Involvement of microRNAs in epigallocatechin gallate-mediated UVB protection in human dermal fibroblasts

Involvement of microRNAs in epigallocatechin gallate-mediated UVB protection in human dermal fibroblasts

The green tea polyphenol epigallocatechin-3-gallate (EGCG) is a potent anti-oxidant and anticancer compound. Recently, EGCG-mediated UVB photoprotection was reported in normal human dermal fibroblasts (NHDFs); however, the molecular mechanism underlying this process remains unknown. Thus, we investi...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Oncology reports 2013-01, Vol.29 (1), p.253-259
Hauptverfasser: AN, IN-SOOK, AN, SUNGKWAN, PARK, SEYEON, LEE, SUNG NAE, BAE, SEUNGHEE
Format: Artikel
Sprache:eng
Schlagworte:
Antioxidants - pharmacology
Apoptosis
Biomarkers, Tumor - genetics
Catechin - analogs & derivatives
Catechin - pharmacology
Cell cycle
Cell division
Cell growth
cell viability
Cells, Cultured
Cytotoxicity
Deoxyribonucleic acid
dermal fibroblast
Dermis - drug effects
Dermis - metabolism
Dermis - radiation effects
DNA
epigallocatechin gallate
Fibroblasts
Fibroblasts - drug effects
Fibroblasts - metabolism
Fibroblasts - radiation effects
Gene expression
Gene Expression Profiling
Humans
Kinases
MicroRNAs
MicroRNAs - genetics
miRNA expression
Mitogen-Activated Protein Kinases - metabolism
Oligonucleotide Array Sequence Analysis
Ontology
Phosphorylation - drug effects
Proteins
Radiation-Protective Agents - pharmacology
Signal transduction
Skin
Studies
Ultraviolet Rays
UVB irradiation
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The green tea polyphenol epigallocatechin-3-gallate (EGCG) is a potent anti-oxidant and anticancer compound. Recently, EGCG-mediated UVB photoprotection was reported in normal human dermal fibroblasts (NHDFs); however, the molecular mechanism underlying this process remains unknown. Thus, we investigated the EGCG-specific microRNAs (miRNAs) involved in the UVB protective response in NHDFs. WST-1 assays confirmed that low doses (
ISSN:1021-335X
1791-2431
DOI:10.3892/or.2012.2083