Rapid quantification of protein–polyethylene glycol conjugates by multivariate evaluation of chromatographic data

► High throughput analytics approach for protein PEGamers successfully demonstrated. ► Low analysis time for SEC based quantification of protein PEGamers of 2min. ► Multivariate calibration compensates resolution sacrificed to gain analytical speed. Size exclusion chromatography (SEC) is often appli...

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Veröffentlicht in:	Journal of Chromatography A 2012-09, Vol.1257, p.41-47
Hauptverfasser:	Hansen, Sigrid K., Maiser, Benjamin, Hubbuch, Jürgen
Format:	Artikel
Sprache:	eng
Schlagworte:	Calibration Chromatography, Gel - methods equipment performance gel chromatography High throughput analytics High throughput experimentation High throughput process development High-Throughput Screening Assays - methods Multivariate Analysis Multivariate calibration PEGamer quantification polyethylene glycol Polyethylene Glycols - analysis Polyethylene Glycols - chemistry Protein PEGylation proteins Proteins - analysis Proteins - chemistry Regression Analysis Sensitivity and Specificity
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