Deficient Candida-Specific T-Helper 17 Response During Sepsis

Patients with sepsis in the intensive care unit (ICU) are prone to develop Candida infections. Here, we investigated Candida-induced T-helper 17 (Th17)responses during experimental human endotoxemia and in patients with sepsis admitted to the ICU. Peripheral blood mononuclear cells were stimulated w...

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Veröffentlicht in:	The Journal of infectious diseases 2012-12, Vol.206 (11), p.1798-1802
Hauptverfasser:	van de Veerdonk, Frank L., Mouktaroudi, Maria, Ramakers, Bart P., Pistiki, Aikaterini, Pickkers, Peter, van der Meer, Jos W. M., Netea, Mihai G., Giamarellos-Bourboulis, Evangelos J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacterial Infections - metabolism Biological and medical sciences Blood Candida albicans Candidiasis - metabolism Cytokines - genetics Cytokines - metabolism Endotoxemia Endotoxemia - microbiology Fundamental and applied biological sciences. Psychology FUNGI Gene Expression Regulation - physiology Health care administration Humans Infections Infectious diseases Inflammation - metabolism Intensive care units Interleukins Leukocytes, Mononuclear Medical sciences Microbiology Miscellaneous Mycology Peripheral blood mononuclear cells Predisposing factors Risk Factors Sepsis Sepsis - metabolism Sepsis - microbiology Th17 Cells - physiology
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