Epigenetic mechanisms regulate the prostaglandin E receptor 2 in breast cancer

► We examine epigenetic mechanisms regulating the EP2 receptor in ER+ breast cancer. ► EP2 mRNA levels are increased when DNA methylation and histone deacetylation are inhibited in breast cancer cell lines. ► Inhibition of DNA methylation increases EP2 mRNA levels in breast adipose fibroblasts. ► EP...

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Veröffentlicht in:	The Journal of steroid biochemistry and molecular biology 2012-11, Vol.132 (3-5), p.331-338
Hauptverfasser:	To, Sarah Q., Takagi, Kiyoshi, Miki, Yasuhiro, Suzuki, Koyu, Abe, Eriko, Yang, Yang, Sasano, Hironobu, Simpson, Evan R., Knower, Kevin C., Clyne, Colin D.
Format:	Artikel
Sprache:	eng
Schlagworte:	5-aza-2'-deoxycytidine Adipose Tissue - cytology Aromatase Azacitidine - analogs & derivatives Azacitidine - pharmacology Breast cancer Breast Neoplasms - genetics Breast Neoplasms - pathology Carcinoma Carcinoma, Intraductal, Noninfiltrating - genetics Carcinoma, Intraductal, Noninfiltrating - pathology Cell Line, Tumor CpG Islands Deacetylation DNA Methylation Enzymes EP2 Epigenesis, Genetic Epigenetics Estrogen receptors Female Fibroblasts Fibroblasts - metabolism Gene Expression Regulation, Neoplastic Histone Deacetylase Inhibitors - pharmacology Histones Histones - metabolism Humans Hydroxamic Acids - pharmacology Invasiveness mRNA Promoter Regions, Genetic Promoters prostaglandin E receptors Prostaglandin E2 prostaglandin receptors Receptors, Prostaglandin E, EP2 Subtype - genetics Receptors, Prostaglandin E, EP2 Subtype - metabolism Reference Values Sodium Steroid hormones Stroma Stromal Cells - metabolism Trichostatin A Tumor cell lines
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