Differential association of proinflammatory cytokines with left ventricular diastolic dysfunction in subjects with and without continuous ambulatory peritoneal dialysis
Abstract Background and aims The association between inflammation and left ventricular (LV) diastolic dysfunction in continuous ambulatory peritoneal dialysis (CAPD) and non-CAPD patients is not established. The objective of this study was to test the above association and whether inflammation inter...
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| Veröffentlicht in: | Nutrition, metabolism, and cardiovascular diseases metabolism, and cardiovascular diseases, 2012-11, Vol.22 (11), p.974-980 |
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| creator | Lee, J.-K Lin, H.-H Tsai, C.-T Chen, J.-J Kuo, C.-C Lien, Y.-C Lin, J.-W Huang, J.-W Hwang, S.-W Hwang, J.-J Tseng, C.-D Chiang, F.-T Wu, C.-K |
| description | Abstract Background and aims The association between inflammation and left ventricular (LV) diastolic dysfunction in continuous ambulatory peritoneal dialysis (CAPD) and non-CAPD patients is not established. The objective of this study was to test the above association and whether inflammation interacts with CAPD to increase LV diastolic dysfunction risks. Methods and results 120 subjects with normal creatinine levels and 101 CAPD patients were recruited. Echocardiographic parameters were assessed in all patients. The participants were classified as having LV diastolic dysfunction by echocardiographic findings including mitral inflow E / A ratio 220 cm/s, or decreased peak annular early diastolic velocity in tissue Doppler imaging. Blood was sampled at the baseline for measurement of inflammation markers, including tissue necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6). Subjects with LV diastolic dysfunction had higher proinflammation cytokines levels in both groups. Inflamed markers correlated significantly with echocardiography parameters for LV diastolic dysfunction in patients receiving CAPD. In a multivariate regression analysis adjusting for all the factors associated with LV diastolic dysfunction, inflammation is still significantly associated with left ventricular diastolic dysfunction (TNF-alpha, OR: 2.6, 95% CI: 2.0–3.35, p |
| doi_str_mv | 10.1016/j.numecd.2011.01.001 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1139622797</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0939475311000056</els_id><sourcerecordid>1139622797</sourcerecordid><originalsourceid>FETCH-LOGICAL-c487t-65ba9dd3a250c14c569bee870c834fa5bf5fc39834d39030723fba3a595233c33</originalsourceid><addsrcrecordid>eNqFUsuO1DAQjBCIHRb-AIGPXDK043gyuSCh5SmtxGHZs-U4behZxx5sZ1H-iM_E84ADF6SWbEtV1eWurqrnHNYc-Ob1bu3nCc24boDzNZQC_qBacdlDLbqmf1itoBd93XZSXFRPUtoBiA5E-7i6aAqq6aRcVb_ekbUY0WfSjumUgiGdKXgWLNvHQN46PU06h7gws-RwRx4T-0n5O3NoM7sv1EhmdjqykXTKwZFh45Ls7M1RiDxL87BDk8887cfjJcyZmVA6-znMielpKCrHRnuMlIPHYqlouiVRelo9stolfHY-L6vbD--_Xn2qr798_Hz19ro27bbL9UYOuh9HoRsJhrdGbvoBcduB2YrWajlYaY3oy2MUPQjoGmEHLbTsZSOEEeKyenXSLZ__MWPKaqJk0DntsbhUnIt-0zRd3xVoe4KaGFKKaNU-0qTjojioQ0Zqp04ZqUNGCkoBL7QX5w7zMOH4l_QnlAJ4eQJYHZT-Fimp25uiIAFgy0ucBfHmhMAyiXvCqJIh9AZHimXOagz0Pw__ChhHnox2d7hg2oU5-jJlxVVqFKibwyYdFonz4gHkRvwGI23IoQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1139622797</pqid></control><display><type>article</type><title>Differential association of proinflammatory cytokines with left ventricular diastolic dysfunction in subjects with and without continuous ambulatory peritoneal dialysis</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Lee, J.-K ; Lin, H.-H ; Tsai, C.-T ; Chen, J.-J ; Kuo, C.-C ; Lien, Y.-C ; Lin, J.-W ; Huang, J.-W ; Hwang, S.-W ; Hwang, J.-J ; Tseng, C.-D ; Chiang, F.-T ; Wu, C.-K</creator><creatorcontrib>Lee, J.-K ; Lin, H.-H ; Tsai, C.-T ; Chen, J.-J ; Kuo, C.-C ; Lien, Y.-C ; Lin, J.-W ; Huang, J.-W ; Hwang, S.-W ; Hwang, J.-J ; Tseng, C.-D ; Chiang, F.-T ; Wu, C.-K</creatorcontrib><description>Abstract Background and aims The association between inflammation and left ventricular (LV) diastolic dysfunction in continuous ambulatory peritoneal dialysis (CAPD) and non-CAPD patients is not established. The objective of this study was to test the above association and whether inflammation interacts with CAPD to increase LV diastolic dysfunction risks. Methods and results 120 subjects with normal creatinine levels and 101 CAPD patients were recruited. Echocardiographic parameters were assessed in all patients. The participants were classified as having LV diastolic dysfunction by echocardiographic findings including mitral inflow E / A ratio < 1, deceleration time > 220 cm/s, or decreased peak annular early diastolic velocity in tissue Doppler imaging. Blood was sampled at the baseline for measurement of inflammation markers, including tissue necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6). Subjects with LV diastolic dysfunction had higher proinflammation cytokines levels in both groups. Inflamed markers correlated significantly with echocardiography parameters for LV diastolic dysfunction in patients receiving CAPD. In a multivariate regression analysis adjusting for all the factors associated with LV diastolic dysfunction, inflammation is still significantly associated with left ventricular diastolic dysfunction (TNF-alpha, OR: 2.6, 95% CI: 2.0–3.35, p < 0.001; IL-6, OR: 1.26, 95% CI: 1.25–1.26, p = 0.01). In addition, the interaction of CAPD and inflammation significantly contributed to the development of LV diastolic dysfunction (CAPD∗ TNF-α: OR: 1.45, 95% CI: 1.13–1.79, P = 0.004). Conclusion We found inflammation plays a vital role for LV diastolic dysfunction especially in CAPD patients. A synergistic effect between CAPD and inflammation, especially TNF-α, would further aggravate LV diastolic dysfunction.</description><identifier>ISSN: 0939-4753</identifier><identifier>EISSN: 1590-3729</identifier><identifier>DOI: 10.1016/j.numecd.2011.01.001</identifier><identifier>PMID: 21592755</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Aged ; Aged, 80 and over ; Biomarkers - blood ; blood ; Cardiovascular ; Case-Control Studies ; Continuous ambulatory peritoneal dialysis ; creatinine ; Creatinine - blood ; dialysis ; echocardiography ; Echocardiography, Doppler - methods ; Female ; Humans ; image analysis ; Inflammation ; Inflammation - complications ; Inflammation - physiopathology ; interleukin-6 ; Interleukin-6 - blood ; Left ventricular diastolic dysfunction ; Logistic Models ; Male ; Middle Aged ; Multivariate Analysis ; patients ; Peritoneal Dialysis, Continuous Ambulatory ; regression analysis ; risk ; Risk Factors ; synergism ; tumor necrosis factor-alpha ; Tumor Necrosis Factor-alpha - blood ; Ventricular Dysfunction, Left - complications ; Ventricular Dysfunction, Left - physiopathology</subject><ispartof>Nutrition, metabolism, and cardiovascular diseases, 2012-11, Vol.22 (11), p.974-980</ispartof><rights>Elsevier B.V.</rights><rights>2011 Elsevier B.V.</rights><rights>Copyright © 2011 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c487t-65ba9dd3a250c14c569bee870c834fa5bf5fc39834d39030723fba3a595233c33</citedby><cites>FETCH-LOGICAL-c487t-65ba9dd3a250c14c569bee870c834fa5bf5fc39834d39030723fba3a595233c33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0939475311000056$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21592755$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, J.-K</creatorcontrib><creatorcontrib>Lin, H.-H</creatorcontrib><creatorcontrib>Tsai, C.-T</creatorcontrib><creatorcontrib>Chen, J.-J</creatorcontrib><creatorcontrib>Kuo, C.-C</creatorcontrib><creatorcontrib>Lien, Y.-C</creatorcontrib><creatorcontrib>Lin, J.-W</creatorcontrib><creatorcontrib>Huang, J.-W</creatorcontrib><creatorcontrib>Hwang, S.-W</creatorcontrib><creatorcontrib>Hwang, J.-J</creatorcontrib><creatorcontrib>Tseng, C.-D</creatorcontrib><creatorcontrib>Chiang, F.-T</creatorcontrib><creatorcontrib>Wu, C.-K</creatorcontrib><title>Differential association of proinflammatory cytokines with left ventricular diastolic dysfunction in subjects with and without continuous ambulatory peritoneal dialysis</title><title>Nutrition, metabolism, and cardiovascular diseases</title><addtitle>Nutr Metab Cardiovasc Dis</addtitle><description>Abstract Background and aims The association between inflammation and left ventricular (LV) diastolic dysfunction in continuous ambulatory peritoneal dialysis (CAPD) and non-CAPD patients is not established. The objective of this study was to test the above association and whether inflammation interacts with CAPD to increase LV diastolic dysfunction risks. Methods and results 120 subjects with normal creatinine levels and 101 CAPD patients were recruited. Echocardiographic parameters were assessed in all patients. The participants were classified as having LV diastolic dysfunction by echocardiographic findings including mitral inflow E / A ratio < 1, deceleration time > 220 cm/s, or decreased peak annular early diastolic velocity in tissue Doppler imaging. Blood was sampled at the baseline for measurement of inflammation markers, including tissue necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6). Subjects with LV diastolic dysfunction had higher proinflammation cytokines levels in both groups. Inflamed markers correlated significantly with echocardiography parameters for LV diastolic dysfunction in patients receiving CAPD. In a multivariate regression analysis adjusting for all the factors associated with LV diastolic dysfunction, inflammation is still significantly associated with left ventricular diastolic dysfunction (TNF-alpha, OR: 2.6, 95% CI: 2.0–3.35, p < 0.001; IL-6, OR: 1.26, 95% CI: 1.25–1.26, p = 0.01). In addition, the interaction of CAPD and inflammation significantly contributed to the development of LV diastolic dysfunction (CAPD∗ TNF-α: OR: 1.45, 95% CI: 1.13–1.79, P = 0.004). Conclusion We found inflammation plays a vital role for LV diastolic dysfunction especially in CAPD patients. A synergistic effect between CAPD and inflammation, especially TNF-α, would further aggravate LV diastolic dysfunction.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biomarkers - blood</subject><subject>blood</subject><subject>Cardiovascular</subject><subject>Case-Control Studies</subject><subject>Continuous ambulatory peritoneal dialysis</subject><subject>creatinine</subject><subject>Creatinine - blood</subject><subject>dialysis</subject><subject>echocardiography</subject><subject>Echocardiography, Doppler - methods</subject><subject>Female</subject><subject>Humans</subject><subject>image analysis</subject><subject>Inflammation</subject><subject>Inflammation - complications</subject><subject>Inflammation - physiopathology</subject><subject>interleukin-6</subject><subject>Interleukin-6 - blood</subject><subject>Left ventricular diastolic dysfunction</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>patients</subject><subject>Peritoneal Dialysis, Continuous Ambulatory</subject><subject>regression analysis</subject><subject>risk</subject><subject>Risk Factors</subject><subject>synergism</subject><subject>tumor necrosis factor-alpha</subject><subject>Tumor Necrosis Factor-alpha - blood</subject><subject>Ventricular Dysfunction, Left - complications</subject><subject>Ventricular Dysfunction, Left - physiopathology</subject><issn>0939-4753</issn><issn>1590-3729</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUsuO1DAQjBCIHRb-AIGPXDK043gyuSCh5SmtxGHZs-U4behZxx5sZ1H-iM_E84ADF6SWbEtV1eWurqrnHNYc-Ob1bu3nCc24boDzNZQC_qBacdlDLbqmf1itoBd93XZSXFRPUtoBiA5E-7i6aAqq6aRcVb_ekbUY0WfSjumUgiGdKXgWLNvHQN46PU06h7gws-RwRx4T-0n5O3NoM7sv1EhmdjqykXTKwZFh45Ls7M1RiDxL87BDk8887cfjJcyZmVA6-znMielpKCrHRnuMlIPHYqlouiVRelo9stolfHY-L6vbD--_Xn2qr798_Hz19ro27bbL9UYOuh9HoRsJhrdGbvoBcduB2YrWajlYaY3oy2MUPQjoGmEHLbTsZSOEEeKyenXSLZ__MWPKaqJk0DntsbhUnIt-0zRd3xVoe4KaGFKKaNU-0qTjojioQ0Zqp04ZqUNGCkoBL7QX5w7zMOH4l_QnlAJ4eQJYHZT-Fimp25uiIAFgy0ucBfHmhMAyiXvCqJIh9AZHimXOagz0Pw__ChhHnox2d7hg2oU5-jJlxVVqFKibwyYdFonz4gHkRvwGI23IoQ</recordid><startdate>20121101</startdate><enddate>20121101</enddate><creator>Lee, J.-K</creator><creator>Lin, H.-H</creator><creator>Tsai, C.-T</creator><creator>Chen, J.-J</creator><creator>Kuo, C.-C</creator><creator>Lien, Y.-C</creator><creator>Lin, J.-W</creator><creator>Huang, J.-W</creator><creator>Hwang, S.-W</creator><creator>Hwang, J.-J</creator><creator>Tseng, C.-D</creator><creator>Chiang, F.-T</creator><creator>Wu, C.-K</creator><general>Elsevier B.V</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20121101</creationdate><title>Differential association of proinflammatory cytokines with left ventricular diastolic dysfunction in subjects with and without continuous ambulatory peritoneal dialysis</title><author>Lee, J.-K ; Lin, H.-H ; Tsai, C.-T ; Chen, J.-J ; Kuo, C.-C ; Lien, Y.-C ; Lin, J.-W ; Huang, J.-W ; Hwang, S.-W ; Hwang, J.-J ; Tseng, C.-D ; Chiang, F.-T ; Wu, C.-K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c487t-65ba9dd3a250c14c569bee870c834fa5bf5fc39834d39030723fba3a595233c33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biomarkers - blood</topic><topic>blood</topic><topic>Cardiovascular</topic><topic>Case-Control Studies</topic><topic>Continuous ambulatory peritoneal dialysis</topic><topic>creatinine</topic><topic>Creatinine - blood</topic><topic>dialysis</topic><topic>echocardiography</topic><topic>Echocardiography, Doppler - methods</topic><topic>Female</topic><topic>Humans</topic><topic>image analysis</topic><topic>Inflammation</topic><topic>Inflammation - complications</topic><topic>Inflammation - physiopathology</topic><topic>interleukin-6</topic><topic>Interleukin-6 - blood</topic><topic>Left ventricular diastolic dysfunction</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>patients</topic><topic>Peritoneal Dialysis, Continuous Ambulatory</topic><topic>regression analysis</topic><topic>risk</topic><topic>Risk Factors</topic><topic>synergism</topic><topic>tumor necrosis factor-alpha</topic><topic>Tumor Necrosis Factor-alpha - blood</topic><topic>Ventricular Dysfunction, Left - complications</topic><topic>Ventricular Dysfunction, Left - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, J.-K</creatorcontrib><creatorcontrib>Lin, H.-H</creatorcontrib><creatorcontrib>Tsai, C.-T</creatorcontrib><creatorcontrib>Chen, J.-J</creatorcontrib><creatorcontrib>Kuo, C.-C</creatorcontrib><creatorcontrib>Lien, Y.-C</creatorcontrib><creatorcontrib>Lin, J.-W</creatorcontrib><creatorcontrib>Huang, J.-W</creatorcontrib><creatorcontrib>Hwang, S.-W</creatorcontrib><creatorcontrib>Hwang, J.-J</creatorcontrib><creatorcontrib>Tseng, C.-D</creatorcontrib><creatorcontrib>Chiang, F.-T</creatorcontrib><creatorcontrib>Wu, C.-K</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nutrition, metabolism, and cardiovascular diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, J.-K</au><au>Lin, H.-H</au><au>Tsai, C.-T</au><au>Chen, J.-J</au><au>Kuo, C.-C</au><au>Lien, Y.-C</au><au>Lin, J.-W</au><au>Huang, J.-W</au><au>Hwang, S.-W</au><au>Hwang, J.-J</au><au>Tseng, C.-D</au><au>Chiang, F.-T</au><au>Wu, C.-K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Differential association of proinflammatory cytokines with left ventricular diastolic dysfunction in subjects with and without continuous ambulatory peritoneal dialysis</atitle><jtitle>Nutrition, metabolism, and cardiovascular diseases</jtitle><addtitle>Nutr Metab Cardiovasc Dis</addtitle><date>2012-11-01</date><risdate>2012</risdate><volume>22</volume><issue>11</issue><spage>974</spage><epage>980</epage><pages>974-980</pages><issn>0939-4753</issn><eissn>1590-3729</eissn><abstract>Abstract Background and aims The association between inflammation and left ventricular (LV) diastolic dysfunction in continuous ambulatory peritoneal dialysis (CAPD) and non-CAPD patients is not established. The objective of this study was to test the above association and whether inflammation interacts with CAPD to increase LV diastolic dysfunction risks. Methods and results 120 subjects with normal creatinine levels and 101 CAPD patients were recruited. Echocardiographic parameters were assessed in all patients. The participants were classified as having LV diastolic dysfunction by echocardiographic findings including mitral inflow E / A ratio < 1, deceleration time > 220 cm/s, or decreased peak annular early diastolic velocity in tissue Doppler imaging. Blood was sampled at the baseline for measurement of inflammation markers, including tissue necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6). Subjects with LV diastolic dysfunction had higher proinflammation cytokines levels in both groups. Inflamed markers correlated significantly with echocardiography parameters for LV diastolic dysfunction in patients receiving CAPD. In a multivariate regression analysis adjusting for all the factors associated with LV diastolic dysfunction, inflammation is still significantly associated with left ventricular diastolic dysfunction (TNF-alpha, OR: 2.6, 95% CI: 2.0–3.35, p < 0.001; IL-6, OR: 1.26, 95% CI: 1.25–1.26, p = 0.01). In addition, the interaction of CAPD and inflammation significantly contributed to the development of LV diastolic dysfunction (CAPD∗ TNF-α: OR: 1.45, 95% CI: 1.13–1.79, P = 0.004). Conclusion We found inflammation plays a vital role for LV diastolic dysfunction especially in CAPD patients. A synergistic effect between CAPD and inflammation, especially TNF-α, would further aggravate LV diastolic dysfunction.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>21592755</pmid><doi>10.1016/j.numecd.2011.01.001</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Aged, 80 and over Biomarkers - blood blood Cardiovascular Case-Control Studies Continuous ambulatory peritoneal dialysis creatinine Creatinine - blood dialysis echocardiography Echocardiography, Doppler - methods Female Humans image analysis Inflammation Inflammation - complications Inflammation - physiopathology interleukin-6 Interleukin-6 - blood Left ventricular diastolic dysfunction Logistic Models Male Middle Aged Multivariate Analysis patients Peritoneal Dialysis, Continuous Ambulatory regression analysis risk Risk Factors synergism tumor necrosis factor-alpha Tumor Necrosis Factor-alpha - blood Ventricular Dysfunction, Left - complications Ventricular Dysfunction, Left - physiopathology |
| title | Differential association of proinflammatory cytokines with left ventricular diastolic dysfunction in subjects with and without continuous ambulatory peritoneal dialysis |
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