Corticosteroids and antigen avoidance decrease airway smooth muscle mass in an equine asthma model
Recent studies suggest that airway smooth muscle remodeling is an early event in the course of asthma. Little is known of the effects of long-term antigen avoidance and inhaled corticosteroids on chronically established airway remodeling. We sought to measure the effects of inhaled corticosteroids a...
Gespeichert in:
| Veröffentlicht in: | American journal of respiratory cell and molecular biology 2012-11, Vol.47 (5), p.589-596 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 596 |
|---|---|
| container_issue | 5 |
| container_start_page | 589 |
| container_title | American journal of respiratory cell and molecular biology |
| container_volume | 47 |
| creator | Leclere, Mathilde Lavoie-Lamoureux, Anouk Joubert, Philippe Relave, Fabien Setlakwe, Emilie Lanctot Beauchamp, Guy Couture, Christian Martin, James G Lavoie, Jean-Pierre |
| description | Recent studies suggest that airway smooth muscle remodeling is an early event in the course of asthma. Little is known of the effects of long-term antigen avoidance and inhaled corticosteroids on chronically established airway remodeling. We sought to measure the effects of inhaled corticosteroids and antigen avoidance on airway remodeling in the peripheral airways of horses with heaves, a naturally occurring asthma-like disease. Heaves-affected adult horses with ongoing airway inflammation and bronchoconstriction were treated with fluticasone propionate (with and without concurrent antigen avoidance) (n = 6) or with antigen avoidance alone (n = 5). Lung function and bronchoalveolar lavage were performed at multiple time points, and peripheral lung biopsies were collected before and after 6 and 12 months of treatment. Lung function improved more quickly with inhaled corticosteroids, but eventually normalized in both groups. Inflammation was better controlled with antigen avoidance. During the study period, corrected smooth muscle mass decreased from 12.1 ± 2.8 × 10(-3) and 11.3 ± 1.2 × 10(-3) to 8.3 ± 1.4 × 10(-3) and 7.9 ± 1.0 × 10(-3) in the antigen avoidance and fluticasone groups, respectively (P = 0.03). At 6 months, smooth muscle mass was significantly smaller compared with baseline only in the fluticasone-treated animals. The subepithelial collagen area was lower at 12 months than at baseline in both groups. During the study period, airway smooth muscle remodeling decreased by approximately 30% in both groups, although the decrease was faster in horses receiving inhaled corticosteroids. Inhaled corticosteroids may accelerate the reversal of smooth muscle remodeling, even if airway inflammation is better controlled with antigen avoidance. |
| doi_str_mv | 10.1165/rcmb.2011-0363OC |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1139626157</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1139626157</sourcerecordid><originalsourceid>FETCH-LOGICAL-c327t-e549a9c128c70d9bdb963d8841ddd2846a79db65558d81abd39374688978dc693</originalsourceid><addsrcrecordid>eNpdkE1LxDAQhoMorq7ePUnAi5dqJmnT5CjFLxC86DmkSdbt0jRr0ir7782yqwcPwwzDM8PLg9AFkBsAXt1G49sbSgAKwjh7bQ7QCVSsKkop5GGeSVkWUJVyhk5TWhECVAAcoxmlNQXB6AlqmxDHzoQ0uhg6m7AebK6x-3AD1l95pQfjsHUmOp0c1l381hucfAjjEvspmd5hr1PCXeYH7D6nbshYGpdeYx-s68_Q0UL3yZ3v-xy9P9y_NU_Fy-vjc3P3UhhG67FwOaeWJkc0NbGyta3kzApRgrWWipLrWtqWV1UlrADdWiZZXXIhZC2s4ZLN0fXu7zqGz8mlUfkuGdf3enBhSgqASU45VHVGr_6hqzDFIadTQLmoQYAQmSI7ysSQUnQLtY6d13GjgKitf7X1r7b-1c5_PrncP55a7-zfwa9w9gPmNYGL</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1268718188</pqid></control><display><type>article</type><title>Corticosteroids and antigen avoidance decrease airway smooth muscle mass in an equine asthma model</title><source>MEDLINE</source><source>Journals@Ovid Complete</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Leclere, Mathilde ; Lavoie-Lamoureux, Anouk ; Joubert, Philippe ; Relave, Fabien ; Setlakwe, Emilie Lanctot ; Beauchamp, Guy ; Couture, Christian ; Martin, James G ; Lavoie, Jean-Pierre</creator><creatorcontrib>Leclere, Mathilde ; Lavoie-Lamoureux, Anouk ; Joubert, Philippe ; Relave, Fabien ; Setlakwe, Emilie Lanctot ; Beauchamp, Guy ; Couture, Christian ; Martin, James G ; Lavoie, Jean-Pierre</creatorcontrib><description>Recent studies suggest that airway smooth muscle remodeling is an early event in the course of asthma. Little is known of the effects of long-term antigen avoidance and inhaled corticosteroids on chronically established airway remodeling. We sought to measure the effects of inhaled corticosteroids and antigen avoidance on airway remodeling in the peripheral airways of horses with heaves, a naturally occurring asthma-like disease. Heaves-affected adult horses with ongoing airway inflammation and bronchoconstriction were treated with fluticasone propionate (with and without concurrent antigen avoidance) (n = 6) or with antigen avoidance alone (n = 5). Lung function and bronchoalveolar lavage were performed at multiple time points, and peripheral lung biopsies were collected before and after 6 and 12 months of treatment. Lung function improved more quickly with inhaled corticosteroids, but eventually normalized in both groups. Inflammation was better controlled with antigen avoidance. During the study period, corrected smooth muscle mass decreased from 12.1 ± 2.8 × 10(-3) and 11.3 ± 1.2 × 10(-3) to 8.3 ± 1.4 × 10(-3) and 7.9 ± 1.0 × 10(-3) in the antigen avoidance and fluticasone groups, respectively (P = 0.03). At 6 months, smooth muscle mass was significantly smaller compared with baseline only in the fluticasone-treated animals. The subepithelial collagen area was lower at 12 months than at baseline in both groups. During the study period, airway smooth muscle remodeling decreased by approximately 30% in both groups, although the decrease was faster in horses receiving inhaled corticosteroids. Inhaled corticosteroids may accelerate the reversal of smooth muscle remodeling, even if airway inflammation is better controlled with antigen avoidance.</description><identifier>ISSN: 1044-1549</identifier><identifier>EISSN: 1535-4989</identifier><identifier>DOI: 10.1165/rcmb.2011-0363OC</identifier><identifier>PMID: 22721832</identifier><language>eng</language><publisher>United States: American Thoracic Society</publisher><subject>Administration, Inhalation ; Adrenal Cortex Hormones - administration & dosage ; Adrenal Cortex Hormones - pharmacology ; Airway Remodeling - drug effects ; Airway Resistance ; Androstadienes - administration & dosage ; Androstadienes - pharmacology ; Animals ; Antigens, Plant - immunology ; Asthma - drug therapy ; Asthma - immunology ; Asthma - pathology ; Asthma - veterinary ; Bronchioles - immunology ; Bronchioles - pathology ; Bronchoalveolar Lavage Fluid ; Bronchodilator Agents - administration & dosage ; Bronchodilator Agents - pharmacology ; Cell Proliferation ; Collagen - metabolism ; Cytokines - metabolism ; Fluticasone ; Horse Diseases - drug therapy ; Horse Diseases - immunology ; Horse Diseases - pathology ; Horses ; Inflammation Mediators - metabolism ; Lung - drug effects ; Lung - pathology ; Lung - physiopathology ; Monocytes - metabolism ; Muscle, Smooth - pathology ; Organ Size - drug effects ; Proliferating Cell Nuclear Antigen - metabolism ; Respiratory Function Tests ; Respiratory Mucosa - metabolism ; Respiratory Mucosa - pathology ; Treatment Outcome</subject><ispartof>American journal of respiratory cell and molecular biology, 2012-11, Vol.47 (5), p.589-596</ispartof><rights>Copyright American Thoracic Society Nov 2012</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c327t-e549a9c128c70d9bdb963d8841ddd2846a79db65558d81abd39374688978dc693</citedby><cites>FETCH-LOGICAL-c327t-e549a9c128c70d9bdb963d8841ddd2846a79db65558d81abd39374688978dc693</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22721832$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Leclere, Mathilde</creatorcontrib><creatorcontrib>Lavoie-Lamoureux, Anouk</creatorcontrib><creatorcontrib>Joubert, Philippe</creatorcontrib><creatorcontrib>Relave, Fabien</creatorcontrib><creatorcontrib>Setlakwe, Emilie Lanctot</creatorcontrib><creatorcontrib>Beauchamp, Guy</creatorcontrib><creatorcontrib>Couture, Christian</creatorcontrib><creatorcontrib>Martin, James G</creatorcontrib><creatorcontrib>Lavoie, Jean-Pierre</creatorcontrib><title>Corticosteroids and antigen avoidance decrease airway smooth muscle mass in an equine asthma model</title><title>American journal of respiratory cell and molecular biology</title><addtitle>Am J Respir Cell Mol Biol</addtitle><description>Recent studies suggest that airway smooth muscle remodeling is an early event in the course of asthma. Little is known of the effects of long-term antigen avoidance and inhaled corticosteroids on chronically established airway remodeling. We sought to measure the effects of inhaled corticosteroids and antigen avoidance on airway remodeling in the peripheral airways of horses with heaves, a naturally occurring asthma-like disease. Heaves-affected adult horses with ongoing airway inflammation and bronchoconstriction were treated with fluticasone propionate (with and without concurrent antigen avoidance) (n = 6) or with antigen avoidance alone (n = 5). Lung function and bronchoalveolar lavage were performed at multiple time points, and peripheral lung biopsies were collected before and after 6 and 12 months of treatment. Lung function improved more quickly with inhaled corticosteroids, but eventually normalized in both groups. Inflammation was better controlled with antigen avoidance. During the study period, corrected smooth muscle mass decreased from 12.1 ± 2.8 × 10(-3) and 11.3 ± 1.2 × 10(-3) to 8.3 ± 1.4 × 10(-3) and 7.9 ± 1.0 × 10(-3) in the antigen avoidance and fluticasone groups, respectively (P = 0.03). At 6 months, smooth muscle mass was significantly smaller compared with baseline only in the fluticasone-treated animals. The subepithelial collagen area was lower at 12 months than at baseline in both groups. During the study period, airway smooth muscle remodeling decreased by approximately 30% in both groups, although the decrease was faster in horses receiving inhaled corticosteroids. Inhaled corticosteroids may accelerate the reversal of smooth muscle remodeling, even if airway inflammation is better controlled with antigen avoidance.</description><subject>Administration, Inhalation</subject><subject>Adrenal Cortex Hormones - administration & dosage</subject><subject>Adrenal Cortex Hormones - pharmacology</subject><subject>Airway Remodeling - drug effects</subject><subject>Airway Resistance</subject><subject>Androstadienes - administration & dosage</subject><subject>Androstadienes - pharmacology</subject><subject>Animals</subject><subject>Antigens, Plant - immunology</subject><subject>Asthma - drug therapy</subject><subject>Asthma - immunology</subject><subject>Asthma - pathology</subject><subject>Asthma - veterinary</subject><subject>Bronchioles - immunology</subject><subject>Bronchioles - pathology</subject><subject>Bronchoalveolar Lavage Fluid</subject><subject>Bronchodilator Agents - administration & dosage</subject><subject>Bronchodilator Agents - pharmacology</subject><subject>Cell Proliferation</subject><subject>Collagen - metabolism</subject><subject>Cytokines - metabolism</subject><subject>Fluticasone</subject><subject>Horse Diseases - drug therapy</subject><subject>Horse Diseases - immunology</subject><subject>Horse Diseases - pathology</subject><subject>Horses</subject><subject>Inflammation Mediators - metabolism</subject><subject>Lung - drug effects</subject><subject>Lung - pathology</subject><subject>Lung - physiopathology</subject><subject>Monocytes - metabolism</subject><subject>Muscle, Smooth - pathology</subject><subject>Organ Size - drug effects</subject><subject>Proliferating Cell Nuclear Antigen - metabolism</subject><subject>Respiratory Function Tests</subject><subject>Respiratory Mucosa - metabolism</subject><subject>Respiratory Mucosa - pathology</subject><subject>Treatment Outcome</subject><issn>1044-1549</issn><issn>1535-4989</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNpdkE1LxDAQhoMorq7ePUnAi5dqJmnT5CjFLxC86DmkSdbt0jRr0ir7782yqwcPwwzDM8PLg9AFkBsAXt1G49sbSgAKwjh7bQ7QCVSsKkop5GGeSVkWUJVyhk5TWhECVAAcoxmlNQXB6AlqmxDHzoQ0uhg6m7AebK6x-3AD1l95pQfjsHUmOp0c1l381hucfAjjEvspmd5hr1PCXeYH7D6nbshYGpdeYx-s68_Q0UL3yZ3v-xy9P9y_NU_Fy-vjc3P3UhhG67FwOaeWJkc0NbGyta3kzApRgrWWipLrWtqWV1UlrADdWiZZXXIhZC2s4ZLN0fXu7zqGz8mlUfkuGdf3enBhSgqASU45VHVGr_6hqzDFIadTQLmoQYAQmSI7ysSQUnQLtY6d13GjgKitf7X1r7b-1c5_PrncP55a7-zfwa9w9gPmNYGL</recordid><startdate>201211</startdate><enddate>201211</enddate><creator>Leclere, Mathilde</creator><creator>Lavoie-Lamoureux, Anouk</creator><creator>Joubert, Philippe</creator><creator>Relave, Fabien</creator><creator>Setlakwe, Emilie Lanctot</creator><creator>Beauchamp, Guy</creator><creator>Couture, Christian</creator><creator>Martin, James G</creator><creator>Lavoie, Jean-Pierre</creator><general>American Thoracic Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7TM</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>S0X</scope><scope>7X8</scope></search><sort><creationdate>201211</creationdate><title>Corticosteroids and antigen avoidance decrease airway smooth muscle mass in an equine asthma model</title><author>Leclere, Mathilde ; Lavoie-Lamoureux, Anouk ; Joubert, Philippe ; Relave, Fabien ; Setlakwe, Emilie Lanctot ; Beauchamp, Guy ; Couture, Christian ; Martin, James G ; Lavoie, Jean-Pierre</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c327t-e549a9c128c70d9bdb963d8841ddd2846a79db65558d81abd39374688978dc693</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Administration, Inhalation</topic><topic>Adrenal Cortex Hormones - administration & dosage</topic><topic>Adrenal Cortex Hormones - pharmacology</topic><topic>Airway Remodeling - drug effects</topic><topic>Airway Resistance</topic><topic>Androstadienes - administration & dosage</topic><topic>Androstadienes - pharmacology</topic><topic>Animals</topic><topic>Antigens, Plant - immunology</topic><topic>Asthma - drug therapy</topic><topic>Asthma - immunology</topic><topic>Asthma - pathology</topic><topic>Asthma - veterinary</topic><topic>Bronchioles - immunology</topic><topic>Bronchioles - pathology</topic><topic>Bronchoalveolar Lavage Fluid</topic><topic>Bronchodilator Agents - administration & dosage</topic><topic>Bronchodilator Agents - pharmacology</topic><topic>Cell Proliferation</topic><topic>Collagen - metabolism</topic><topic>Cytokines - metabolism</topic><topic>Fluticasone</topic><topic>Horse Diseases - drug therapy</topic><topic>Horse Diseases - immunology</topic><topic>Horse Diseases - pathology</topic><topic>Horses</topic><topic>Inflammation Mediators - metabolism</topic><topic>Lung - drug effects</topic><topic>Lung - pathology</topic><topic>Lung - physiopathology</topic><topic>Monocytes - metabolism</topic><topic>Muscle, Smooth - pathology</topic><topic>Organ Size - drug effects</topic><topic>Proliferating Cell Nuclear Antigen - metabolism</topic><topic>Respiratory Function Tests</topic><topic>Respiratory Mucosa - metabolism</topic><topic>Respiratory Mucosa - pathology</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Leclere, Mathilde</creatorcontrib><creatorcontrib>Lavoie-Lamoureux, Anouk</creatorcontrib><creatorcontrib>Joubert, Philippe</creatorcontrib><creatorcontrib>Relave, Fabien</creatorcontrib><creatorcontrib>Setlakwe, Emilie Lanctot</creatorcontrib><creatorcontrib>Beauchamp, Guy</creatorcontrib><creatorcontrib>Couture, Christian</creatorcontrib><creatorcontrib>Martin, James G</creatorcontrib><creatorcontrib>Lavoie, Jean-Pierre</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of respiratory cell and molecular biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Leclere, Mathilde</au><au>Lavoie-Lamoureux, Anouk</au><au>Joubert, Philippe</au><au>Relave, Fabien</au><au>Setlakwe, Emilie Lanctot</au><au>Beauchamp, Guy</au><au>Couture, Christian</au><au>Martin, James G</au><au>Lavoie, Jean-Pierre</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Corticosteroids and antigen avoidance decrease airway smooth muscle mass in an equine asthma model</atitle><jtitle>American journal of respiratory cell and molecular biology</jtitle><addtitle>Am J Respir Cell Mol Biol</addtitle><date>2012-11</date><risdate>2012</risdate><volume>47</volume><issue>5</issue><spage>589</spage><epage>596</epage><pages>589-596</pages><issn>1044-1549</issn><eissn>1535-4989</eissn><abstract>Recent studies suggest that airway smooth muscle remodeling is an early event in the course of asthma. Little is known of the effects of long-term antigen avoidance and inhaled corticosteroids on chronically established airway remodeling. We sought to measure the effects of inhaled corticosteroids and antigen avoidance on airway remodeling in the peripheral airways of horses with heaves, a naturally occurring asthma-like disease. Heaves-affected adult horses with ongoing airway inflammation and bronchoconstriction were treated with fluticasone propionate (with and without concurrent antigen avoidance) (n = 6) or with antigen avoidance alone (n = 5). Lung function and bronchoalveolar lavage were performed at multiple time points, and peripheral lung biopsies were collected before and after 6 and 12 months of treatment. Lung function improved more quickly with inhaled corticosteroids, but eventually normalized in both groups. Inflammation was better controlled with antigen avoidance. During the study period, corrected smooth muscle mass decreased from 12.1 ± 2.8 × 10(-3) and 11.3 ± 1.2 × 10(-3) to 8.3 ± 1.4 × 10(-3) and 7.9 ± 1.0 × 10(-3) in the antigen avoidance and fluticasone groups, respectively (P = 0.03). At 6 months, smooth muscle mass was significantly smaller compared with baseline only in the fluticasone-treated animals. The subepithelial collagen area was lower at 12 months than at baseline in both groups. During the study period, airway smooth muscle remodeling decreased by approximately 30% in both groups, although the decrease was faster in horses receiving inhaled corticosteroids. Inhaled corticosteroids may accelerate the reversal of smooth muscle remodeling, even if airway inflammation is better controlled with antigen avoidance.</abstract><cop>United States</cop><pub>American Thoracic Society</pub><pmid>22721832</pmid><doi>10.1165/rcmb.2011-0363OC</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1044-1549 |
| ispartof | American journal of respiratory cell and molecular biology, 2012-11, Vol.47 (5), p.589-596 |
| issn | 1044-1549 1535-4989 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1139626157 |
| source | MEDLINE; Journals@Ovid Complete; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Administration, Inhalation Adrenal Cortex Hormones - administration & dosage Adrenal Cortex Hormones - pharmacology Airway Remodeling - drug effects Airway Resistance Androstadienes - administration & dosage Androstadienes - pharmacology Animals Antigens, Plant - immunology Asthma - drug therapy Asthma - immunology Asthma - pathology Asthma - veterinary Bronchioles - immunology Bronchioles - pathology Bronchoalveolar Lavage Fluid Bronchodilator Agents - administration & dosage Bronchodilator Agents - pharmacology Cell Proliferation Collagen - metabolism Cytokines - metabolism Fluticasone Horse Diseases - drug therapy Horse Diseases - immunology Horse Diseases - pathology Horses Inflammation Mediators - metabolism Lung - drug effects Lung - pathology Lung - physiopathology Monocytes - metabolism Muscle, Smooth - pathology Organ Size - drug effects Proliferating Cell Nuclear Antigen - metabolism Respiratory Function Tests Respiratory Mucosa - metabolism Respiratory Mucosa - pathology Treatment Outcome |
| title | Corticosteroids and antigen avoidance decrease airway smooth muscle mass in an equine asthma model |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T15%3A00%3A12IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Corticosteroids%20and%20antigen%20avoidance%20decrease%20airway%20smooth%20muscle%20mass%20in%20an%20equine%20asthma%20model&rft.jtitle=American%20journal%20of%20respiratory%20cell%20and%20molecular%20biology&rft.au=Leclere,%20Mathilde&rft.date=2012-11&rft.volume=47&rft.issue=5&rft.spage=589&rft.epage=596&rft.pages=589-596&rft.issn=1044-1549&rft.eissn=1535-4989&rft_id=info:doi/10.1165/rcmb.2011-0363OC&rft_dat=%3Cproquest_cross%3E1139626157%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1268718188&rft_id=info:pmid/22721832&rfr_iscdi=true |