Distinct Pattern of Immunophenotypic Features of Innate and Adaptive Immunity as a Putative Signature of Clinical and Laboratorial Status of Patients with Localized Cutaneous Leishmaniasis
In this study, we have analysed the phenotypic features of innate/adaptive immunity of patients with localized cutaneous leishmaniasis (LCL), categorized according to their clinical/laboratorial status, including number of lesion (L1; L2–4), days of illness duration (≤60;>60) and positivity in th...
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| Veröffentlicht in: | Scandinavian journal of immunology 2012-10, Vol.76 (4), p.421-432 |
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| creator | Freitas-Teixeira, P. M. Silveira-Lemos, D. Giunchetti, R. C. Baratta-Masini, A. Mayrink, W. Peruhype-Magalhães, V. Rocha, R. D. R. Campi-Azevedo, A. C. Teixeira-Carvalho, A. Martins-Filho, O. A. |
| description | In this study, we have analysed the phenotypic features of innate/adaptive immunity of patients with localized cutaneous leishmaniasis (LCL), categorized according to their clinical/laboratorial status, including number of lesion (L1; L2–4), days of illness duration (≤60;>60) and positivity in the Montenegro skin test (MT−;MT+). Our findings highlighted a range of phenotypic features observed in patients with LCL (↑%HLA‐DR+ neutrophils; ↑CD8+ HLA‐DR+/CD4+ HLA‐DR+ T cell ratio; ↑HLA‐DR in B lymphocytes, ↑%CD23+ neutrophils, monocytes and B cells; ↑α‐Leishmania IgG and ↑serum + ). Selective changes were observed in L1 (↑%HLA‐DR+ neutrophils, ↑CD8+ HLA‐DR+/CD4+ HLA‐DR+ T cell ratio and ↑serum + ) as compared to L2–4 (↑%CD5− B cells; ↑CD23+ B cells and ↑α‐Leishmania IgG). Whilst ≤60 presented a mixed profile of innate/adaptive immunity (↓%CD28+ neutrophils and ↑%CD4+ T cells), >60 showed a well‐known leishmanicidal events (↑CD8+ T cells; ↑serum + and ↑α‐Leishmania IgG). MT+ patients showed increased putative leishmanicidal capacity (↑%HLA‐DR+ neutrophils; ↑%CD23+ monocytes; ↑CD8+ HLA‐DR+/CD4+ HLA‐DR+ T cell ratio and ↑ serum + ). Overall, a range of immunological biomarkers illustrates the complex immunological network associated with distinct clinical/laboratorial features of LCL with applicability in clinical studies. |
| doi_str_mv | 10.1111/j.1365-3083.2012.02748.x |
| format | Article |
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M. ; Silveira-Lemos, D. ; Giunchetti, R. C. ; Baratta-Masini, A. ; Mayrink, W. ; Peruhype-Magalhães, V. ; Rocha, R. D. R. ; Campi-Azevedo, A. C. ; Teixeira-Carvalho, A. ; Martins-Filho, O. A.</creator><creatorcontrib>Freitas-Teixeira, P. M. ; Silveira-Lemos, D. ; Giunchetti, R. C. ; Baratta-Masini, A. ; Mayrink, W. ; Peruhype-Magalhães, V. ; Rocha, R. D. R. ; Campi-Azevedo, A. C. ; Teixeira-Carvalho, A. ; Martins-Filho, O. A.</creatorcontrib><description>In this study, we have analysed the phenotypic features of innate/adaptive immunity of patients with localized cutaneous leishmaniasis (LCL), categorized according to their clinical/laboratorial status, including number of lesion (L1; L2–4), days of illness duration (≤60;>60) and positivity in the Montenegro skin test (MT−;MT+). Our findings highlighted a range of phenotypic features observed in patients with LCL (↑%HLA‐DR+ neutrophils; ↑CD8+ HLA‐DR+/CD4+ HLA‐DR+ T cell ratio; ↑HLA‐DR in B lymphocytes, ↑%CD23+ neutrophils, monocytes and B cells; ↑α‐Leishmania IgG and ↑serum + ). Selective changes were observed in L1 (↑%HLA‐DR+ neutrophils, ↑CD8+ HLA‐DR+/CD4+ HLA‐DR+ T cell ratio and ↑serum + ) as compared to L2–4 (↑%CD5− B cells; ↑CD23+ B cells and ↑α‐Leishmania IgG). Whilst ≤60 presented a mixed profile of innate/adaptive immunity (↓%CD28+ neutrophils and ↑%CD4+ T cells), >60 showed a well‐known leishmanicidal events (↑CD8+ T cells; ↑serum + and ↑α‐Leishmania IgG). MT+ patients showed increased putative leishmanicidal capacity (↑%HLA‐DR+ neutrophils; ↑%CD23+ monocytes; ↑CD8+ HLA‐DR+/CD4+ HLA‐DR+ T cell ratio and ↑ serum + ). Overall, a range of immunological biomarkers illustrates the complex immunological network associated with distinct clinical/laboratorial features of LCL with applicability in clinical studies.</description><identifier>ISSN: 0300-9475</identifier><identifier>EISSN: 1365-3083</identifier><identifier>DOI: 10.1111/j.1365-3083.2012.02748.x</identifier><identifier>PMID: 22823491</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adaptive Immunity ; Adolescent ; Adult ; Aged ; Aged, 80 and over ; Antigens, CD - blood ; Antigens, CD - immunology ; B-Lymphocytes - immunology ; B-Lymphocytes - parasitology ; B-Lymphocytes - pathology ; Biomarkers - blood ; Child ; Child, Preschool ; Female ; HLA-DR Antigens - blood ; HLA-DR Antigens - immunology ; Humans ; Immunity, Innate ; Immunophenotyping ; Infant ; Leishmania braziliensis - immunology ; Leishmaniasis, Cutaneous - immunology ; Leishmaniasis, Cutaneous - parasitology ; Leishmaniasis, Cutaneous - pathology ; Male ; Middle Aged ; Neutrophils - immunology ; Neutrophils - parasitology ; Neutrophils - pathology ; Nitrates - blood ; Nitrates - immunology ; Nitrites - blood ; Nitrites - immunology ; Skin - immunology ; Skin - parasitology ; Skin - pathology ; T-Lymphocytes - immunology ; T-Lymphocytes - parasitology ; T-Lymphocytes - pathology</subject><ispartof>Scandinavian journal of immunology, 2012-10, Vol.76 (4), p.421-432</ispartof><rights>2012 The Authors. Scandinavian Journal of Immunology © 2012 Blackwell Publishing Ltd</rights><rights>2012 The Authors. Scandinavian Journal of Immunology © 2012 Blackwell Publishing Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5188-477c324692aa19ace04b78061950ea78e914b57331f11d774c44c23fd09f884d3</citedby><cites>FETCH-LOGICAL-c5188-477c324692aa19ace04b78061950ea78e914b57331f11d774c44c23fd09f884d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-3083.2012.02748.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-3083.2012.02748.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,1427,27901,27902,45550,45551,46384,46808</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22823491$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Freitas-Teixeira, P. M.</creatorcontrib><creatorcontrib>Silveira-Lemos, D.</creatorcontrib><creatorcontrib>Giunchetti, R. C.</creatorcontrib><creatorcontrib>Baratta-Masini, A.</creatorcontrib><creatorcontrib>Mayrink, W.</creatorcontrib><creatorcontrib>Peruhype-Magalhães, V.</creatorcontrib><creatorcontrib>Rocha, R. D. R.</creatorcontrib><creatorcontrib>Campi-Azevedo, A. C.</creatorcontrib><creatorcontrib>Teixeira-Carvalho, A.</creatorcontrib><creatorcontrib>Martins-Filho, O. A.</creatorcontrib><title>Distinct Pattern of Immunophenotypic Features of Innate and Adaptive Immunity as a Putative Signature of Clinical and Laboratorial Status of Patients with Localized Cutaneous Leishmaniasis</title><title>Scandinavian journal of immunology</title><addtitle>Scand J Immunol</addtitle><description>In this study, we have analysed the phenotypic features of innate/adaptive immunity of patients with localized cutaneous leishmaniasis (LCL), categorized according to their clinical/laboratorial status, including number of lesion (L1; L2–4), days of illness duration (≤60;>60) and positivity in the Montenegro skin test (MT−;MT+). Our findings highlighted a range of phenotypic features observed in patients with LCL (↑%HLA‐DR+ neutrophils; ↑CD8+ HLA‐DR+/CD4+ HLA‐DR+ T cell ratio; ↑HLA‐DR in B lymphocytes, ↑%CD23+ neutrophils, monocytes and B cells; ↑α‐Leishmania IgG and ↑serum + ). Selective changes were observed in L1 (↑%HLA‐DR+ neutrophils, ↑CD8+ HLA‐DR+/CD4+ HLA‐DR+ T cell ratio and ↑serum + ) as compared to L2–4 (↑%CD5− B cells; ↑CD23+ B cells and ↑α‐Leishmania IgG). Whilst ≤60 presented a mixed profile of innate/adaptive immunity (↓%CD28+ neutrophils and ↑%CD4+ T cells), >60 showed a well‐known leishmanicidal events (↑CD8+ T cells; ↑serum + and ↑α‐Leishmania IgG). MT+ patients showed increased putative leishmanicidal capacity (↑%HLA‐DR+ neutrophils; ↑%CD23+ monocytes; ↑CD8+ HLA‐DR+/CD4+ HLA‐DR+ T cell ratio and ↑ serum + ). Overall, a range of immunological biomarkers illustrates the complex immunological network associated with distinct clinical/laboratorial features of LCL with applicability in clinical studies.</description><subject>Adaptive Immunity</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Antigens, CD - blood</subject><subject>Antigens, CD - immunology</subject><subject>B-Lymphocytes - immunology</subject><subject>B-Lymphocytes - parasitology</subject><subject>B-Lymphocytes - pathology</subject><subject>Biomarkers - blood</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Female</subject><subject>HLA-DR Antigens - blood</subject><subject>HLA-DR Antigens - immunology</subject><subject>Humans</subject><subject>Immunity, Innate</subject><subject>Immunophenotyping</subject><subject>Infant</subject><subject>Leishmania braziliensis - immunology</subject><subject>Leishmaniasis, Cutaneous - immunology</subject><subject>Leishmaniasis, Cutaneous - parasitology</subject><subject>Leishmaniasis, Cutaneous - pathology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neutrophils - immunology</subject><subject>Neutrophils - parasitology</subject><subject>Neutrophils - pathology</subject><subject>Nitrates - blood</subject><subject>Nitrates - immunology</subject><subject>Nitrites - blood</subject><subject>Nitrites - immunology</subject><subject>Skin - immunology</subject><subject>Skin - parasitology</subject><subject>Skin - pathology</subject><subject>T-Lymphocytes - immunology</subject><subject>T-Lymphocytes - parasitology</subject><subject>T-Lymphocytes - pathology</subject><issn>0300-9475</issn><issn>1365-3083</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNks2O0zAURi0EYkrhFZAlNmyS8V_iZMFiVJihqIKKAmVnuYlDXRIn2A7TzrPxcDjJ0AUb8CaWfc7nG90LAMQoxmFdHmJM0ySiKKMxQZjEiHCWxccHYHa-eAhmiCIU5YwnF-CJcweEMCWcPgYXhGSEshzPwK_X2nltCg_X0ntlDWwruGya3rTdXpnWnzpdwGslfW-VGy-NkV5BaUp4VcrO659qErQ_QemghOvey_F4o7-ZURy8Ra2NLmQ9miu5a630rdXhYBPwfswONWhlvIO32u_hqg24vlMlXIREo9oArZR2-0YaLZ12T8GjStZOPbv_zsHn6zefFm-j1Yeb5eJqFRUJzrKIcV5QwtKcSIlzWSjEdjxDKc4TpCTPVI7ZLuGU4grjknNWMFYQWpUor7KMlXQOXk65nW1_9Mp50WhXqLqeihIYM5pTTjD6N4pyyniachLQF3-hh7a3JvyICHmEIJSGouYgm6jCts5ZVYnO6kbaU4gSwzCIgxh6Loaei2EYxDgM4hjU5_cP9LtGlWfxT_cD8GoCbnWtTv8dLDbvlsMu-NHkhxlSx7Mv7XeRcsoTsX1_I75-IR-TNdqKLf0N59HTxw</recordid><startdate>201210</startdate><enddate>201210</enddate><creator>Freitas-Teixeira, P. M.</creator><creator>Silveira-Lemos, D.</creator><creator>Giunchetti, R. C.</creator><creator>Baratta-Masini, A.</creator><creator>Mayrink, W.</creator><creator>Peruhype-Magalhães, V.</creator><creator>Rocha, R. D. R.</creator><creator>Campi-Azevedo, A. C.</creator><creator>Teixeira-Carvalho, A.</creator><creator>Martins-Filho, O. A.</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7T5</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>P64</scope><scope>C1K</scope><scope>F1W</scope><scope>H95</scope><scope>H97</scope><scope>L.G</scope><scope>7X8</scope></search><sort><creationdate>201210</creationdate><title>Distinct Pattern of Immunophenotypic Features of Innate and Adaptive Immunity as a Putative Signature of Clinical and Laboratorial Status of Patients with Localized Cutaneous Leishmaniasis</title><author>Freitas-Teixeira, P. M. ; Silveira-Lemos, D. ; Giunchetti, R. C. ; Baratta-Masini, A. ; Mayrink, W. ; Peruhype-Magalhães, V. ; Rocha, R. D. R. ; Campi-Azevedo, A. C. ; Teixeira-Carvalho, A. ; Martins-Filho, O. 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M.</au><au>Silveira-Lemos, D.</au><au>Giunchetti, R. C.</au><au>Baratta-Masini, A.</au><au>Mayrink, W.</au><au>Peruhype-Magalhães, V.</au><au>Rocha, R. D. R.</au><au>Campi-Azevedo, A. C.</au><au>Teixeira-Carvalho, A.</au><au>Martins-Filho, O. A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Distinct Pattern of Immunophenotypic Features of Innate and Adaptive Immunity as a Putative Signature of Clinical and Laboratorial Status of Patients with Localized Cutaneous Leishmaniasis</atitle><jtitle>Scandinavian journal of immunology</jtitle><addtitle>Scand J Immunol</addtitle><date>2012-10</date><risdate>2012</risdate><volume>76</volume><issue>4</issue><spage>421</spage><epage>432</epage><pages>421-432</pages><issn>0300-9475</issn><eissn>1365-3083</eissn><abstract>In this study, we have analysed the phenotypic features of innate/adaptive immunity of patients with localized cutaneous leishmaniasis (LCL), categorized according to their clinical/laboratorial status, including number of lesion (L1; L2–4), days of illness duration (≤60;>60) and positivity in the Montenegro skin test (MT−;MT+). Our findings highlighted a range of phenotypic features observed in patients with LCL (↑%HLA‐DR+ neutrophils; ↑CD8+ HLA‐DR+/CD4+ HLA‐DR+ T cell ratio; ↑HLA‐DR in B lymphocytes, ↑%CD23+ neutrophils, monocytes and B cells; ↑α‐Leishmania IgG and ↑serum + ). Selective changes were observed in L1 (↑%HLA‐DR+ neutrophils, ↑CD8+ HLA‐DR+/CD4+ HLA‐DR+ T cell ratio and ↑serum + ) as compared to L2–4 (↑%CD5− B cells; ↑CD23+ B cells and ↑α‐Leishmania IgG). Whilst ≤60 presented a mixed profile of innate/adaptive immunity (↓%CD28+ neutrophils and ↑%CD4+ T cells), >60 showed a well‐known leishmanicidal events (↑CD8+ T cells; ↑serum + and ↑α‐Leishmania IgG). MT+ patients showed increased putative leishmanicidal capacity (↑%HLA‐DR+ neutrophils; ↑%CD23+ monocytes; ↑CD8+ HLA‐DR+/CD4+ HLA‐DR+ T cell ratio and ↑ serum + ). Overall, a range of immunological biomarkers illustrates the complex immunological network associated with distinct clinical/laboratorial features of LCL with applicability in clinical studies.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>22823491</pmid><doi>10.1111/j.1365-3083.2012.02748.x</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adaptive Immunity Adolescent Adult Aged Aged, 80 and over Antigens, CD - blood Antigens, CD - immunology B-Lymphocytes - immunology B-Lymphocytes - parasitology B-Lymphocytes - pathology Biomarkers - blood Child Child, Preschool Female HLA-DR Antigens - blood HLA-DR Antigens - immunology Humans Immunity, Innate Immunophenotyping Infant Leishmania braziliensis - immunology Leishmaniasis, Cutaneous - immunology Leishmaniasis, Cutaneous - parasitology Leishmaniasis, Cutaneous - pathology Male Middle Aged Neutrophils - immunology Neutrophils - parasitology Neutrophils - pathology Nitrates - blood Nitrates - immunology Nitrites - blood Nitrites - immunology Skin - immunology Skin - parasitology Skin - pathology T-Lymphocytes - immunology T-Lymphocytes - parasitology T-Lymphocytes - pathology |
| title | Distinct Pattern of Immunophenotypic Features of Innate and Adaptive Immunity as a Putative Signature of Clinical and Laboratorial Status of Patients with Localized Cutaneous Leishmaniasis |
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