Longevity-promoting effects of 4-hydroxy-E-globularinin in Caenorhabditis elegans

In modern times, there has been a major increase in the use of plants or herbal constituents for the prevention of age-related disorders. 4-Hydroxy-E-globularinin (4-HEG) is an iridoid and a major component of Premna integrifolia. This investigation represents a breakthrough in geriatrics by showing...

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Veröffentlicht in:	Free radical biology & medicine 2012-11, Vol.53 (10), p.1848-1856
Hauptverfasser:	Shukla, Virendra, Yadav, Deepti, Phulara, Suresh C., Gupta, M.M., Saikia, Shilpi K., Pandey, Rakesh
Format:	Artikel
Sprache:	eng
Schlagworte:	4-Hydroxy-E-globularinin Aging Aging - drug effects animal models Animals Caenorhabditis elegans Caenorhabditis elegans - drug effects Caenorhabditis elegans - genetics Caenorhabditis elegans - metabolism Caenorhabditis elegans - physiology Caenorhabditis elegans Proteins - biosynthesis Caenorhabditis elegans Proteins - genetics Caenorhabditis elegans Proteins - metabolism Chemotaxis - drug effects Forkhead Transcription Factors Free radicals Free Radicals - metabolism functional foods Gene Expression Regulation - drug effects genes Genes, Helminth Heat-Shock Proteins - biosynthesis Heat-Shock Proteins - genetics Iridoid Iridoids - chemistry Iridoids - pharmacology Life Expectancy Life span longevity Longevity - drug effects Models, Animal mutants oxidative stress Oxidative Stress - drug effects Plant Bark - metabolism Premna quantitative polymerase chain reaction Reactive oxygen species Reactive Oxygen Species - metabolism Signal Transduction superoxide dismutase transcription (genetics) Transcription Factors - metabolism Transcriptional Activation
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