Dopamine release via the vacuolar ATPase V0 sector c-subunit, confirmed in N18 neuroblastoma cells, results in behavioral recovery in hemiparkinsonian mice

A 16-kDa proteolipid, mediatophore, in Torpedo electric organs mediates Ca2+-dependent acetylcholine release. Mediatophore is identical to the pore-forming stalk c-subunit of the V0 sector of vacuolar proton ATPase (ATP6V0C). The function of ATP6V0C in the mammalian central nervous system is not cle...

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Veröffentlicht in:	Neurochemistry international 2012-11, Vol.61 (6), p.907-912
Hauptverfasser:	Jin, Duo, Muramatsu, Shin-ichi, Shimizu, Nobuaki, Yokoyama, Shigeru, Hirai, Hirokazu, Yamada, Kiyofumi, Liu, Hong-Xiang, Higashida, Chiharu, Hashii, Minako, Higashida, Akihiko, Asano, Masahide, Ohkuma, Shoji, Higashida, Haruhiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals ATPase Behavior, Animal Biological and medical sciences Cell Line, Tumor Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Dopamine Dopamine - metabolism Gene therapy Male Mediatophore Medical sciences Mice Mice, Inbred ICR Microdialysis Nervous system (semeiology, syndromes) Nervous system as a whole Neuroblastoma - enzymology Neuroblastoma - metabolism Neuroblastoma - pathology Neurology Parkinson disease Parkinson Disease - physiopathology Vacuolar Proton-Translocating ATPases - metabolism
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