Fish oil supplementation improved liver phospholipids fatty acid composition and parameters of oxidative stress in male wistar rats
In the present study, we examined the effects of fish oil supplementation in 3 months old male Wistar rats on changes in plasma and liver lipid metabolism and oxidative stress parameters. Twenty Wistar rats were randomly divided into two groups of ten animals: control group and intervention group, t...
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| Veröffentlicht in: | Journal of animal physiology and animal nutrition 2012-12, Vol.96 (6), p.1020-1029 |
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| container_title | Journal of animal physiology and animal nutrition |
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| creator | Popović, T Borozan, S Arsić, A Martačić, J. D Vučić, V Trbović, A Mandić, L Glibetić, M |
| description | In the present study, we examined the effects of fish oil supplementation in 3 months old male Wistar rats on changes in plasma and liver lipid metabolism and oxidative stress parameters. Twenty Wistar rats were randomly divided into two groups of ten animals: control group and intervention group, treated for 6 weeks with fish oil capsules containing 45 mg eicosapentanoic acid and 30 mg docosahexanoic acid. After intervention, biochemical parameters in plasma [triglycerides (TG), low‐density lipoprotein (LDL), high‐density lipoprotein (HDL) and total cholesterol, urea, creatinine and uric acid], fatty acid (FAs) profile of liver phospholipids and parameters of oxidative stress in liver [activity of catalase, superoxide dismutase and paraoxonase (PON1), concentration of nitrites, lipid peroxidation (LPO), free thiol (SH) groups and lactate dehydrogenase (LDH) izoenzymes were determined. Treatment with fish oil improved FAs profile of liver phospholipids, increasing n‐3 FAs and decreasing n‐6/n‐3 ratio. Significant decrease in plasma TG and LDL concentration, and increase in the level of HDL and uric acid were found in intervention group at the end of the study. Catalase activity, LPO, and nitrites concentration in liver were significantly decreased, after the supplementation, together with elevated PON1 activity. Applied treatment significantly improved plasma lipid profile, liver FAs composition and parameters of oxidative stress in male Wistar rats. |
| doi_str_mv | 10.1111/j.1439-0396.2011.01216.x |
| format | Article |
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D ; Vučić, V ; Trbović, A ; Mandić, L ; Glibetić, M</creator><creatorcontrib>Popović, T ; Borozan, S ; Arsić, A ; Martačić, J. D ; Vučić, V ; Trbović, A ; Mandić, L ; Glibetić, M</creatorcontrib><description>In the present study, we examined the effects of fish oil supplementation in 3 months old male Wistar rats on changes in plasma and liver lipid metabolism and oxidative stress parameters. Twenty Wistar rats were randomly divided into two groups of ten animals: control group and intervention group, treated for 6 weeks with fish oil capsules containing 45 mg eicosapentanoic acid and 30 mg docosahexanoic acid. After intervention, biochemical parameters in plasma [triglycerides (TG), low‐density lipoprotein (LDL), high‐density lipoprotein (HDL) and total cholesterol, urea, creatinine and uric acid], fatty acid (FAs) profile of liver phospholipids and parameters of oxidative stress in liver [activity of catalase, superoxide dismutase and paraoxonase (PON1), concentration of nitrites, lipid peroxidation (LPO), free thiol (SH) groups and lactate dehydrogenase (LDH) izoenzymes were determined. Treatment with fish oil improved FAs profile of liver phospholipids, increasing n‐3 FAs and decreasing n‐6/n‐3 ratio. Significant decrease in plasma TG and LDL concentration, and increase in the level of HDL and uric acid were found in intervention group at the end of the study. Catalase activity, LPO, and nitrites concentration in liver were significantly decreased, after the supplementation, together with elevated PON1 activity. Applied treatment significantly improved plasma lipid profile, liver FAs composition and parameters of oxidative stress in male Wistar rats.</description><identifier>ISSN: 0931-2439</identifier><identifier>EISSN: 1439-0396</identifier><identifier>DOI: 10.1111/j.1439-0396.2011.01216.x</identifier><identifier>PMID: 21883500</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>aerobiosis ; Animal Feed ; Animal Nutritional Physiological Phenomena ; Animals ; blood lipids ; catalase ; Cholesterol ; Diet ; Dietary Supplements ; docosahexaenoic acid ; eicosapentaenoic acid ; fatty acid composition ; Fatty acids ; Fatty Acids - chemistry ; Fatty Acids - metabolism ; fish oil ; Fish oils ; Fish Oils - administration & dosage ; Fish Oils - pharmacology ; high density lipoprotein ; lactate dehydrogenase ; lipid metabolism ; lipid peroxidation ; Lipids ; Lipids - blood ; liver ; Liver - chemistry ; Liver - metabolism ; low density lipoprotein ; Male ; nitrites ; oxidative stress ; Oxidative Stress - drug effects ; phospholipids ; Phospholipids - chemistry ; Phospholipids - metabolism ; Rats ; Rats, Wistar ; Rodents ; superoxide dismutase ; thiols ; triacylglycerols ; urea ; uric acid ; wistar rats</subject><ispartof>Journal of animal physiology and animal nutrition, 2012-12, Vol.96 (6), p.1020-1029</ispartof><rights>2011 Blackwell Verlag GmbH</rights><rights>2011 Blackwell Verlag GmbH.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4926-a01d1de12d92c5b77d090eb8ff54356636613ed787e1eae285da219676413a343</citedby><cites>FETCH-LOGICAL-c4926-a01d1de12d92c5b77d090eb8ff54356636613ed787e1eae285da219676413a343</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1439-0396.2011.01216.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1439-0396.2011.01216.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21883500$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Popović, T</creatorcontrib><creatorcontrib>Borozan, S</creatorcontrib><creatorcontrib>Arsić, A</creatorcontrib><creatorcontrib>Martačić, J. D</creatorcontrib><creatorcontrib>Vučić, V</creatorcontrib><creatorcontrib>Trbović, A</creatorcontrib><creatorcontrib>Mandić, L</creatorcontrib><creatorcontrib>Glibetić, M</creatorcontrib><title>Fish oil supplementation improved liver phospholipids fatty acid composition and parameters of oxidative stress in male wistar rats</title><title>Journal of animal physiology and animal nutrition</title><addtitle>J Anim Physiol Anim Nutr (Berl)</addtitle><description>In the present study, we examined the effects of fish oil supplementation in 3 months old male Wistar rats on changes in plasma and liver lipid metabolism and oxidative stress parameters. Twenty Wistar rats were randomly divided into two groups of ten animals: control group and intervention group, treated for 6 weeks with fish oil capsules containing 45 mg eicosapentanoic acid and 30 mg docosahexanoic acid. After intervention, biochemical parameters in plasma [triglycerides (TG), low‐density lipoprotein (LDL), high‐density lipoprotein (HDL) and total cholesterol, urea, creatinine and uric acid], fatty acid (FAs) profile of liver phospholipids and parameters of oxidative stress in liver [activity of catalase, superoxide dismutase and paraoxonase (PON1), concentration of nitrites, lipid peroxidation (LPO), free thiol (SH) groups and lactate dehydrogenase (LDH) izoenzymes were determined. Treatment with fish oil improved FAs profile of liver phospholipids, increasing n‐3 FAs and decreasing n‐6/n‐3 ratio. Significant decrease in plasma TG and LDL concentration, and increase in the level of HDL and uric acid were found in intervention group at the end of the study. Catalase activity, LPO, and nitrites concentration in liver were significantly decreased, after the supplementation, together with elevated PON1 activity. Applied treatment significantly improved plasma lipid profile, liver FAs composition and parameters of oxidative stress in male Wistar rats.</description><subject>aerobiosis</subject><subject>Animal Feed</subject><subject>Animal Nutritional Physiological Phenomena</subject><subject>Animals</subject><subject>blood lipids</subject><subject>catalase</subject><subject>Cholesterol</subject><subject>Diet</subject><subject>Dietary Supplements</subject><subject>docosahexaenoic acid</subject><subject>eicosapentaenoic acid</subject><subject>fatty acid composition</subject><subject>Fatty acids</subject><subject>Fatty Acids - chemistry</subject><subject>Fatty Acids - metabolism</subject><subject>fish oil</subject><subject>Fish oils</subject><subject>Fish Oils - administration & dosage</subject><subject>Fish Oils - pharmacology</subject><subject>high density lipoprotein</subject><subject>lactate dehydrogenase</subject><subject>lipid metabolism</subject><subject>lipid peroxidation</subject><subject>Lipids</subject><subject>Lipids - blood</subject><subject>liver</subject><subject>Liver - chemistry</subject><subject>Liver - metabolism</subject><subject>low density lipoprotein</subject><subject>Male</subject><subject>nitrites</subject><subject>oxidative stress</subject><subject>Oxidative Stress - drug effects</subject><subject>phospholipids</subject><subject>Phospholipids - chemistry</subject><subject>Phospholipids - metabolism</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Rodents</subject><subject>superoxide dismutase</subject><subject>thiols</subject><subject>triacylglycerols</subject><subject>urea</subject><subject>uric acid</subject><subject>wistar rats</subject><issn>0931-2439</issn><issn>1439-0396</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc1u1DAUhSMEokPhFcASGzYZfGPHiRcsUEWnRVUBlVKJjeWJb6iHJA52Mp1Z8-I4TZkFK65k-cr-zvHPSRICdAmx3m6WwJlMKZNimVGAJYUMxHL3KFkcNh4nCyoZpFlcOEqehbChFIqciqfJUQZlyXJKF8nvUxtuibMNCWPfN9hiN-jBuo7Ytvdui4Y0doue9LcuxNHY3ppAaj0Me6Ira0jl2t4Fe6_RnSG99rrFAX0griZuZ0302yIJg8cQiO1IqxskdzYM2hOvh_A8eVLrJuCLh_k4uT798PXkLL34tDo_eX-RVlxmItUUDBiEzMisytdFYaikuC7rOucsF4IJAQxNURYIqDErc6MzkKIQHJhmnB0nb2bf-LBfI4ZBtTZU2DS6QzcGBZADZQUVWURf_4Nu3Oi7eLtIcSak5JJGqpypyrsQPNaq97bVfq-AqikotVFTHmrKQ01Bqfug1C5KXz4cMK5bNAfh32Qi8G4G7myD-_82Vh8_X05d1KezPv4z7g567X8qUbAiVzeXK5XzqxW_-fJNfY_8q5mvtVP6h7dBXV9FZ05jSV4C-wOnLrtR</recordid><startdate>201212</startdate><enddate>201212</enddate><creator>Popović, T</creator><creator>Borozan, S</creator><creator>Arsić, A</creator><creator>Martačić, J. D</creator><creator>Vučić, V</creator><creator>Trbović, A</creator><creator>Mandić, L</creator><creator>Glibetić, M</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>FBQ</scope><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>201212</creationdate><title>Fish oil supplementation improved liver phospholipids fatty acid composition and parameters of oxidative stress in male wistar rats</title><author>Popović, T ; Borozan, S ; Arsić, A ; Martačić, J. D ; Vučić, V ; Trbović, A ; Mandić, L ; Glibetić, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4926-a01d1de12d92c5b77d090eb8ff54356636613ed787e1eae285da219676413a343</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>aerobiosis</topic><topic>Animal Feed</topic><topic>Animal Nutritional Physiological Phenomena</topic><topic>Animals</topic><topic>blood lipids</topic><topic>catalase</topic><topic>Cholesterol</topic><topic>Diet</topic><topic>Dietary Supplements</topic><topic>docosahexaenoic acid</topic><topic>eicosapentaenoic acid</topic><topic>fatty acid composition</topic><topic>Fatty acids</topic><topic>Fatty Acids - chemistry</topic><topic>Fatty Acids - metabolism</topic><topic>fish oil</topic><topic>Fish oils</topic><topic>Fish Oils - administration & dosage</topic><topic>Fish Oils - pharmacology</topic><topic>high density lipoprotein</topic><topic>lactate dehydrogenase</topic><topic>lipid metabolism</topic><topic>lipid peroxidation</topic><topic>Lipids</topic><topic>Lipids - blood</topic><topic>liver</topic><topic>Liver - chemistry</topic><topic>Liver - metabolism</topic><topic>low density lipoprotein</topic><topic>Male</topic><topic>nitrites</topic><topic>oxidative stress</topic><topic>Oxidative Stress - drug effects</topic><topic>phospholipids</topic><topic>Phospholipids - chemistry</topic><topic>Phospholipids - metabolism</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Rodents</topic><topic>superoxide dismutase</topic><topic>thiols</topic><topic>triacylglycerols</topic><topic>urea</topic><topic>uric acid</topic><topic>wistar rats</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Popović, T</creatorcontrib><creatorcontrib>Borozan, S</creatorcontrib><creatorcontrib>Arsić, A</creatorcontrib><creatorcontrib>Martačić, J. 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D</au><au>Vučić, V</au><au>Trbović, A</au><au>Mandić, L</au><au>Glibetić, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fish oil supplementation improved liver phospholipids fatty acid composition and parameters of oxidative stress in male wistar rats</atitle><jtitle>Journal of animal physiology and animal nutrition</jtitle><addtitle>J Anim Physiol Anim Nutr (Berl)</addtitle><date>2012-12</date><risdate>2012</risdate><volume>96</volume><issue>6</issue><spage>1020</spage><epage>1029</epage><pages>1020-1029</pages><issn>0931-2439</issn><eissn>1439-0396</eissn><abstract>In the present study, we examined the effects of fish oil supplementation in 3 months old male Wistar rats on changes in plasma and liver lipid metabolism and oxidative stress parameters. Twenty Wistar rats were randomly divided into two groups of ten animals: control group and intervention group, treated for 6 weeks with fish oil capsules containing 45 mg eicosapentanoic acid and 30 mg docosahexanoic acid. After intervention, biochemical parameters in plasma [triglycerides (TG), low‐density lipoprotein (LDL), high‐density lipoprotein (HDL) and total cholesterol, urea, creatinine and uric acid], fatty acid (FAs) profile of liver phospholipids and parameters of oxidative stress in liver [activity of catalase, superoxide dismutase and paraoxonase (PON1), concentration of nitrites, lipid peroxidation (LPO), free thiol (SH) groups and lactate dehydrogenase (LDH) izoenzymes were determined. Treatment with fish oil improved FAs profile of liver phospholipids, increasing n‐3 FAs and decreasing n‐6/n‐3 ratio. Significant decrease in plasma TG and LDL concentration, and increase in the level of HDL and uric acid were found in intervention group at the end of the study. Catalase activity, LPO, and nitrites concentration in liver were significantly decreased, after the supplementation, together with elevated PON1 activity. Applied treatment significantly improved plasma lipid profile, liver FAs composition and parameters of oxidative stress in male Wistar rats.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>21883500</pmid><doi>10.1111/j.1439-0396.2011.01216.x</doi><tpages>10</tpages></addata></record> |
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| subjects | aerobiosis Animal Feed Animal Nutritional Physiological Phenomena Animals blood lipids catalase Cholesterol Diet Dietary Supplements docosahexaenoic acid eicosapentaenoic acid fatty acid composition Fatty acids Fatty Acids - chemistry Fatty Acids - metabolism fish oil Fish oils Fish Oils - administration & dosage Fish Oils - pharmacology high density lipoprotein lactate dehydrogenase lipid metabolism lipid peroxidation Lipids Lipids - blood liver Liver - chemistry Liver - metabolism low density lipoprotein Male nitrites oxidative stress Oxidative Stress - drug effects phospholipids Phospholipids - chemistry Phospholipids - metabolism Rats Rats, Wistar Rodents superoxide dismutase thiols triacylglycerols urea uric acid wistar rats |
| title | Fish oil supplementation improved liver phospholipids fatty acid composition and parameters of oxidative stress in male wistar rats |
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