Maple polyphenols, ginnalins A–C, induce S- and G2/M-cell cycle arrest in colon and breast cancer cells mediated by decreasing cyclins A and D1 levels

► Ginnalins-A–C are polyphenols present in maple plant species. ► Ginnalins inhibited growth of human cancer but not non-tumorigenic cells. ► Ginnalins did not induce apoptosis of cancer cells but arrested cell cycle. ► Ginnalins decreased cyclins-A and D1 protein levels of cancer cells. Polyphenols...

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Veröffentlicht in:	Food chemistry 2013-01, Vol.136 (2), p.636-642
Hauptverfasser:	González-Sarrías, Antonio, Ma, Hang, Edmonds, Maxwell E., Seeram, Navindra P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acer - chemistry Acer saccharum subsp. saccharum Antiproliferative Apoptosis Biological and medical sciences Breast Neoplasms - drug therapy Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - physiopathology Cancer cell cycle Cell Cycle Checkpoints - drug effects Cell Line, Tumor colon Colonic Neoplasms - drug therapy Colonic Neoplasms - genetics Colonic Neoplasms - metabolism Colonic Neoplasms - physiopathology colorectal neoplasms Cyclin A - genetics Cyclin A - metabolism Cyclin D - genetics Cyclin D - metabolism cyclins D1 protein Deoxyglucose - analogs & derivatives Deoxyglucose - pharmacology Female Food industries food plants Fundamental and applied biological sciences. Psychology Gallic Acid - analogs & derivatives Gallic Acid - pharmacology Gene Expression Regulation, Neoplastic - drug effects Ginnalins Humans Male Maple maple syrup Plant Extracts - pharmacology Polyphenols Polyphenols - pharmacology sap Sorbitol - analogs & derivatives Sorbitol - pharmacology
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