Antihypertensive and Laxative Effects by Pharmacological Inhibition of Sodium-Proton-Exchanger Subtype 3–Mediated Sodium Absorption in the Gut

High intestinal sodium absorption is one mechanism of hypertension and constipation. The sodium-proton-exchanger subtype 3 (NHE3) is an important mediator of sodium absorption in the gut. SAR218034 (SAR) is an orally nonabsorbable specific NHE3 inhibitor. The effect of SAR (1 mg/kg per day in chow)...

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Veröffentlicht in:	Hypertension (Dallas, Tex. 1979) Tex. 1979), 2012-12, Vol.60 (6), p.1560-1567
Hauptverfasser:	Linz, Dominik, Wirth, Klaus, Linz, Wolfgang, Heuer, Hubert O O, Frick, Wendelin, Hofmeister, Armin, Heinelt, Uwe, Arndt, Petra, Schwahn, Uwe, Böhm, Michael, Ruetten, Hartmut
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antihypertensive agents Antihypertensive Agents - pharmacology Antihypertensive Agents - therapeutic use Arterial hypertension. Arterial hypotension Biological and medical sciences Blood and lymphatic vessels Blood Pressure - drug effects Blood Pressure - physiology Cardiology. Vascular system Cardiovascular system Gastrointestinal Tract - drug effects Gastrointestinal Tract - metabolism Hypertension - drug therapy Hypertension - genetics Hypertension - metabolism Medical sciences Pharmacology. Drug treatments Quinolines - pharmacology Quinolines - therapeutic use Ramipril - pharmacology Ramipril - therapeutic use Rats Rats, Inbred SHR Sodium-Hydrogen Exchanger 3 Sodium-Hydrogen Exchangers - antagonists & inhibitors Sodium-Hydrogen Exchangers - genetics Sodium-Hydrogen Exchangers - metabolism Up-Regulation
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