Guanine Nucleobase Adducts Formed by [Pt(di-(2-picolyl)amine)Cl]Cl: Evidence That a Tridentate Ligand with Only in-Plane Bulk Can Slow Guanine Base Rotation

Pt(II) complexes bind preferentially at N7 of G residues of DNA, causing DNA structural distortions associated with anticancer activity. Some distortions induced by difunctional cisplatin are also found for monofunctional Pt(II) complexes with carrier ligands having bulk projecting toward the guanin...

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Veröffentlicht in:	Inorganic chemistry 2012-11, Vol.51 (21), p.11961-11970
Hauptverfasser:	Andrepont, Chase, Marzilli, Patricia A, Marzilli, Luigi G
Format:	Artikel
Sprache:	eng
Schlagworte:	Amines - chemistry Amines - pharmacology Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology DNA Adducts - chemistry Guanine - chemistry Guanosine Monophosphate - chemistry Ligands Magnetic Resonance Spectroscopy Models, Molecular Organoplatinum Compounds - chemistry Organoplatinum Compounds - pharmacology Picolinic Acids - chemistry Picolinic Acids - pharmacology
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