Lipopolysaccharide Induces the Migration of Human Dental Pulp Cells by Up-regulating miR-146a

Abstract Introduction MicroRNAs are small noncoding RNAs that play crucial roles in regulating normal and pathologic functions. Bacterial lipopolysaccharide (LPS) is one of the key regulators of pulpal pathogenesis. This study investigated how LPS regulates microRNA expression and affects the phenot...

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Veröffentlicht in:	Journal of endodontics 2012-12, Vol.38 (12), p.1598-1603
Hauptverfasser:	Wang, Min-Ching, DDS, Hung, Pei-Shih, PhD, Tu, Hsi-Feng, DDS, PhD, Shih, Wen-Yu, DDS, MS, Li, Wan-Chun, PhD, Chang, Kuo-Wei, DDS, PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Culture Techniques Cell Differentiation - physiology Cell Line Cell Movement - drug effects Cell Proliferation - drug effects Culture Media Dental Pulp - cytology Dental Pulp - drug effects Dentistry Endocrinology & Metabolism Gene Expression Regulation - drug effects Gene Knockdown Techniques Gene Silencing Humans Interleukin-1 Receptor-Associated Kinases - analysis Interleukin-1 Receptor-Associated Kinases - genetics IRAK1 Lipopolysaccharides - pharmacology LPS MicroRNAs - drug effects MicroRNAs - genetics migration miR-146a Osteogenesis - physiology Phenotype pulp Reverse Transcriptase Polymerase Chain Reaction RNA, Small Interfering - genetics TNF Receptor-Associated Factor 6 - analysis TNF Receptor-Associated Factor 6 - genetics TRAF6 Transfection Up-Regulation - drug effects
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