Bone marrow mesenchymal stem cells ameliorate hepatic ischemia/reperfusion injuries via inactivation of the MEK/ERK signaling pathway in rats

Abstract Background Primary graft dysfunction or nonfunction after liver transplantation, which is usually caused by ischemia/reperfusion injury (IRI), is a serious clinical problem. Although bone marrow mesenchymal stem cells (MSCs) have shown great potential in cell therapy for IRI in several orga...

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Veröffentlicht in:	The Journal of surgical research 2012-12, Vol.178 (2), p.935-948
Hauptverfasser:	Pan, Guo-zheng, MD, Yang, Yang, MD, Zhang, Jian, MD, Liu, Wei, PhD, Wang, Guo-ying, MD, Zhang, Ying-cai, MD, Yang, Qing, MM, Zhai, Feng-xian, MD, Tai, Yan, MM, Liu, Jian-rong, MM, Zhang, Qi, MD, PhD, Chen, Gui-hua, MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Animals Apoptosis Cell Proliferation Cell Survival - drug effects Female Humans Hydrogen Peroxide - toxicity Ischemia/reperfusion injury Liver - blood supply Liver - pathology Liver transplantation Male MAP Kinase Signaling System - physiology Mesenchymal stem cell Mesenchymal Stem Cell Transplantation Rats Rats, Sprague-Dawley Reactive oxygen species Reperfusion Injury - therapy Surgery
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