BLT1-dependent Alveolar Recruitment of CD4+CD25+ Foxp3+ Regulatory T Cells Is Important for Resolution of Acute Lung Injury

Recent study has demonstrated that CD4(+)CD25(+)Foxp3(+) regulatory T cells (Tregs) present in bronchoalveolar lavage fluid (BALF) contribute to the resolution of an experimental acute lung injury (ALI). However, the molecular mechanism underlying the alveolar recruitment of Treg remains unclear. To...

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Veröffentlicht in:	American journal of respiratory and critical care medicine 2012-11, Vol.186 (10), p.989-998
Hauptverfasser:	Wang, Luman, Zhao, Lina, Lv, Jiaoyan, Yin, Qili, Liang, Xiaoyu, Chu, Yiwei, He, Rui
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Lung Injury - immunology Adoptive Transfer Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Biological and medical sciences Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis Bronchoalveolar Lavage Fluid - cytology Bronchoalveolar Lavage Fluid - immunology Cells, Cultured Chemotaxis Forkhead Transcription Factors - metabolism Humans Intensive care medicine Leukotriene B4 - immunology Medical sciences Mice Mice, Inbred C57BL Pulmonary Alveoli - immunology Receptors, Leukotriene B4 - antagonists & inhibitors Receptors, Leukotriene B4 - immunology Receptors, Leukotriene B4 - metabolism T-Lymphocytes, Regulatory - immunology Transfusions. Complications. Transfusion reactions. Cell and gene therapy Up-Regulation
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