HPLC/UV or bioassay: two valid methods for posaconazole quantification in human serum samples

In this paper we report on the development and validation of two different methods for posaconazole quantification from serum samples, HPLC/UV and bioassay. Both methods have been validated according to international guidelines and were also applied to the analysis of 61 trough serum samples from tr...

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Veröffentlicht in:	Clinical microbiology and infection 2012-12, Vol.18 (12), p.1229-1235
Hauptverfasser:	Cendejas-Bueno, E., Forastiero, A., Rodriguez-Tudela, J.L., Cuenca-Estrella, M., Gomez-Lopez, A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics. Antiinfectious agents. Antiparasitic agents Antifungal agents Antifungal Agents - blood Bioassay Biological and medical sciences Biological Assay - methods chromatographic method Chromatography, High Pressure Liquid - methods Humans Infectious diseases Male Medical sciences Pharmacology. Drug treatments posaconazole Serum - chemistry Spectrophotometry, Ultraviolet - methods therapeutic drug monitoring Triazoles - blood
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