymerase Chain Reaction Ventricle Ventricular remodeling
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