Genetic structure of hepatitis B and C virus population circulating among healthy and high risk of parenteral contamination individuals in Azerbaijan
Considering that information on genetical features of hepatitis B (HBV) and hepatitis C (HCV) viruses populations, circulating in Azerbaijan remains limited, authors by means of adequate serological and molecular-genetical methods defined major genetical parameters of HBV and HCV, identified among b...
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Veröffentlicht in: | Georgian medical news 2012-10 (211), p.46-49 |
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description | Considering that information on genetical features of hepatitis B (HBV) and hepatitis C (HCV) viruses populations, circulating in Azerbaijan remains limited, authors by means of adequate serological and molecular-genetical methods defined major genetical parameters of HBV and HCV, identified among blood donors living in Azerbaijan and persons from groups with high risk of contamination with HBV and HCV. It was established that population of HBV is presented by dominating "wild" variant of HBV and mutant variants of HBV, defective on ability of producing HBeAg, HBcAg and even HBsAg. Thus more than 90% of HBV isolates belonged to D genotype, and less, than 10% - to A genotype. It is shown that population of HCV is presented by three genotypes: "1", "2" and "3", and the ratio of identification frequencies of these genotypes made approximately 71%:9%:20%, accordingly. |
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It was established that population of HBV is presented by dominating "wild" variant of HBV and mutant variants of HBV, defective on ability of producing HBeAg, HBcAg and even HBsAg. Thus more than 90% of HBV isolates belonged to D genotype, and less, than 10% - to A genotype. 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It was established that population of HBV is presented by dominating "wild" variant of HBV and mutant variants of HBV, defective on ability of producing HBeAg, HBcAg and even HBsAg. Thus more than 90% of HBV isolates belonged to D genotype, and less, than 10% - to A genotype. It is shown that population of HCV is presented by three genotypes: "1", "2" and "3", and the ratio of identification frequencies of these genotypes made approximately 71%:9%:20%, accordingly.</description><subject>Azerbaijan</subject><subject>Blood Donors</subject><subject>Genetics, Population</subject><subject>Hepacivirus - genetics</subject><subject>Hepacivirus - pathogenicity</subject><subject>Hepatitis B - epidemiology</subject><subject>Hepatitis B - genetics</subject><subject>Hepatitis B - transmission</subject><subject>Hepatitis B e Antigens - genetics</subject><subject>Hepatitis B Surface Antigens - genetics</subject><subject>Hepatitis B virus - genetics</subject><subject>Hepatitis B virus - pathogenicity</subject><subject>Hepatitis C - epidemiology</subject><subject>Hepatitis C - genetics</subject><subject>Hepatitis C - transmission</subject><subject>Humans</subject><issn>1512-0112</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kMtOw0AMRWcBolXpL6BZsqkUZ_JclgoKUiUWsI88E6eZkkzCPCqV_-B_CaV4YV_Zvmdxr9gcUohXEUA8Y0vnDtFUaZIVkNywWSxAQFmIOfvekiGvFXfeBuWDJT40vKURvfba8QeOpuYbftQ2OD4OY-imy2C40ladtdlz7Iept4Sdb09nQ6v3LbfaffzSRrRkPFnsuBqMx16bP4Y2tT7qOmDnJs3XX2Ql6gOaW3bdTEtaXuaCvT09vm-eV7vX7ctmvVuNEGd-laOQKCDKpCzLBEWiCpQCoEjzREoZg2zyTESqVkVDaZwrJRqQJMtG5VCLBbv_o452-AzkfNVrp6jr0NAQXAWQiDIqkimsBbu7vAbZU12NVvdoT9V_kOIHuwZzAg</recordid><startdate>201210</startdate><enddate>201210</enddate><creator>Mamedov, M K</creator><creator>Dadasheva, A E</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>201210</creationdate><title>Genetic structure of hepatitis B and C virus population circulating among healthy and high risk of parenteral contamination individuals in Azerbaijan</title><author>Mamedov, M K ; Dadasheva, A E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p126t-7a3ba3106bb994a34c8ab3118574bbb21bf7630cdc8fe527cc3f1beb9fc71d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>rus</language><creationdate>2012</creationdate><topic>Azerbaijan</topic><topic>Blood Donors</topic><topic>Genetics, Population</topic><topic>Hepacivirus - genetics</topic><topic>Hepacivirus - pathogenicity</topic><topic>Hepatitis B - epidemiology</topic><topic>Hepatitis B - genetics</topic><topic>Hepatitis B - transmission</topic><topic>Hepatitis B e Antigens - genetics</topic><topic>Hepatitis B Surface Antigens - genetics</topic><topic>Hepatitis B virus - genetics</topic><topic>Hepatitis B virus - pathogenicity</topic><topic>Hepatitis C - epidemiology</topic><topic>Hepatitis C - genetics</topic><topic>Hepatitis C - transmission</topic><topic>Humans</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mamedov, M K</creatorcontrib><creatorcontrib>Dadasheva, A E</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Georgian medical news</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mamedov, M K</au><au>Dadasheva, A E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genetic structure of hepatitis B and C virus population circulating among healthy and high risk of parenteral contamination individuals in Azerbaijan</atitle><jtitle>Georgian medical news</jtitle><addtitle>Georgian Med News</addtitle><date>2012-10</date><risdate>2012</risdate><issue>211</issue><spage>46</spage><epage>49</epage><pages>46-49</pages><issn>1512-0112</issn><abstract>Considering that information on genetical features of hepatitis B (HBV) and hepatitis C (HCV) viruses populations, circulating in Azerbaijan remains limited, authors by means of adequate serological and molecular-genetical methods defined major genetical parameters of HBV and HCV, identified among blood donors living in Azerbaijan and persons from groups with high risk of contamination with HBV and HCV. It was established that population of HBV is presented by dominating "wild" variant of HBV and mutant variants of HBV, defective on ability of producing HBeAg, HBcAg and even HBsAg. Thus more than 90% of HBV isolates belonged to D genotype, and less, than 10% - to A genotype. It is shown that population of HCV is presented by three genotypes: "1", "2" and "3", and the ratio of identification frequencies of these genotypes made approximately 71%:9%:20%, accordingly.</abstract><cop>Georgia (Republic)</cop><pmid>23131983</pmid><tpages>4</tpages></addata></record> |
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subjects | Azerbaijan Blood Donors Genetics, Population Hepacivirus - genetics Hepacivirus - pathogenicity Hepatitis B - epidemiology Hepatitis B - genetics Hepatitis B - transmission Hepatitis B e Antigens - genetics Hepatitis B Surface Antigens - genetics Hepatitis B virus - genetics Hepatitis B virus - pathogenicity Hepatitis C - epidemiology Hepatitis C - genetics Hepatitis C - transmission Humans |
title | Genetic structure of hepatitis B and C virus population circulating among healthy and high risk of parenteral contamination individuals in Azerbaijan |
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