PET-CT accurately predicts the pre-operative characteristics of colorectal hepatic metastases
Abstract Background Since 2002, Positron Emission Tomography (PET-CT) has been considered to be an essential pre-operative investigation in the management of colorectal liver metastases (CRLM) in our institution. This study aimed to compare characteristics of hepatic metastases on PET-CT with post-o...
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| Veröffentlicht in: | European journal of surgical oncology 2012-12, Vol.38 (12), p.1184-1188 |
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| creator | Jones, C Badger, S.A McKie, L.D Diamond, T Taylor, M.A Lynch, T.B |
| description | Abstract Background Since 2002, Positron Emission Tomography (PET-CT) has been considered to be an essential pre-operative investigation in the management of colorectal liver metastases (CRLM) in our institution. This study aimed to compare characteristics of hepatic metastases on PET-CT with post-operative histological findings and pathology of the primary tumour. Methods All patients with CRLM, who underwent surgical intervention from 2002 to 2008, were reviewed. PET-CT and pathology reports of hepatic resections and original colorectal resections were retrieved. Patient demographics, colorectal staging, number of metastases and their maximum diameter from both PET-CT and pathology reports were recorded. Values were expressed as mean (±SD). Results 141 patients were identified. The maximum diameter on PET-CT (4.2 ± 2.6) was similar to pathology (4.8 ± 3.6; p = 0.39), with significant correlation ( r = 0.72, p |
| doi_str_mv | 10.1016/j.ejso.2012.07.001 |
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This study aimed to compare characteristics of hepatic metastases on PET-CT with post-operative histological findings and pathology of the primary tumour. Methods All patients with CRLM, who underwent surgical intervention from 2002 to 2008, were reviewed. PET-CT and pathology reports of hepatic resections and original colorectal resections were retrieved. Patient demographics, colorectal staging, number of metastases and their maximum diameter from both PET-CT and pathology reports were recorded. Values were expressed as mean (±SD). Results 141 patients were identified. The maximum diameter on PET-CT (4.2 ± 2.6) was similar to pathology (4.8 ± 3.6; p = 0.39), with significant correlation ( r = 0.72, p < 0.0001). The number of lesions on PET-CT (1.6 ± 1.0) was similar to pathology (1.7 ± 1.3; p = 0.43) with significant correlation ( r = 0.80, p < 0.0001). Mean SUV max was 9.22 (±4.39), with no correlation to lesion diameter ( r = 0.25, p = 0.045), but significantly increased with decreasing differentiation ( p = 0.01). Conclusions PET-CT scanning accurately detected the number of lesions and their maximum diameter, with radiological evidence of poorer differentiation. Further studies of non-surgical patients are required to assess its overall accuracy.</description><identifier>ISSN: 0748-7983</identifier><identifier>EISSN: 1532-2157</identifier><identifier>DOI: 10.1016/j.ejso.2012.07.001</identifier><identifier>PMID: 22883963</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Colectomy ; Colorectal liver metastases ; Colorectal Neoplasms - diagnostic imaging ; Colorectal Neoplasms - pathology ; Colorectal Neoplasms - surgery ; Female ; Fluorodeoxyglucose F18 ; Follow-Up Studies ; Hematology, Oncology and Palliative Medicine ; Hepatectomy ; Humans ; Liver Neoplasms - diagnostic imaging ; Liver Neoplasms - secondary ; Liver Neoplasms - surgery ; Male ; Middle Aged ; Neoplasm Staging - methods ; PET-CT ; Positron-Emission Tomography - methods ; Predictive Value of Tests ; Preoperative Period ; Radiopharmaceuticals ; Reproducibility of Results ; Retrospective Studies ; Surgery</subject><ispartof>European journal of surgical oncology, 2012-12, Vol.38 (12), p.1184-1188</ispartof><rights>Elsevier Ltd</rights><rights>2012 Elsevier Ltd</rights><rights>Copyright © 2012 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c411t-71d32821db0739676c845ae05e7c397604ed494a2507d41ac6e6cac078dcc7623</citedby><cites>FETCH-LOGICAL-c411t-71d32821db0739676c845ae05e7c397604ed494a2507d41ac6e6cac078dcc7623</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0748798312009213$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22883963$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jones, C</creatorcontrib><creatorcontrib>Badger, S.A</creatorcontrib><creatorcontrib>McKie, L.D</creatorcontrib><creatorcontrib>Diamond, T</creatorcontrib><creatorcontrib>Taylor, M.A</creatorcontrib><creatorcontrib>Lynch, T.B</creatorcontrib><title>PET-CT accurately predicts the pre-operative characteristics of colorectal hepatic metastases</title><title>European journal of surgical oncology</title><addtitle>Eur J Surg Oncol</addtitle><description>Abstract Background Since 2002, Positron Emission Tomography (PET-CT) has been considered to be an essential pre-operative investigation in the management of colorectal liver metastases (CRLM) in our institution. This study aimed to compare characteristics of hepatic metastases on PET-CT with post-operative histological findings and pathology of the primary tumour. Methods All patients with CRLM, who underwent surgical intervention from 2002 to 2008, were reviewed. PET-CT and pathology reports of hepatic resections and original colorectal resections were retrieved. Patient demographics, colorectal staging, number of metastases and their maximum diameter from both PET-CT and pathology reports were recorded. Values were expressed as mean (±SD). Results 141 patients were identified. The maximum diameter on PET-CT (4.2 ± 2.6) was similar to pathology (4.8 ± 3.6; p = 0.39), with significant correlation ( r = 0.72, p < 0.0001). The number of lesions on PET-CT (1.6 ± 1.0) was similar to pathology (1.7 ± 1.3; p = 0.43) with significant correlation ( r = 0.80, p < 0.0001). Mean SUV max was 9.22 (±4.39), with no correlation to lesion diameter ( r = 0.25, p = 0.045), but significantly increased with decreasing differentiation ( p = 0.01). Conclusions PET-CT scanning accurately detected the number of lesions and their maximum diameter, with radiological evidence of poorer differentiation. Further studies of non-surgical patients are required to assess its overall accuracy.</description><subject>Colectomy</subject><subject>Colorectal liver metastases</subject><subject>Colorectal Neoplasms - diagnostic imaging</subject><subject>Colorectal Neoplasms - pathology</subject><subject>Colorectal Neoplasms - surgery</subject><subject>Female</subject><subject>Fluorodeoxyglucose F18</subject><subject>Follow-Up Studies</subject><subject>Hematology, Oncology and Palliative Medicine</subject><subject>Hepatectomy</subject><subject>Humans</subject><subject>Liver Neoplasms - diagnostic imaging</subject><subject>Liver Neoplasms - secondary</subject><subject>Liver Neoplasms - surgery</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neoplasm Staging - methods</subject><subject>PET-CT</subject><subject>Positron-Emission Tomography - methods</subject><subject>Predictive Value of Tests</subject><subject>Preoperative Period</subject><subject>Radiopharmaceuticals</subject><subject>Reproducibility of Results</subject><subject>Retrospective Studies</subject><subject>Surgery</subject><issn>0748-7983</issn><issn>1532-2157</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kV-L1DAUxYMo7rj6BXyQPvrSem_SNi2IIMP6BxYUHB8lZG_vMKmdSU3Shfn2pszqgw9C4BLuOYfkd4R4iVAhYPtmrHiMvpKAsgJdAeAjscFGyVJiox-LDei6K3XfqSvxLMYRAHql-6fiSsquU32rNuLH15tdud0VlmgJNvF0LubAg6MUi3Tg9VL6mfPK3XNBBxssJQ4uJkex8PuC_OQDU7JTceA5y6g4crIxH47PxZO9nSK_eJjX4vuHm932U3n75ePn7fvbkmrEVGoclOwkDneg87N0S13dWIaGNalet1DzUPe1lQ3ooUZLLbdkCXQ3EOlWqmvx-pI7B_9r4ZjM0UXiabIn9ks0iDkWOyUhS-VFSsHHGHhv5uCONpwNglmxmtGsWM2K1YA2GWs2vXrIX-6OPPy1_OGYBW8vAs6_vHccTCTHJ8okVzhm8O7_-e_-sdPkTo7s9JPPHEe_hFPmZ9DE7DHf1mLXXlHmSiUq9Rs8pp4p</recordid><startdate>20121201</startdate><enddate>20121201</enddate><creator>Jones, C</creator><creator>Badger, S.A</creator><creator>McKie, L.D</creator><creator>Diamond, T</creator><creator>Taylor, M.A</creator><creator>Lynch, T.B</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20121201</creationdate><title>PET-CT accurately predicts the pre-operative characteristics of colorectal hepatic metastases</title><author>Jones, C ; Badger, S.A ; McKie, L.D ; Diamond, T ; Taylor, M.A ; Lynch, T.B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c411t-71d32821db0739676c845ae05e7c397604ed494a2507d41ac6e6cac078dcc7623</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Colectomy</topic><topic>Colorectal liver metastases</topic><topic>Colorectal Neoplasms - diagnostic imaging</topic><topic>Colorectal Neoplasms - pathology</topic><topic>Colorectal Neoplasms - surgery</topic><topic>Female</topic><topic>Fluorodeoxyglucose F18</topic><topic>Follow-Up Studies</topic><topic>Hematology, Oncology and Palliative Medicine</topic><topic>Hepatectomy</topic><topic>Humans</topic><topic>Liver Neoplasms - diagnostic imaging</topic><topic>Liver Neoplasms - secondary</topic><topic>Liver Neoplasms - surgery</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neoplasm Staging - methods</topic><topic>PET-CT</topic><topic>Positron-Emission Tomography - methods</topic><topic>Predictive Value of Tests</topic><topic>Preoperative Period</topic><topic>Radiopharmaceuticals</topic><topic>Reproducibility of Results</topic><topic>Retrospective Studies</topic><topic>Surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jones, C</creatorcontrib><creatorcontrib>Badger, S.A</creatorcontrib><creatorcontrib>McKie, L.D</creatorcontrib><creatorcontrib>Diamond, T</creatorcontrib><creatorcontrib>Taylor, M.A</creatorcontrib><creatorcontrib>Lynch, T.B</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of surgical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jones, C</au><au>Badger, S.A</au><au>McKie, L.D</au><au>Diamond, T</au><au>Taylor, M.A</au><au>Lynch, T.B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>PET-CT accurately predicts the pre-operative characteristics of colorectal hepatic metastases</atitle><jtitle>European journal of surgical oncology</jtitle><addtitle>Eur J Surg Oncol</addtitle><date>2012-12-01</date><risdate>2012</risdate><volume>38</volume><issue>12</issue><spage>1184</spage><epage>1188</epage><pages>1184-1188</pages><issn>0748-7983</issn><eissn>1532-2157</eissn><abstract>Abstract Background Since 2002, Positron Emission Tomography (PET-CT) has been considered to be an essential pre-operative investigation in the management of colorectal liver metastases (CRLM) in our institution. This study aimed to compare characteristics of hepatic metastases on PET-CT with post-operative histological findings and pathology of the primary tumour. Methods All patients with CRLM, who underwent surgical intervention from 2002 to 2008, were reviewed. PET-CT and pathology reports of hepatic resections and original colorectal resections were retrieved. Patient demographics, colorectal staging, number of metastases and their maximum diameter from both PET-CT and pathology reports were recorded. Values were expressed as mean (±SD). Results 141 patients were identified. The maximum diameter on PET-CT (4.2 ± 2.6) was similar to pathology (4.8 ± 3.6; p = 0.39), with significant correlation ( r = 0.72, p < 0.0001). The number of lesions on PET-CT (1.6 ± 1.0) was similar to pathology (1.7 ± 1.3; p = 0.43) with significant correlation ( r = 0.80, p < 0.0001). Mean SUV max was 9.22 (±4.39), with no correlation to lesion diameter ( r = 0.25, p = 0.045), but significantly increased with decreasing differentiation ( p = 0.01). Conclusions PET-CT scanning accurately detected the number of lesions and their maximum diameter, with radiological evidence of poorer differentiation. Further studies of non-surgical patients are required to assess its overall accuracy.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>22883963</pmid><doi>10.1016/j.ejso.2012.07.001</doi><tpages>5</tpages></addata></record> |
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| subjects | Colectomy Colorectal liver metastases Colorectal Neoplasms - diagnostic imaging Colorectal Neoplasms - pathology Colorectal Neoplasms - surgery Female Fluorodeoxyglucose F18 Follow-Up Studies Hematology, Oncology and Palliative Medicine Hepatectomy Humans Liver Neoplasms - diagnostic imaging Liver Neoplasms - secondary Liver Neoplasms - surgery Male Middle Aged Neoplasm Staging - methods PET-CT Positron-Emission Tomography - methods Predictive Value of Tests Preoperative Period Radiopharmaceuticals Reproducibility of Results Retrospective Studies Surgery |
| title | PET-CT accurately predicts the pre-operative characteristics of colorectal hepatic metastases |
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