Lung function decline and blood lead among residents nearby to industrial complex
Purpose This study was to ascertain the risk factors of pulmonary function decline (forced expiratory volume in 1 s [FEV 1 ], forced vital capacity [FVC]) among those exposed to lead in the vicinity of industrial complex. Methods In total, 263 men and women, aged over 30, were recruited from two cit...
Gespeichert in:
| Veröffentlicht in: | International archives of occupational and environmental health 2012-11, Vol.85 (8), p.951-959 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 959 |
|---|---|
| container_issue | 8 |
| container_start_page | 951 |
| container_title | International archives of occupational and environmental health |
| container_volume | 85 |
| creator | Pak, Yun-Suk Oh, Aeri Kho, Young Lim Paek, Domyung |
| description | Purpose
This study was to ascertain the risk factors of pulmonary function decline (forced expiratory volume in 1 s [FEV
1
], forced vital capacity [FVC]) among those exposed to lead in the vicinity of industrial complex.
Methods
In total, 263 men and women, aged over 30, were recruited from two cities during a 2-year follow-up. Spirometry testing was conducted first at baseline and then after 2-years of follow-up. The change in FVC and FEV
1
during the study period was analyzed according to blood lead (BPb), urinary cotinine, and 1-hydroxypyrene, after controlling for sex, height, baseline FVC or FEV
1
, and airway hyperresponsiveness.
Results
With increase in age, both FEV
1
and FVC declined. More marked decline in FVC was noted for men than for women (
p
|
| doi_str_mv | 10.1007/s00420-012-0743-y |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1171874222</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1171874222</sourcerecordid><originalsourceid>FETCH-LOGICAL-c435t-14c80e7fd8e461f3c0b8f40e82227249daf989c7d68d1756ed5ba270f8c006713</originalsourceid><addsrcrecordid>eNp10E2LFDEQBuAgijuu_gAvEhDBS2tVOt1JH2XxCwZE0HOTTipLL-lkTLrB-febYcYPBE851FNvipex5whvEEC9LQBSQAMoGlCybY4P2A5lKxoUsn_IdtDK07TFK_aklDsAVL1qH7MrIcQghcYd-7rf4i33W7TrnCJ3ZMMciZvo-BRScjyQcdwsqapMZXYU18IjmTwd-Zr4HN1W1jybwG1aDoF-PmWPvAmFnl3ea_b9w_tvN5-a_ZePn2_e7Rsr225tUFoNpLzTJHv0rYVJewmk621KyMEZP-jBKtdrh6rryXWTEQq8tgC9wvaavT7nHnL6sVFZx2UulkIwkdJWRkSFWskaV-nLf-hd2nKs11WFcpAK5FAVnpXNqZRMfjzkeTH5OCKMp77Hc99j7Xs89T0e686LS_I2LeR-b_wquIJXF2CKNcFnE-1c_ri-66RSujpxdqWO4i3lv0787-_3JmSXCg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1114947049</pqid></control><display><type>article</type><title>Lung function decline and blood lead among residents nearby to industrial complex</title><source>Springer Online Journals - JUSTICE</source><creator>Pak, Yun-Suk ; Oh, Aeri ; Kho, Young Lim ; Paek, Domyung</creator><creatorcontrib>Pak, Yun-Suk ; Oh, Aeri ; Kho, Young Lim ; Paek, Domyung</creatorcontrib><description>Purpose
This study was to ascertain the risk factors of pulmonary function decline (forced expiratory volume in 1 s [FEV
1
], forced vital capacity [FVC]) among those exposed to lead in the vicinity of industrial complex.
Methods
In total, 263 men and women, aged over 30, were recruited from two cities during a 2-year follow-up. Spirometry testing was conducted first at baseline and then after 2-years of follow-up. The change in FVC and FEV
1
during the study period was analyzed according to blood lead (BPb), urinary cotinine, and 1-hydroxypyrene, after controlling for sex, height, baseline FVC or FEV
1
, and airway hyperresponsiveness.
Results
With increase in age, both FEV
1
and FVC declined. More marked decline in FVC was noted for men than for women (
p
< 0.05), while the decline in FEV
1
was not. Biological variables, especially height (
p
< 0.05) and pulmonary status (
p
< 0.0001), were associated with the decline in both FEV
1
and FVC. Even after controlling these other variables, blood lead level was also significantly associated with the decline of FVC.
Conclusions
Even though the decline in FEV
1
and FVC with aging was within a normal range, people with smaller height were more vulnerable to the decline of both FEV
1
and FVC and especially higher level of BPb was accompanied with larger decline of FVC. Oxidative stress in relation to lead accumulation in adult may contribute to rapid aging of pulmonary function.</description><identifier>ISSN: 0340-0131</identifier><identifier>EISSN: 1432-1246</identifier><identifier>DOI: 10.1007/s00420-012-0743-y</identifier><identifier>PMID: 22294281</identifier><identifier>CODEN: IAEHDW</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Aging ; Biological and medical sciences ; Blood levels ; Chemical and industrial products toxicology. Toxic occupational diseases ; Earth and Environmental Science ; Environment ; Environment. Living conditions ; Environmental Health ; Industrial wastes ; Lead content ; Lung diseases ; Medical sciences ; Metals and various inorganic compounds ; Occupational Medicine/Industrial Medicine ; Original Article ; Oxidative stress ; Public health ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; Rehabilitation ; Respiratory function ; Risk factors ; Toxicology</subject><ispartof>International archives of occupational and environmental health, 2012-11, Vol.85 (8), p.951-959</ispartof><rights>Springer-Verlag 2012</rights><rights>2014 INIST-CNRS</rights><rights>Springer-Verlag Berlin Heidelberg 2012</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c435t-14c80e7fd8e461f3c0b8f40e82227249daf989c7d68d1756ed5ba270f8c006713</citedby><cites>FETCH-LOGICAL-c435t-14c80e7fd8e461f3c0b8f40e82227249daf989c7d68d1756ed5ba270f8c006713</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00420-012-0743-y$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00420-012-0743-y$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26554778$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22294281$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pak, Yun-Suk</creatorcontrib><creatorcontrib>Oh, Aeri</creatorcontrib><creatorcontrib>Kho, Young Lim</creatorcontrib><creatorcontrib>Paek, Domyung</creatorcontrib><title>Lung function decline and blood lead among residents nearby to industrial complex</title><title>International archives of occupational and environmental health</title><addtitle>Int Arch Occup Environ Health</addtitle><addtitle>Int Arch Occup Environ Health</addtitle><description>Purpose
This study was to ascertain the risk factors of pulmonary function decline (forced expiratory volume in 1 s [FEV
1
], forced vital capacity [FVC]) among those exposed to lead in the vicinity of industrial complex.
Methods
In total, 263 men and women, aged over 30, were recruited from two cities during a 2-year follow-up. Spirometry testing was conducted first at baseline and then after 2-years of follow-up. The change in FVC and FEV
1
during the study period was analyzed according to blood lead (BPb), urinary cotinine, and 1-hydroxypyrene, after controlling for sex, height, baseline FVC or FEV
1
, and airway hyperresponsiveness.
Results
With increase in age, both FEV
1
and FVC declined. More marked decline in FVC was noted for men than for women (
p
< 0.05), while the decline in FEV
1
was not. Biological variables, especially height (
p
< 0.05) and pulmonary status (
p
< 0.0001), were associated with the decline in both FEV
1
and FVC. Even after controlling these other variables, blood lead level was also significantly associated with the decline of FVC.
Conclusions
Even though the decline in FEV
1
and FVC with aging was within a normal range, people with smaller height were more vulnerable to the decline of both FEV
1
and FVC and especially higher level of BPb was accompanied with larger decline of FVC. Oxidative stress in relation to lead accumulation in adult may contribute to rapid aging of pulmonary function.</description><subject>Aging</subject><subject>Biological and medical sciences</subject><subject>Blood levels</subject><subject>Chemical and industrial products toxicology. Toxic occupational diseases</subject><subject>Earth and Environmental Science</subject><subject>Environment</subject><subject>Environment. Living conditions</subject><subject>Environmental Health</subject><subject>Industrial wastes</subject><subject>Lead content</subject><subject>Lung diseases</subject><subject>Medical sciences</subject><subject>Metals and various inorganic compounds</subject><subject>Occupational Medicine/Industrial Medicine</subject><subject>Original Article</subject><subject>Oxidative stress</subject><subject>Public health</subject><subject>Public health. Hygiene</subject><subject>Public health. Hygiene-occupational medicine</subject><subject>Rehabilitation</subject><subject>Respiratory function</subject><subject>Risk factors</subject><subject>Toxicology</subject><issn>0340-0131</issn><issn>1432-1246</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNp10E2LFDEQBuAgijuu_gAvEhDBS2tVOt1JH2XxCwZE0HOTTipLL-lkTLrB-febYcYPBE851FNvipex5whvEEC9LQBSQAMoGlCybY4P2A5lKxoUsn_IdtDK07TFK_aklDsAVL1qH7MrIcQghcYd-7rf4i33W7TrnCJ3ZMMciZvo-BRScjyQcdwsqapMZXYU18IjmTwd-Zr4HN1W1jybwG1aDoF-PmWPvAmFnl3ea_b9w_tvN5-a_ZePn2_e7Rsr225tUFoNpLzTJHv0rYVJewmk621KyMEZP-jBKtdrh6rryXWTEQq8tgC9wvaavT7nHnL6sVFZx2UulkIwkdJWRkSFWskaV-nLf-hd2nKs11WFcpAK5FAVnpXNqZRMfjzkeTH5OCKMp77Hc99j7Xs89T0e686LS_I2LeR-b_wquIJXF2CKNcFnE-1c_ri-66RSujpxdqWO4i3lv0787-_3JmSXCg</recordid><startdate>20121101</startdate><enddate>20121101</enddate><creator>Pak, Yun-Suk</creator><creator>Oh, Aeri</creator><creator>Kho, Young Lim</creator><creator>Paek, Domyung</creator><general>Springer-Verlag</general><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T2</scope><scope>7T5</scope><scope>7TM</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>PATMY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PYCSY</scope><scope>Q9U</scope><scope>7U1</scope><scope>7U2</scope></search><sort><creationdate>20121101</creationdate><title>Lung function decline and blood lead among residents nearby to industrial complex</title><author>Pak, Yun-Suk ; Oh, Aeri ; Kho, Young Lim ; Paek, Domyung</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c435t-14c80e7fd8e461f3c0b8f40e82227249daf989c7d68d1756ed5ba270f8c006713</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Aging</topic><topic>Biological and medical sciences</topic><topic>Blood levels</topic><topic>Chemical and industrial products toxicology. Toxic occupational diseases</topic><topic>Earth and Environmental Science</topic><topic>Environment</topic><topic>Environment. Living conditions</topic><topic>Environmental Health</topic><topic>Industrial wastes</topic><topic>Lead content</topic><topic>Lung diseases</topic><topic>Medical sciences</topic><topic>Metals and various inorganic compounds</topic><topic>Occupational Medicine/Industrial Medicine</topic><topic>Original Article</topic><topic>Oxidative stress</topic><topic>Public health</topic><topic>Public health. Hygiene</topic><topic>Public health. Hygiene-occupational medicine</topic><topic>Rehabilitation</topic><topic>Respiratory function</topic><topic>Risk factors</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pak, Yun-Suk</creatorcontrib><creatorcontrib>Oh, Aeri</creatorcontrib><creatorcontrib>Kho, Young Lim</creatorcontrib><creatorcontrib>Paek, Domyung</creatorcontrib><collection>Pascal-Francis</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Health & Medical Complete (ProQuest Database)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Agriculture & Environmental Science Database</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Science Journals (ProQuest Database)</collection><collection>Environmental Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Environmental Science Collection</collection><collection>ProQuest Central Basic</collection><collection>Risk Abstracts</collection><collection>Safety Science and Risk</collection><jtitle>International archives of occupational and environmental health</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pak, Yun-Suk</au><au>Oh, Aeri</au><au>Kho, Young Lim</au><au>Paek, Domyung</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lung function decline and blood lead among residents nearby to industrial complex</atitle><jtitle>International archives of occupational and environmental health</jtitle><stitle>Int Arch Occup Environ Health</stitle><addtitle>Int Arch Occup Environ Health</addtitle><date>2012-11-01</date><risdate>2012</risdate><volume>85</volume><issue>8</issue><spage>951</spage><epage>959</epage><pages>951-959</pages><issn>0340-0131</issn><eissn>1432-1246</eissn><coden>IAEHDW</coden><abstract>Purpose
This study was to ascertain the risk factors of pulmonary function decline (forced expiratory volume in 1 s [FEV
1
], forced vital capacity [FVC]) among those exposed to lead in the vicinity of industrial complex.
Methods
In total, 263 men and women, aged over 30, were recruited from two cities during a 2-year follow-up. Spirometry testing was conducted first at baseline and then after 2-years of follow-up. The change in FVC and FEV
1
during the study period was analyzed according to blood lead (BPb), urinary cotinine, and 1-hydroxypyrene, after controlling for sex, height, baseline FVC or FEV
1
, and airway hyperresponsiveness.
Results
With increase in age, both FEV
1
and FVC declined. More marked decline in FVC was noted for men than for women (
p
< 0.05), while the decline in FEV
1
was not. Biological variables, especially height (
p
< 0.05) and pulmonary status (
p
< 0.0001), were associated with the decline in both FEV
1
and FVC. Even after controlling these other variables, blood lead level was also significantly associated with the decline of FVC.
Conclusions
Even though the decline in FEV
1
and FVC with aging was within a normal range, people with smaller height were more vulnerable to the decline of both FEV
1
and FVC and especially higher level of BPb was accompanied with larger decline of FVC. Oxidative stress in relation to lead accumulation in adult may contribute to rapid aging of pulmonary function.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>22294281</pmid><doi>10.1007/s00420-012-0743-y</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0340-0131 |
| ispartof | International archives of occupational and environmental health, 2012-11, Vol.85 (8), p.951-959 |
| issn | 0340-0131 1432-1246 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1171874222 |
| source | Springer Online Journals - JUSTICE |
| subjects | Aging Biological and medical sciences Blood levels Chemical and industrial products toxicology. Toxic occupational diseases Earth and Environmental Science Environment Environment. Living conditions Environmental Health Industrial wastes Lead content Lung diseases Medical sciences Metals and various inorganic compounds Occupational Medicine/Industrial Medicine Original Article Oxidative stress Public health Public health. Hygiene Public health. Hygiene-occupational medicine Rehabilitation Respiratory function Risk factors Toxicology |
| title | Lung function decline and blood lead among residents nearby to industrial complex |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-07T17%3A27%3A31IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Lung%20function%20decline%20and%20blood%20lead%20among%20residents%20nearby%20to%20industrial%20complex&rft.jtitle=International%20archives%20of%20occupational%20and%20environmental%20health&rft.au=Pak,%20Yun-Suk&rft.date=2012-11-01&rft.volume=85&rft.issue=8&rft.spage=951&rft.epage=959&rft.pages=951-959&rft.issn=0340-0131&rft.eissn=1432-1246&rft.coden=IAEHDW&rft_id=info:doi/10.1007/s00420-012-0743-y&rft_dat=%3Cproquest_cross%3E1171874222%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1114947049&rft_id=info:pmid/22294281&rfr_iscdi=true |