Chemical Analysis of C‑Reactive Protein Synthesized by Human Aortic Endothelial Cells Under Oxidative Stress

C-Reactive protein (CRP) is a clinical biomarker of inflammation, and high levels of CRP correlate with cardiovascular disease. The objectives of this study were to test our hypothesis that oxidized low-density lipoprotein (ox-LDL) induces the release of CRP from human aortic endothelial cells (HAEC...

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Veröffentlicht in:	Analytical chemistry (Washington) 2012-11, Vol.84 (21), p.9646-9654
Hauptverfasser:	Tsai, Ming-Hua, Chang, Chia-Liang, Yu, Yu-San, Lin, Ting-Yu, Chong, Chin-Pong, Lin, You-Sian, Su, Mei-Yu, Yang, Jian-Ying, Shu, Ting-Yu, Lu, Xuhai, Chen, Chu-Huang, Liu, Mine-Yine
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Analytical chemistry Aorta - cytology Biochemistry Biomarkers C-Reactive Protein - biosynthesis C-Reactive Protein - chemistry C-Reactive Protein - genetics C-Reactive Protein - isolation & purification Chemistry Chromatographic methods and physical methods associated with chromatography Chromatography Endothelial Cells - drug effects Endothelial Cells - metabolism Exact sciences and technology Humans Lipoproteins, LDL - pharmacology Low density lipoprotein Other chromatographic methods Oxidative stress Oxidative Stress - drug effects Protein synthesis RNA, Messenger - genetics RNA, Messenger - metabolism RNA-protein interactions Spectrometric and optical methods
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