Netrin-4 overexpression suppresses primary and metastatic colorectal tumor progression

Tumor angiogenesis is closely associated with clinical staging and has been proposed to correlate with clinical response in terms of subsequent metastases following primary resection. Netrin-4 (NT-4) regulates angiogenic responses. Therefore, we sought to examine the effects of NT-4 on the primary t...

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Veröffentlicht in:	Oncology reports 2013-01, Vol.29 (1), p.73-78
Hauptverfasser:	EVENO, CLARISSE, CONTRERES, JEAN-OLIVIER, HAINAUD, PATRICIA, NEMETH, JUDITH, DUPUY, EVELYNE, POCARD, MARC
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Animals Apoptosis Cancer therapies Cell growth colon cancer Colonic Neoplasms - metabolism Colonic Neoplasms - pathology Colonic Neoplasms - prevention & control Colorectal cancer Disease Progression Female Humans Laboratory animals liver metastasis Liver Neoplasms - metabolism Liver Neoplasms - prevention & control Liver Neoplasms - secondary Lung Neoplasms - metabolism Lung Neoplasms - prevention & control Lung Neoplasms - secondary Lymphatic Metastasis Metastasis Mice Mice, Nude Neoplasm Recurrence, Local - metabolism Neoplasm Recurrence, Local - prevention & control Neoplasm Recurrence, Local - secondary Nerve Growth Factors - genetics Nerve Growth Factors - metabolism Netrin-4 Netrins Rodents Tumor Cells, Cultured Tumors Vascular endothelial growth factor
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