Somatostatin antagonist potentiates haloperidol-induced catalepsy in the aged rat

Extrapyramidal motor signs are the major features of Parkinson's disease (PD). It is unclear whether there is a link between these signs and such PD-associated factors as aging and somatostatin deficiency. In this study, the intensity of haloperidol-induced catalepsy was examined in young and a...

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Veröffentlicht in:	Pharmacology, biochemistry and behavior biochemistry and behavior, 2012-12, Vol.103 (2), p.295-298
Hauptverfasser:	Ionov, Ilya D., Severtsev, Nicholas N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Animals Antipsychotic Agents - adverse effects Catalepsy Catalepsy - chemically induced Drug Synergism Extrapyramidal signs Haloperidol - adverse effects Male Parkinson's disease Rats Rats, Wistar Somatostatin Somatostatin - antagonists & inhibitors
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