Perillyl alcohol for the treatment of temozolomide-resistant gliomas

Perillyl alcohol (POH) is a monoterpene that has been used orally for the treatment of systemic cancer. However, when used orally significant gastrointestinal side effects and lack of overall efficacy were documented. Recently, in a phase II trial in Brazil for the treatment of temozolomide (TMZ)-re...

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Veröffentlicht in:	Molecular cancer therapeutics 2012-11, Vol.11 (11), p.2462-2472
Hauptverfasser:	Cho, Hee-Yeon, Wang, Weijun, Jhaveri, Niyati, Torres, Shering, Tseng, Joshua, Leong, Michelle N, Lee, David Jungpa, Goldkorn, Amir, Xu, Tong, Petasis, Nicos A, Louie, Stan G, Schönthal, Axel H, Hofman, Florence M, Chen, Thomas C
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Intranasal Animals Brain Neoplasms - blood supply Brain Neoplasms - drug therapy Brain Neoplasms - pathology Cell Death - drug effects Cell Line, Tumor Cell Proliferation - drug effects Cytokines - biosynthesis Dacarbazine - analogs & derivatives Dacarbazine - chemistry Dacarbazine - pharmacology Dacarbazine - therapeutic use Drug Resistance, Neoplasm - drug effects Endoplasmic Reticulum Stress - drug effects Glioma - blood supply Glioma - drug therapy Glioma - pathology Humans Mice Monoterpenes - administration & dosage Monoterpenes - chemistry Monoterpenes - pharmacology Monoterpenes - therapeutic use Nelfinavir - pharmacology Neoplasm Invasiveness Neovascularization, Pathologic - drug therapy Neovascularization, Pathologic - pathology Pyrazoles - pharmacology Sulfonamides - pharmacology Xenograft Model Antitumor Assays
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