The correlation between early lymphocyte count post-allogeneic hematopoietic stem cell transplantation and prognosis in leukemia patients
To analyze the correlation between early lymphocyte count (lymphocyte count on day 30, LC30) post-allogeneic hematopoietic stem cell transplantation (allo-HSCT) and transplant prognosis in leukemia patients. The data from 124 consecutive patients undergoing allo-HSCT for leukemia from January 2003 t...
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| Veröffentlicht in: | Zhōnghuá xuèyèxué zázhì 2012-08, Vol.33 (8), p.632-636 |
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| container_title | Zhōnghuá xuèyèxué zázhì |
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| creator | Wang, Jia-qi Tan, Jie-wen Xu, Jin-huan Xiao, Yi Meng, Fan-kai Zhang, Dong-hua Zhang, Yi-cheng |
| description | To analyze the correlation between early lymphocyte count (lymphocyte count on day 30, LC30) post-allogeneic hematopoietic stem cell transplantation (allo-HSCT) and transplant prognosis in leukemia patients.
The data from 124 consecutive patients undergoing allo-HSCT for leukemia from January 2003 to April 2011 was analyzed retrospectively. LC30 post-allo-HSCT correlated with 5-year overall survival (OS), 5-year relapse rate (RR), 5-year nonrelapse mortality (NRM), accumulative rate of acute graft versus host disease (aGVHD) and chronic graft versus host disease (cGVHD) was studied.
Univariate analysis indicated that patients with LC30 ≥ 0.40×10(9)/L had higher 5-year OS than those with LC30 < 0.40×10(9)/L \[(62.2 ± 5.8)% vs (37.0 ± 8.6)%, P = 0.003\], lower 5-year RR\[(13.9 ± 4.7)% vs (32.0 ± 8.4)%, P = 0.027\], lower 5-year NRM \[(31.3 ± 5.8)% vs (45.0 ± 9.3)%, P = 0.048)\], and higher cGVHD cumulative incidence \[(82.9 ± 4.6)% vs (62.7 ± 11.1)%, P = 0.042)\]. Multivariate analysis also suggested that LC30 |
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The data from 124 consecutive patients undergoing allo-HSCT for leukemia from January 2003 to April 2011 was analyzed retrospectively. LC30 post-allo-HSCT correlated with 5-year overall survival (OS), 5-year relapse rate (RR), 5-year nonrelapse mortality (NRM), accumulative rate of acute graft versus host disease (aGVHD) and chronic graft versus host disease (cGVHD) was studied.
Univariate analysis indicated that patients with LC30 ≥ 0.40×10(9)/L had higher 5-year OS than those with LC30 < 0.40×10(9)/L \[(62.2 ± 5.8)% vs (37.0 ± 8.6)%, P = 0.003\], lower 5-year RR\[(13.9 ± 4.7)% vs (32.0 ± 8.4)%, P = 0.027\], lower 5-year NRM \[(31.3 ± 5.8)% vs (45.0 ± 9.3)%, P = 0.048)\], and higher cGVHD cumulative incidence \[(82.9 ± 4.6)% vs (62.7 ± 11.1)%, P = 0.042)\]. Multivariate analysis also suggested that LC30</description><identifier>ISSN: 0253-2727</identifier><identifier>PMID: 23134857</identifier><language>chi</language><publisher>China</publisher><subject>Adolescent ; Adult ; Child ; Child, Preschool ; Female ; Hematopoietic Stem Cell Transplantation ; Humans ; Leukemia - diagnosis ; Leukemia - surgery ; Lymphocyte Count ; Male ; Middle Aged ; Prognosis ; Retrospective Studies ; Young Adult</subject><ispartof>Zhōnghuá xuèyèxué zázhì, 2012-08, Vol.33 (8), p.632-636</ispartof><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23134857$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Jia-qi</creatorcontrib><creatorcontrib>Tan, Jie-wen</creatorcontrib><creatorcontrib>Xu, Jin-huan</creatorcontrib><creatorcontrib>Xiao, Yi</creatorcontrib><creatorcontrib>Meng, Fan-kai</creatorcontrib><creatorcontrib>Zhang, Dong-hua</creatorcontrib><creatorcontrib>Zhang, Yi-cheng</creatorcontrib><title>The correlation between early lymphocyte count post-allogeneic hematopoietic stem cell transplantation and prognosis in leukemia patients</title><title>Zhōnghuá xuèyèxué zázhì</title><addtitle>Zhonghua Xue Ye Xue Za Zhi</addtitle><description>To analyze the correlation between early lymphocyte count (lymphocyte count on day 30, LC30) post-allogeneic hematopoietic stem cell transplantation (allo-HSCT) and transplant prognosis in leukemia patients.
The data from 124 consecutive patients undergoing allo-HSCT for leukemia from January 2003 to April 2011 was analyzed retrospectively. LC30 post-allo-HSCT correlated with 5-year overall survival (OS), 5-year relapse rate (RR), 5-year nonrelapse mortality (NRM), accumulative rate of acute graft versus host disease (aGVHD) and chronic graft versus host disease (cGVHD) was studied.
Univariate analysis indicated that patients with LC30 ≥ 0.40×10(9)/L had higher 5-year OS than those with LC30 < 0.40×10(9)/L \[(62.2 ± 5.8)% vs (37.0 ± 8.6)%, P = 0.003\], lower 5-year RR\[(13.9 ± 4.7)% vs (32.0 ± 8.4)%, P = 0.027\], lower 5-year NRM \[(31.3 ± 5.8)% vs (45.0 ± 9.3)%, P = 0.048)\], and higher cGVHD cumulative incidence \[(82.9 ± 4.6)% vs (62.7 ± 11.1)%, P = 0.042)\]. Multivariate analysis also suggested that LC30</description><subject>Adolescent</subject><subject>Adult</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Female</subject><subject>Hematopoietic Stem Cell Transplantation</subject><subject>Humans</subject><subject>Leukemia - diagnosis</subject><subject>Leukemia - surgery</subject><subject>Lymphocyte Count</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>Young Adult</subject><issn>0253-2727</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo10MtqwzAQBVAvWpqQ5heKlt0YJI_8WpbQFwS6SddmLI8TUVlSLZniT-hf1yHparhwuFzmJlnzLIc0K7NylWxD0C3PBRQVAL9LVhkIkFVerpPfw4mYcuNIBqN2lrUUf4gsIxzNzMw8-JNTczyjyUbmXYgpGuOOZEkrdqIBo_NOU1xSiDQwRcawOKIN3qCNl1q0HfOjO1oXdGDaMkPTFw0amV8A2Rjuk9seTaDt9W6Sz5fnw-4t3X-8vu-e9qkXWRHTktdSFVADCmwrrkB0HLpWYlGojhA41XWGEkjwvlW8q0TPFyB5X4oKSgmb5PHSu8z5nijEZtDhvBktuSk0QuSCA9SyXujDlU7tQF3jRz3gODf_74M_5DxvjA</recordid><startdate>201208</startdate><enddate>201208</enddate><creator>Wang, Jia-qi</creator><creator>Tan, Jie-wen</creator><creator>Xu, Jin-huan</creator><creator>Xiao, Yi</creator><creator>Meng, Fan-kai</creator><creator>Zhang, Dong-hua</creator><creator>Zhang, Yi-cheng</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>201208</creationdate><title>The correlation between early lymphocyte count post-allogeneic hematopoietic stem cell transplantation and prognosis in leukemia patients</title><author>Wang, Jia-qi ; Tan, Jie-wen ; Xu, Jin-huan ; Xiao, Yi ; Meng, Fan-kai ; Zhang, Dong-hua ; Zhang, Yi-cheng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p126t-7094c6393a1ab80c31d03db4a66cdea30e992a43e10fbc0d81f003d40f7183743</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>chi</language><creationdate>2012</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Female</topic><topic>Hematopoietic Stem Cell Transplantation</topic><topic>Humans</topic><topic>Leukemia - diagnosis</topic><topic>Leukemia - surgery</topic><topic>Lymphocyte Count</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><topic>Young Adult</topic><toplevel>online_resources</toplevel><creatorcontrib>Wang, Jia-qi</creatorcontrib><creatorcontrib>Tan, Jie-wen</creatorcontrib><creatorcontrib>Xu, Jin-huan</creatorcontrib><creatorcontrib>Xiao, Yi</creatorcontrib><creatorcontrib>Meng, Fan-kai</creatorcontrib><creatorcontrib>Zhang, Dong-hua</creatorcontrib><creatorcontrib>Zhang, Yi-cheng</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Zhōnghuá xuèyèxué zázhì</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Jia-qi</au><au>Tan, Jie-wen</au><au>Xu, Jin-huan</au><au>Xiao, Yi</au><au>Meng, Fan-kai</au><au>Zhang, Dong-hua</au><au>Zhang, Yi-cheng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The correlation between early lymphocyte count post-allogeneic hematopoietic stem cell transplantation and prognosis in leukemia patients</atitle><jtitle>Zhōnghuá xuèyèxué zázhì</jtitle><addtitle>Zhonghua Xue Ye Xue Za Zhi</addtitle><date>2012-08</date><risdate>2012</risdate><volume>33</volume><issue>8</issue><spage>632</spage><epage>636</epage><pages>632-636</pages><issn>0253-2727</issn><abstract>To analyze the correlation between early lymphocyte count (lymphocyte count on day 30, LC30) post-allogeneic hematopoietic stem cell transplantation (allo-HSCT) and transplant prognosis in leukemia patients.
The data from 124 consecutive patients undergoing allo-HSCT for leukemia from January 2003 to April 2011 was analyzed retrospectively. LC30 post-allo-HSCT correlated with 5-year overall survival (OS), 5-year relapse rate (RR), 5-year nonrelapse mortality (NRM), accumulative rate of acute graft versus host disease (aGVHD) and chronic graft versus host disease (cGVHD) was studied.
Univariate analysis indicated that patients with LC30 ≥ 0.40×10(9)/L had higher 5-year OS than those with LC30 < 0.40×10(9)/L \[(62.2 ± 5.8)% vs (37.0 ± 8.6)%, P = 0.003\], lower 5-year RR\[(13.9 ± 4.7)% vs (32.0 ± 8.4)%, P = 0.027\], lower 5-year NRM \[(31.3 ± 5.8)% vs (45.0 ± 9.3)%, P = 0.048)\], and higher cGVHD cumulative incidence \[(82.9 ± 4.6)% vs (62.7 ± 11.1)%, P = 0.042)\]. Multivariate analysis also suggested that LC30</abstract><cop>China</cop><pmid>23134857</pmid><tpages>5</tpages></addata></record> |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Adolescent Adult Child Child, Preschool Female Hematopoietic Stem Cell Transplantation Humans Leukemia - diagnosis Leukemia - surgery Lymphocyte Count Male Middle Aged Prognosis Retrospective Studies Young Adult |
| title | The correlation between early lymphocyte count post-allogeneic hematopoietic stem cell transplantation and prognosis in leukemia patients |
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