Curcumin Protects Against Regional Myocardial Ischemia/Reperfusion Injury Through Activation of RISK/GSK-3β and Inhibition of p38 MAPK and JNK

Background: Curcumin, the active ingredient of turmeric (Curcuma longa), is known to have anti-inflammatory and antioxidative properties. The present study was aimed to determine the effect of curcumin in regional myocardial ischemia/reperfusion (I/R) injury and its underlying mechanisms involving t...

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Veröffentlicht in:	Journal of cardiovascular pharmacology and therapeutics 2012-12, Vol.17 (4), p.387-394
Hauptverfasser:	Jeong, Cheol-Won, Yoo, Kyung Yeon, Lee, Seong Heon, Jeong, Hye Jin, Lee, Cha Sup, Kim, Seok Jai
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents, Non-Steroidal - antagonists & inhibitors Anti-Inflammatory Agents, Non-Steroidal - therapeutic use Antioxidants - chemistry Antioxidants - therapeutic use Cardiotonic Agents - antagonists & inhibitors Cardiotonic Agents - therapeutic use Curcumin - chemistry Curcumin - therapeutic use Drug Therapy, Combination Enzyme Inhibitors - adverse effects Enzyme Inhibitors - therapeutic use Glycogen Synthase Kinase 3 - antagonists & inhibitors Glycogen Synthase Kinase 3 - chemistry Glycogen Synthase Kinase 3 - metabolism Glycogen Synthase Kinase 3 beta Heart Ventricles - drug effects Heart Ventricles - enzymology Heart Ventricles - pathology Indoles - therapeutic use Male Maleimides - therapeutic use MAP Kinase Signaling System - drug effects Myocardial Infarction - etiology Myocardial Infarction - pathology Myocardial Infarction - prevention & control Myocardial Reperfusion Injury - enzymology Myocardial Reperfusion Injury - metabolism Myocardial Reperfusion Injury - pathology Myocardial Reperfusion Injury - prevention & control Phosphatidylinositol 3-Kinase - antagonists & inhibitors Phosphatidylinositol 3-Kinase - metabolism Phosphorylation - drug effects Protein Processing, Post-Translational - drug effects Proto-Oncogene Proteins c-akt - antagonists & inhibitors Proto-Oncogene Proteins c-akt - metabolism Rats Rats, Sprague-Dawley
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