Casticin induces growth suppression and cell cycle arrest through activation of FOXO3a in hepatocellular carcinoma

Casticin, a polymethoxyflavone, has been reported to exert anticancer activities. The objectives of this study were to examine the molecular mechanisms by which casticin induces the growth inhibition and cell cycle arrest in human hepatocellular carcinoma (HCC) cells. The HCC cell lines Hep G2 and P...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Oncology reports 2013-01, Vol.29 (1), p.103-108
Hauptverfasser:	HE, LIHUA, YANG, XIAOHONG, CAO, XIAOCHENG, LIU, FEI, QUAN, MEIFANG, CAO, JIANGUO
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Blotting, Western Cancer therapies Carcinoma, Hepatocellular - drug therapy Carcinoma, Hepatocellular - metabolism Carcinoma, Hepatocellular - pathology casticin Cell cycle Cell Cycle Checkpoints - drug effects Cell Proliferation - drug effects Cell Survival - drug effects Cyclin B - metabolism Cyclin-Dependent Kinase Inhibitor p27 - metabolism Cyclin-dependent kinases Flavonoids - pharmacology Forkhead Box Protein M1 Forkhead Box Protein O3 Forkhead Transcription Factors - antagonists & inhibitors Forkhead Transcription Factors - genetics Forkhead Transcription Factors - metabolism FOXM1 FOXO3a Gene Expression Regulation, Neoplastic hepatocellular carcinoma Humans Investigations Kinases Liver cancer Liver Neoplasms - drug therapy Liver Neoplasms - metabolism Liver Neoplasms - pathology Medical prognosis Phosphorylation Proto-Oncogene Proteins c-akt - metabolism RNA, Small Interfering - genetics Transcription factors Tumor Cells, Cultured
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!